Patents by Inventor Michael E. Coleman

Michael E. Coleman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11369716
    Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: June 28, 2022
    Assignees: INGENERON, INC., Board of Regents, The University of Texas System
    Inventors: Andrew M Altman, Eckhard U. Alt, Michael E. Coleman
  • Publication number: 20190175787
    Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.
    Type: Application
    Filed: February 21, 2019
    Publication date: June 13, 2019
    Applicants: Board of Regents, The University of Texas System, Ingeneron, Inc.
    Inventors: Andrew M. Altman, Eckhard U. Alt, Michael E. Coleman
  • Patent number: 10238770
    Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: March 26, 2019
    Assignees: Ingeneron, Inc., Board of Regents, The university of Texas System
    Inventors: Andrew M Altman, Eckhard U. Alt, Michael E. Coleman
  • Publication number: 20170088623
    Abstract: This document provides prophylactic methods for reducing cancer metastasis by targeting LCN2, MMP9, and CX-CR4.
    Type: Application
    Filed: September 30, 2015
    Publication date: March 30, 2017
    Applicants: Ingeneron, Inc., Board of Regents, The University of Texas System
    Inventors: Eckhard U. Alt, Ralph B. Arlinghaus, Michael E. Coleman
  • Patent number: 9453200
    Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: September 27, 2016
    Assignee: INGENERON INCORPORATED
    Inventors: Ron Stubbers, Michael E. Coleman
  • Publication number: 20160272943
    Abstract: A closed system apparatus and method for isolation and recovery of desired cells from body tissue includes a first container for tissue dissociation by subjection to centrifugation over one or more cycles of rotational acceleration and deceleration, a particle filter to filter out non-dissociated tissue while passing desired cells to a second container for separating the desired cells from connective tissue, unwanted material, liquid, and dissociation-aiding reagent(s) by subjection of the second container to combined centrifugal and gravitational forces that also causes concentration and sedimentation of the cells into a pellet for removal through a valve in the bottom of the second container.
    Type: Application
    Filed: December 15, 2015
    Publication date: September 22, 2016
    Inventors: Greg Stone, Ron Stubbers, Michael E. Coleman, Eckhard Alt
  • Publication number: 20160051729
    Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.
    Type: Application
    Filed: November 2, 2015
    Publication date: February 25, 2016
    Applicants: Ingeneron, Inc., Board of Regents, The University of Texas System
    Inventors: Andrew M Altman, Eckhard U. Alt, Michael E. Coleman
  • Publication number: 20150314041
    Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.
    Type: Application
    Filed: February 10, 2015
    Publication date: November 5, 2015
    Applicant: InGeneron Incorporated
    Inventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
  • Patent number: 9173975
    Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: November 3, 2015
    Assignees: Ingeneron, Inc., Board of Regents, The University of Texas System
    Inventors: Andrew M. Altman, Eckhard U. Alt, Michael E. Coleman
  • Publication number: 20150307845
    Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.
    Type: Application
    Filed: February 10, 2015
    Publication date: October 29, 2015
    Applicant: InGeneron Incorporated
    Inventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
  • Publication number: 20150299643
    Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.
    Type: Application
    Filed: February 10, 2015
    Publication date: October 22, 2015
    Applicant: InGeneron Incorporated
    Inventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
  • Publication number: 20150093809
    Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.
    Type: Application
    Filed: September 27, 2013
    Publication date: April 2, 2015
    Applicant: InGeneron, Inc.
    Inventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
  • Publication number: 20150056691
    Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.
    Type: Application
    Filed: August 28, 2014
    Publication date: February 26, 2015
    Inventors: Ron Stubbers, Michael E. Coleman
  • Patent number: 8951513
    Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: February 10, 2015
    Assignee: Ingeneron Incorporated
    Inventors: Eckhard U. Alt, Michael E. Coleman, Ron Stubbers
  • Publication number: 20150037387
    Abstract: Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 5, 2015
    Applicants: Board of Regents of the University of Texas System, Ingeneron, Inc.
    Inventors: Michael E. Coleman, Eckhard U. Alt, Ron Stubbers
  • Patent number: 8865199
    Abstract: Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: October 21, 2014
    Assignees: Ingeneron, Inc., Board of Regents of the University of Texas System
    Inventors: Michael E. Coleman, Eckhard U. Alt, Ron Stubbers
  • Publication number: 20130115697
    Abstract: This document describes methods and an apparatus for recovery of cells from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.
    Type: Application
    Filed: November 3, 2011
    Publication date: May 9, 2013
    Inventors: Eckhard U. Alt, Michael E. Coleman, Ron Stubbers
  • Patent number: 8309342
    Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: November 13, 2012
    Assignee: InGeneron, Inc.
    Inventors: Ron Stubbers, Michael E. Coleman
  • Publication number: 20120219561
    Abstract: This document provides prophylactic methods for reducing cancer metastasis by targeting LCN2, MMP9, and CX-CR4.
    Type: Application
    Filed: August 2, 2010
    Publication date: August 30, 2012
    Applicants: Ingeneron, Inc., Board of Regents, The University of Texas System
    Inventors: Eckhard U. Alt, Ralph B. Arlinghaus, Michael E. Coleman
  • Publication number: 20120195863
    Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.
    Type: Application
    Filed: December 16, 2011
    Publication date: August 2, 2012
    Inventors: Eckhard U. Alt, Michael E. Coleman, Ron Stubbers