Patents by Inventor Michael E. Rickey

Michael E. Rickey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Patent number: 7547452
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release over a period of from about 7 days to about 200 days. The microparticles may be formulated with a biodegradable and biocompatible polymer, and an active agent, such as risperidone, 9-hydroxy-risperidone, and pharmaceutically acceptable acid addition salts of the foregoing.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: June 16, 2009
    Assignees: Alkermes, Inc., Janssen Pharmaceutica, N.V
    Inventors: Thomas J. Atkins, Michael E. Rickey, Jean Mesens
  • Residual solvent extraction method and microparticles produced thereby
    Patent number: 7524530
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: April 28, 2009
    Assignee: Alkermes, Inc.
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Poly(lactide-Co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar
    Publication number: 20090035253
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: April 15, 2005
    Publication date: February 5, 2009
    Applicants: AMYLIN PHARMACEUTICALS, INC., ALKEMES CONTROLLED THERAPEUTICS,
    Inventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino, Christine M. Smith, David Lokensgard, Mark Fineman, John Ong
  • Polymer-based sustained release device
    Patent number: 7456254
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: November 25, 2008
    Assignee: Alkermes, Inc.
    Inventors: Steven G. Wright, Troy Christenson, Thean Y. Yeah, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
  • Polymer-Based Sustained Release Device
    Publication number: 20080260847
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: April 15, 2004
    Publication date: October 23, 2008
    Applicant: Alkermes, Inc.
    Inventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
  • Polymer-based sustained release device
    Publication number: 20080125348
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: July 16, 2007
    Publication date: May 29, 2008
    Applicant: Alkermes, Inc.
    Inventors: Steven G. Wright, Troy Christensen, Thean Y. Yeah, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
  • Polymer-based sustained release device
    Publication number: 20080125351
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: July 20, 2007
    Publication date: May 29, 2008
    Applicant: Alkermes, Inc.
    Inventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
  • Polymer-based sustained release device
    Publication number: 20080125349
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: July 16, 2007
    Publication date: May 29, 2008
    Applicant: Alkermes, Inc.
    Inventors: Steven G. Wright, Troy Christensen, Thean Yeah, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino
  • Polymer-based sustained release device
    Publication number: 20080119569
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: July 20, 2007
    Publication date: May 22, 2008
    Applicant: Alkermes, Inc.
    Inventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Mark Fineman, Christine Smith, John Ong, David M. Lokensgard, Henry R. Costantino
  • Residual solvent extraction method and microparticles produced thereby
    Patent number: 7223440
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: May 29, 2007
    Assignee: Alkermes, Inc.
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Patent number: 7118763
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: October 10, 2006
    Assignees: Alkermes Controlled Therapeutics, Inc. II, Janssen Pharmaceutica
    Inventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins
  • Residual solvent extraction method and microparticles produced thereby
    Patent number: 6824822
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: November 30, 2004
    Assignee: Alkermes Controlled Therapeutics Inc. II
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Patent number: 6803055
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: October 12, 2004
    Assignees: Alkermas Controlled Therapeutics Inc. II, Janssen Pharmaceutica
    Inventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins
  • Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
    Publication number: 20040197417
    Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is_ prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.
    Type: Application
    Filed: July 25, 2003
    Publication date: October 7, 2004
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Michael E. Rickey, J. Michael Ramstack, Danny H. Lewis
  • Method for preparing microparticles having a selected polymer molecular weight
    Publication number: 20030211164
    Abstract: A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.
    Type: Application
    Filed: June 5, 2003
    Publication date: November 13, 2003
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Steven G. Wright, Michael E. Rickey, J. Michael Ramstack, Shawn L. Lyons, Joyce M. Hotz
  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Publication number: 20030165571
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.
    Type: Application
    Filed: February 6, 2003
    Publication date: September 4, 2003
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins
  • Method for preparing microparticles having a selected polymer molecular weight
    Publication number: 20030143279
    Abstract: A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.
    Type: Application
    Filed: January 28, 2003
    Publication date: July 31, 2003
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Steven G. Wright, Michael E. Rickey, J. Michael Ramstack, Shawn L. Lyons, Joyce M. Hotz
  • Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
    Publication number: 20030129249
    Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.
    Type: Application
    Filed: October 23, 2002
    Publication date: July 10, 2003
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Michael E. Rickey, J. Michael Ramstack, Danny H. Lewis
  • Residual solvent extraction method and microparticles produced thereby
    Publication number: 20030118660
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Application
    Filed: August 31, 2001
    Publication date: June 26, 2003
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Patent number: 6544559
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: April 8, 2003
    Assignees: Alkermes Controlled Therapeutics Inc. II, Janssen Parmaceutica
    Inventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins