Abstract: A combination radial artery occluder and wrist splint used to simultaneously immobilize the wrist joint and prevent blood flow through a puncture wound or incision in the radial artery following an invasive medical procedure such as catheterization. The invention generally includes three components: a wrist splint that extends along the distal end of the patient's forearm and the back of the wrist and hand; an adjustable pressure strap attached to the splint that extends around the distal end of the forearm; and an adjustable securing strap attached to the splint that extends around the palm of the patient's hand. The pressure strap includes a pressure pad that is selectively positioned to occlude blood flow through only the radial artery while allowing blood flow through the ulnar artery. During use of the invention, the securing strap is tightened around the palm of the hand to help immobilize the wrist joint.