Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention generally provides a system for warming an outdoor surface. The system includes a heat exchange unit to provide heated air for use across the surface to melt snow or ice or to warm, evaporate or distribute water. The heat exchange unit is used to recapture the heated air. The present invention also generally provides a method of warming an outdoor surface. The method comprises the steps of providing heated air across the surface to melt snow or ice or to warm, evaporate or distribute water, recapturing the heated air, and redistributing the heated air across the surface.

Abstract: An antenna reflector and an associated latch system are provided. The antenna reflector includes a plurality of reflector portions that are connected in a predetermined configuration to define a continuous surface, such as a parabolic surface. The latches connect the reflector portions. Each latch includes first and second latch members, which define reference surfaces that are structured to contact when the latch is closed. In particular, the reference surfaces are disposed at predetermined and dissimilar distances from connection features of the respective latch members. For example, the first and second reference surfaces of the respective latch members can be disposed at first and second distances from apertures through the respective latch members. The first distance can be greater than the second distance so that, when a fastener is disposed through both apertures, the reference surfaces are urged together and the reflector portions are connected in a predetermined configuration.

Abstract: An antenna reflector and an associated latch system are provided. The antenna reflector includes a plurality of reflector portions that are connected in a predetermined configuration to define a continuous surface, such as a parabolic surface. The latches connect the reflector portions. Each latch includes first and second latch members, which define reference surfaces that are structured to contact when the latch is closed. In particular, the reference surfaces are disposed at predetermined and dissimilar distances from connection features of the respective latch members. For example, the first and second reference surfaces of the respective latch members can be disposed at first and second distances from apertures through the respective latch members. The first distance can be greater than the second distance so that, when a fastener is disposed through both apertures, the reference surfaces are urged together and the reflector portions are connected in a predetermined configuration.

Abstract: Complimentary animal models for retinoblastoma which recapitulate conditions found in the eye of human retinoblastoma patients in an animal are provided. These models are generated by introducing an agent capable of giving rise to a retinoblastoma into the developing eye of an immunologically naive animal. In one model the agent comprises cells which are capable of giving rise to a retinoblastoma. In another model the agent comprises a vector capable of expressing an oncogene which, when expressed in a transfected cell, can give rise to a cell mass that mimics the early stages of retinoblastoma formation. These models can be used to study retinoblastoma and screen for, or characterize, inhibitory agents. These models may also be used to study the influence of genotype or engineered genes or gene deficiencies (knock-outs) on the development of retinoblastoma.