Patents by Inventor Michael E. O'Donnell

Michael E. O'Donnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8014315
    Abstract: A method includes determining a priority of each of a plurality of frames, wherein the priority is a function of an initial value dependent on content of each said frame and one or more adjustment values independent of content of each said frame, and selecting the frame with the highest determined priority for transmission through the device prior to transmission of any other of the frames. A system includes a receiving port configured to receive frames and assign an initial priority to each frame, a queue configured to insert queue entries associated with received frames on the queue, each queue entry being inserted at a queue position based on the initial priority assigned to the queue entry, the queue further configured to reorder queue entries based on readjusted priorities of the queue entries; and a transmitter switch configured to transmit the frame having the highest priority before transmitting any other frame.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: September 6, 2011
    Assignee: MCDATA Corporation
    Inventors: W. Jeffrey Mitchem, Michael E. O'Donnell
  • Patent number: 7848253
    Abstract: A method includes determining a priority of each of a plurality of frames, wherein the priority is a function of an initial value dependent on content of each said frame and one or more adjustment values independent of content of each said frame, and selecting the frame with the highest determined priority for transmission through the device prior to transmission of any other of the frames. A system includes a receiving port configured to receive frames and assign an initial priority to each frame, a queue configured to insert queue entries associated with received frames on the queue, each queue entry being inserted at a queue position based on the initial priority assigned to the queue entry, the queue further configured to reorder queue entries based on readjusted priorities of the queue entries; and a transmitter switch configured to transmit the frame having the highest priority before transmitting any other frame.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: December 7, 2010
    Assignee: McData Corporation
    Inventors: W. Jeffrey Mitchem, Michael E. O'Donnell
  • Patent number: 7803596
    Abstract: A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the polypeptides corresponding to T.th. ?, ?, ?, ? and ? subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: September 28, 2010
    Assignee: The Rockefeller University
    Inventors: Olga Yurieva, John Kuriyan, Michael E. O'Donnell, David Jeruzalmi
  • Publication number: 20100135312
    Abstract: A method includes determining a priority of each of a plurality of frames, wherein the priority is a function of an initial value dependent on content of each said frame and one or more adjustment values independent of content of each said frame, and selecting the frame with the highest determined priority for transmission through the device prior to transmission of any other of the frames. A system includes a receiving port configured to receive frames and assign an initial priority to each frame, a queue configured to insert queue entries associated with received frames on the queue, each queue entry being inserted at a queue position based on the initial priority assigned to the queue entry, the queue further configured to reorder queue entries based on readjusted priorities of the queue entries; and a transmitter switch configured to transmit the frame having the highest priority before transmitting any other frame.
    Type: Application
    Filed: October 21, 2009
    Publication date: June 3, 2010
    Inventors: W. Jeffrey Mitchem, Michael E. O'Donnell
  • Publication number: 20100003720
    Abstract: A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the polypeptides corresponding to T.th. ?, ?, ?, ? and ? subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.
    Type: Application
    Filed: June 4, 2009
    Publication date: January 7, 2010
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Olga YURIEVA, John KURIYAN, Michael E. O'DONNELL, David JERUZALMI
  • Publication number: 20090240035
    Abstract: The present invention relates to alpha-large, alpha-small, delta, delta prime, tau, beta, SSB, DnaG, and DnaB encoding genes from Gram positive bacterium, preferably Streptococcus and Staphylococcus bacterium. The formation of functional polymerase as well as the use of such a polymerase in sequencing and amplification is also disclosed. The individual genes and proteins or polypeptides are useful in identification of compounds with antibiotic activity.
    Type: Application
    Filed: June 25, 2008
    Publication date: September 24, 2009
    Inventors: Michael E. O'Donnell, Irina Bruck, Dan Zhang, Richard Whipple
  • Patent number: 7557184
    Abstract: The duplex DNA of chromosomes is replicated in a multicomponent process. A helicase unwinds the DNA, a replicase synthesizes new DNA, and primase repeatedly synthesizes new primed starts on the lagging strand. The present invention is directed to the genes from Gram positive bacterium encoding these proteins, and their characterization.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: July 7, 2009
    Assignee: The Rockefeller University
    Inventors: Michael E. O'Donnell, Dan Zhang, Richard Whipple
  • Patent number: 7556958
    Abstract: A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the polypeptides corresponding to T.th. ?, ?, ?, ? and ? subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: July 7, 2009
    Assignee: The Rockefeller University
    Inventors: Olga Yurieva, John Kuriyan, Michael E. O'Donnell, David Jeruzalmi
  • Publication number: 20090004675
    Abstract: The present invention relates to a method of identifying a candidate compound for modulating bacterial growth. This the method involves providing a ? clamp peptide from a bacterial replicase, providing a second peptide that binds to at least one amino acid of SEQ ID NO:9 that is not designated X, wherein the second peptide does not exhibit polymerase activity, and providing a test compound. The ? clamp peptide and the second peptide are contacted with the test compound, and the level of binding between the ? clamp peptide and the second peptide in the presence of the test compound is determined. The level of binding between the ? clamp peptide and the second peptide in the presence of the test compound is then compared to a control that does not contain the test compound. A test compound that alters the level of binding between the ? clamp peptide and the second peptide compared to the control is a candidate compound for modulating bacterial growth.
    Type: Application
    Filed: November 3, 2005
    Publication date: January 1, 2009
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Michael E. O'Donnell, Roxana Georgescu
  • Patent number: 7432365
    Abstract: The present invention relates to beta protein-encoding genes from Gram positive bacterium. Expression systems and host cells containing these genes are also disclosed.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: October 7, 2008
    Inventors: Michael E. O'Donnell, Irina Bruck, Dan Zhang, Richard Whipple
  • Publication number: 20080225859
    Abstract: A method includes determining a priority of each of a plurality of frames, wherein the priority is a function of an initial value dependent on content of each said frame and one or more adjustment values independent of content of each said frame, and selecting the frame with the highest determined priority for transmission through the device prior to transmission of any other of the frames. A system includes a receiving port configured to receive frames and assign an initial priority to each frame, a queue configured to insert queue entries associated with received frames on the queue, each queue entry being inserted at a queue position based on the initial priority assigned to the queue entry, the queue further configured to reorder queue entries based on readjusted priorities of the queue entries; and a transmitter switch configured to transmit the frame having the highest priority before transmitting any other frame.
    Type: Application
    Filed: March 19, 2008
    Publication date: September 18, 2008
    Applicant: McData Corporation
    Inventors: W. Jeffrey Mitchem, Michael E. O'Donnell
  • Patent number: 7382736
    Abstract: A method for selective transmission of through a switch according to a quality of service level includes providing one or more switches in a fibre channel fabric, particularly one or more fibre channel switches. The method includes assigning an initial score to the content of the one or more frames of data. The initial score may be adjusted by one or more alternative score components to determine one or more adjusted scores. The adjusted scores are compared. The method also provides for selecting frames having the highest adjusted scores and transmitting through the switches the frames having the highest adjusted scores.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: June 3, 2008
    Assignee: McData Corporation
    Inventors: W. Jeffrey Mitchem, Michael E. O'Donnell
  • Patent number: 6897053
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: May 24, 2005
    Assignee: Rockefeller University
    Inventors: Michael E. O'Donnell, Olga Yurieva
  • Patent number: 6875852
    Abstract: The present invention is directed toward the 5 previously unknown genes, for subunits ?, ??, ?, ?, and ?, of the DNA polymerase III holoenzyme, and toward a unique man-made enzyme containing 5, preferably 6, protein subunits which shows the same activity as the naturally occurring 10 protein subunit DNA polymerase III holoenzyme.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: April 5, 2005
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Michael E. O'Donnell
  • Publication number: 20040197796
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: October 7, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Publication number: 20040110210
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: June 10, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Publication number: 20040106137
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polyrnerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: June 3, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Publication number: 20040081995
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 29, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Publication number: 20040077012
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 22, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Publication number: 20040048309
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: March 11, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan