Abstract: A preferred system for ensuring the safety of a glovebox can include a glovebox configured for handling a sensitive material and comprising a pair of ports adjacent to a working cavity; a pair of gloves connected to the pair of ports and extending into the working cavity; and a plug removably connectable to one of the pair of ports. In preferred variations, the plug can include a protective material, a removable handle, and a shielding cavity. In alternative variations, the plug can also include a tamper indicating device to ensure that the plug, once engaged into the port, is not removed without proper authority or permission.