Patents by Inventor Michael E. Kobierski

Michael E. Kobierski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF MAKING INCRETIN ANALOGS
    Publication number: 20220411461
    Abstract: Intermediate compounds are disclosed for making incretin analogs, or pharmaceutically acceptable salts thereof. In addition, methods are disclosed for making incretin analogs by coupling from two to four of the intermediate compounds herein via hybrid liquid solid phase synthesis or native chemical ligation.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 29, 2022
    Inventors: Michael Eugene Kopach, Yu Lu, Sergey Vladimirovich Tsukanov, Timothy Donald White, Ankur Jalan, Jinju James, Michael E. Kobierski
  • Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
    Patent number: 5426187
    Abstract: Processes for preparing 4-hydroxy-5-ethynylpyrrolo[2,3-d]pyrimidine intermediates and N-[4-(2-{4-hydroxypyrrolo[2,3-d]pyrimidin-3-yl}ethyl)benzoyl]-L-glutamic acid derivatives having antineoplastic activity are provided.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: June 20, 1995
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Michael E. Kobierski
  • Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
    Patent number: 5235053
    Abstract: 4-Hydroxypyrrolo[2,3-d]pyrimidines are regiospecifically halogenated at the C-5 position by silylation in the presence of an inert organic solvent and iodination, bromination or chlorination.
    Type: Grant
    Filed: June 22, 1992
    Date of Patent: August 10, 1993
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Michael E. Kobierski