Abstract: The present invention provides for methods of differentiating induced pluripotent stem cells into pancreatic progenitor cells, pancreatic ductal cells, pancreatic endocrine cells, pancreatic acinar cells, and pancreatic organoids. Cells created by these methods are also provided. Further provided are disease models and methods of drug screening.

Abstract: Provided are materials and methods related to a roofing material comprising at least two layers of polymeric materials, a top layer exposed to the environment and a bottom layer contacting the roof structure, the top layer including an amount of metallic appearing special effect pigment material to impart a metallic appearance. The polymeric material may be a thermoplastic olefin resin, a polyvinyl chloride resin, or other material. Additionally, the polymeric materials contain UV stabilizers and/or flame retardants, smoke suppressants or other fillers.

Abstract: A method of conducting a due diligence procedure of a contemplated, continuing or follow-up business transaction between first and second parties generally consisting of devising a list of inquiries, assigning values to such inquiries, establishing levels of risk exposure due to each response to such inquiries, eliciting responses to such inquiries and the assignment of a level of risk exposure to each of such responses, and evaluating the relevant risk exposure in proceeding with such transaction by a consideration of the values assigned to such inquiries and the assigned levels of risk exposure to responses to such inquires.

Abstract: A management system for determining the security measures of a plurality of vendors. An assessment is performed on a plurality of vendors at a discount. The assessment is placed into a database and is reviewable and accessible by clients who subscribe to the management system. The management system allows clients to review and assess the security information regarding a plurality of vendors without the cost of performing an assessment of each vendor.

Abstract: A software package comprises an application broker export module exportable from a first device to a second device, the application broker export module including an instance opening sub-module for opening a first instance of an application broker for managing operation of applications exported from the first device to the second device and for opening a second instance of the application broker for managing operation of applications between the second device and a third device. A method of communicating comprises the steps of forwarding to a first device a first request from a second device, the first request including an application broker software package, initiating at the first device a first instance of an application broker from the application broker software package, wherein the first instance includes an object to process the first request and establishing a first connection between the first and second devices in response to the first request.