Patents by Inventor Michael E. Severino

Michael E. Severino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Niemann Pick C1-Like 1 Gene (NPC1L1) Polymorphisms and Methods of Use Thereof
    Publication number: 20090192135
    Abstract: The present invention relates to the identification and use of single nucleotide polymorphisms and haplotypes in the Niemann Pick C1-Like 1 (NPC1L1) gene. In particular, methods are provided for correlating NPC1L1 polymorphisms and haplo-types with the responsiveness of a pharmaceutically active compound administered to a human subject. The invention further relates to a method for estimating the responsiveness of a pharmaceutically active compound administered to a human subject which method comprises determining at least one polymorphism in the NPC1L1 gene. The methods are based on determining polymorphisms in the NPC1L1 gene and correlating the responsiveness of a pharmaceutically active compound in the human by reference to one or more polymorphism in NPC1L1.
    Type: Application
    Filed: March 28, 2006
    Publication date: July 30, 2009
    Applicants: SCHERING CORPORATION, MERCK & CO., INC., ROSETTA INPHARMATICS LLC
    Inventors: Jason Samuel Simon, Maha Chabhar Karnoub, Michael E. Severino, David James Devlin, Andrew Stewart Plump, Eric E. Schadt