Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: A system and method for a procedure that can be performed on an appropriate subject. A procedure may be planned, at least in part, prior to performing the procedure. An image may illustrate at least a portion of the planned procedure for confirmation and/or alteration of the planned procedure prior to performing the procedure.

Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Abstract: Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

Abstract: In one aspect of the present disclosure, a wheel hub is provided that includes a wheel hub body having an inboard end and an outboard end. The wheel hub body has a wheel mounting portion, such as a flange, intermediate the inboard and outboard ends. The wheel hub body has a central opening, an interior surface extending about the central opening, and an exterior surface opposite the interior surface. The wheel hub includes a passageway having an interior port at the interior surface of the wheel hub body and an exterior port at the exterior surface of the wheel hub body. The interior port is outboard of the inboard end of the wheel hub body. The exterior port is intermediate the wheel mounting portion and the outboard end of the wheel hub body.

Abstract: A marker delivery device comprises a marker deployer cannula, a push rod, a biopsy site marker, and a ramped tip. The marker deployer cannula may have a marker exit in communication with an interior lumen of the cannula. The marker exit may comprise a distal end with a ramped surface. The biopsy site marker may be configured with a plurality of edges. The plurality of edges may be configured to engage at least a portion of the interior lumen of the cannula. The ramped tip may comprise a first ramped surface and a second ramped surface, the second ramped surface may align with the ramped surface of the distal end of the marker exit. The push rod may be used to push the biopsy site marker up the ramped tip and through the marker exit.

Abstract: An electrochemical cell or battery uses iron gall ink as an electrolyte. In some examples, mold, bacteria, or yeast are allowed to grow on the electrolyte. The ink is made by combining tannic or gallic acid from a material such as dehydrated tea with a metal or transition metal sulfate, such as iron sulfate, potassium sulfate, or manganese sulfate. Urea, a metal or transition metal salt, and glycerin can also be added to the electrolyte to assist in the ion-producing reaction. One example includes electrodes made from iron and graphite, and an electrolyte of iron-gall or iron-tannate ink. Another example uses a manganese based ink. Aluminum, potassium, or sodium tannate ink, urea, and graphite can be used to make a metal-air cell, in which the cell is open to the air. The ink can be used as a charge transport in a redox-flow electrochemical cell. Yet another example utilizes Bauxite residue, a waste product of aluminum manufacture.

Abstract: The present disclosure provides FabI inhibitors and methods of treating or preventing a disease or disorder in a subject by administering same.

Abstract: Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.

Abstract: Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.

Abstract: An electronic transmission system and method for converting and transmitting transmissions to provide secure communication between a plurality of users and protect or secure content of each transmission by preventing unauthorized individuals from capturing and viewing or hearing the transmitted content in its entirety. The electronic transmission system breaks a transmission apart into a random plurality of pieces and randomly transmits each piece separately to a plurality of remote servers. If an unauthorized party tries to intercept and access an electronic transmission, they will not be able to capture the entire transmission and will not be able to recompile its actual content, but rather misleading content. A password or other suitable authentication requirement(s) authenticates the intended recipient and allows the original pieces to be retrieved and re-compiled for viewing or hearing.

Abstract: A system to create independent, local, online news services is described. User created content is aggregated to create local news services based on geographical segments and independent content contributors. Content is gathered from independent members and then segmented into web pages. Web pages utilize databases to segment the news content based on population by physical location. The content is then further segmented into categories and areas of interest. Individuals, who want to contribute content, are required to become members of a multi-level marketing network. The multi-level marketing network of members monitors an individual member's content that they provide to the news service. A rating system enables members and consumers to evaluate the content. Members are compensated on revenue that they and the members in their multi-level marketing group produce by marketing advertising and business services.

Abstract: Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.

Abstract: An electronic transmission system and method for converting and transmitting transmissions to provide secure communication between a plurality of users and protect or secure content of each transmission by preventing unauthorized individuals from capturing and viewing or hearing the transmitted content in its entirety. The electronic transmission system breaks a transmission apart into a random plurality of pieces and randomly transmits each piece separately to a plurality of remote servers. If an unauthorized party tries to intercept and access an electronic transmission, they will not be able to capture the entire transmission and will not be able to recompile its actual content, but rather misleading content. A password or other suitable authentication requirement(s) authenticates the intended recipient and allows the original pieces to be retrieved and re-compiled for viewing or hearing.

Abstract: A document encryption and decryption system and method for selectively encrypting and decrypting files and attachments, electronic mail, text messages, and any other items to protect or secure its contents by helping to prevent unauthorized individuals from viewing data in human-perceivable or readable form. The encryption and decryption system includes remote authentication to verify user credentials stored on a remote database hosted by a web server. The encryption system further includes remote deletion to automatically delete at least encrypted items stored on the user's computer, handheld or portable device, smartphone, tablet, and any other computer of any kind when enabled and logged onto a network. The encryption and decryption system includes selectively decrypting items by retrieving a decryption key and decrypting the item, and/or typing a decryption key if the item cannot be decrypted with the key, and/or sending an invitation to a recipient using the web server.

Abstract: A document encryption and decryption system for selectively encrypting and decrypting files and any other items and method for same to protect or secure its contents by helping to prevent unauthorized individuals from viewing data in human-perceivable or readable form. The encryption system includes remote authentication to verify a user's credentials stored on a remote database hosted by a web server. The encryption system further includes remote delete to automatically delete encrypted items stored on the user's computer, handheld or portable device, smartphone, and any other computing device of any kind when it logs onto a network if the user's computer or computing device is reported lost, stolen, or otherwise compromised. Decryption keys allow selective decryption of encrypted items that are on the computer or computing device of any kind. A Windows Communication Foundation service helps with authenticating the users with the encryption key and login process stored and processed by the web server.

Abstract: A marker delivery device comprises a marker deployer cannula, a push rod, a biopsy site marker, and a ramped tip. The marker deployer cannula may have a marker exit in communication with an interior lumen of the cannula. The marker exit may comprise a distal end with a ramped surface. The biopsy site marker may be configured with a plurality of edges. The plurality of edges may be configured to engage at least a portion of the interior lumen of the cannula. The ramped tip may comprise a first ramped surface and a second ramped surface, the second ramped surface may align with the ramped surface of the distal end of the marker exit. The push rod may be used to push the biopsy site marker up the ramped tip and through the marker exit.

Abstract: A biopsy device includes a body portion, a tip, at least one blade, and a cutter. The cannula defines at least one lumen. The cannula has a transverse aperture configured to receive tissue. The tip is located at the distal end of the cannula, and may include at least two concave surfaces. The blade extends longitudinally from the tip. A second blade may also extend longitudinally from the tip. Blades may be axially staggered relative to the cannula. Blades may also have lengths that differ from one another. In addition, a blade may have a pointed distal end, or may have a curved distal edge. The configuration of the blade and tip may provide reduced force to penetrate tissue. The blade and tip may produce a cut length that is greater than or equal to the length of the outer perimeter of the cannula.

Abstract: A biopsy device includes a body portion, a tip, at least one blade, and a cutter. The cannula defines at least one lumen. The cannula has a transverse aperture configured to receive tissue. The tip is located at the distal end of the cannula, and may include at least two concave surfaces. The blade extends longitudinally from the tip. A second blade may also extend longitudinally from the tip. Blades may be axially staggered relative to the cannula. Blades may also have lengths that differ from one another. In addition, a blade may have a pointed distal end, or may have a curved distal edge. The configuration of the blade and tip may provide reduced force to penetrate tissue. The blade and tip may produce a cut length that is greater than or equal to the length of the outer perimeter of the cannula.

Abstract: A document encryption and decryption system for selectively encrypting and decrypting files and any other items and method for same to protect or secure its contents by helping to prevent unauthorized individuals from viewing data in human-perceivable or readable form. The encryption system includes remote authentication to verify a user's credentials stored on a remote database hosted by a web server. The encryption system further includes remote delete to automatically delete encrypted items stored on the user's computer, handheld or portable device, smartphone, and any other computing device of any kind when it logs onto a network if the user's computer or computing device is reported lost, stolen, or otherwise compromised. Decryption keys allow selective decryption of encrypted items that are on the computer or computing device of any kind. A Windows Communication Foundation service helps with authenticating the users with the encryption key and login process stored and processed by the web server.