Abstract: A system may receive hazard data including an indication of one or more events, for example based on one or more of current climate conditions or future climate conditions. The system may receive geographic data. The system may determine, for example based at least in part on the geographic data, a portfolio including a plurality of locations. The system may group each of the one or more events into one or more annual groups. The system may forecast, for example based at least in part on the hazard data and the geographic data, a geographic extent and/or a severity of the one or more events. The system may forecast, for example based at least in part on the hazard data and/or the geographic data, a likelihood that a hazard will occur within a time frame associated with a first annual group of the one or more annual groups.

Abstract: Compositions of polynucleotide(s), pharmaceutical compositions thereof, and methods of use thereof are disclosed. A polynucleotide may encode for a cystic fibrosis transmembrane conductance regulator (CFTR) protein or a functional fragment thereof. The polynucleotide may be assembled with a lipid composition for targeted delivery to a cell or an organ, such as a lung cell or a lung of a subject. Methods for enhancing an expression or activity of CFTR protein in a cell are provided. Methods for treating a subject having or suspected of having a CFTR-associated condition are also provided.