Patents by Inventor Michael Edward Kobierski

Michael Edward Kobierski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING A GLP-1/GLUCAGON DUAL AGONIST
    Publication number: 20230220000
    Abstract: The present invention provides processes and compounds for the preparation of glucagon and GLP-1 co-agonist compounds that are useful in the treatment of type 2 diabetes, obesity, nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH).
    Type: Application
    Filed: June 11, 2021
    Publication date: July 13, 2023
    Inventors: Michael Edward KOBIERSKI, Michael Eugene KOPACH
  • Process development of a pyridine-containing NK-1 receptor antagonist
    Patent number: 10287287
    Abstract: The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: May 14, 2019
    Assignee: ELI LILLY AND COMPANY
    Inventors: Michael E. Kopach, Thomas Michael Wilson, Michael Edward Kobierski
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF {1-(ETHYLSULFONYL)-3-[4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]AZETIDIN-3-YL}ACETONITRILE
    Publication number: 20190062337
    Abstract: The present invention provides processes and intermediates for the preparation of {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile: (I)
    Type: Application
    Filed: October 25, 2018
    Publication date: February 28, 2019
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Joseph R. Martinelli, David Lee Varie, Thomas Michael Wilson
  • PROCESS DEVELOPMENT OF A PYRIDINE-CONTAINING NK-1 RECEPTOR ANTAGONIST
    Publication number: 20180237433
    Abstract: The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 23, 2018
    Inventors: Michael E. Kopach, Thomas Michael Wilson, Michael Edward Kobierski
  • Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone
    Patent number: 10035787
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: July 31, 2018
    Assignee: ELI LILLY AND COMPANY
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF {1-(ETHYLSULFONYL)-3-[4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]AZETIDIN-3-YL}ACETONITRILE
    Publication number: 20180134713
    Abstract: The present invention provides processes and intermediates for the preparation of {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile: (I)
    Type: Application
    Filed: June 16, 2016
    Publication date: May 17, 2018
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Joseph R. Martinelli, David Lee Varie, Thomas Michael Wilson
  • NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE
    Publication number: 20170283394
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Application
    Filed: June 15, 2017
    Publication date: October 5, 2017
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl)-(2-chlorophenyl)-methanone
    Patent number: 9708291
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 18, 2017
    Assignee: Vanda Pharmaceuticals Inc.
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE
    Publication number: 20160060250
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Application
    Filed: November 10, 2015
    Publication date: March 3, 2016
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE
    Publication number: 20140206877
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 24, 2014
    Applicant: Eli Lilly and Company
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE
    Publication number: 20100056795
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: (I) The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV
    Type: Application
    Filed: December 4, 2007
    Publication date: March 4, 2010
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • Stereoselective process for preparing cylcohexyl amine derivatives
    Publication number: 20040010005
    Abstract: A process for preparing (1R,3S)-3-(9-chloro-3-methyl-4-oxo-5H-(isoxazoloquinolin-5-yl))cyclohexanecarboxylic acid and esters thereof, as represented by formulas II and III, wherein R is a lower alkyl groups, and A and B are N or O, provided that when A is N, B is O, or when A is O, B is N: Formula (III) and Formula (II).
    Type: Application
    Filed: February 21, 2003
    Publication date: January 15, 2004
    Inventors: Charles Jackson Barnett, Rui Lin Gu, Michael Edward Kobierski
  • Process for preparing a 10,11-methanodibenzosuberane derivative
    Patent number: 6624304
    Abstract: This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: September 23, 2003
    Assignee: Eli Lilly and Company
    Inventors: Bret Anthony Astleford, Charles Jackson Barnett, Michael Edward Kobierski, Thomas Michael Wilson
  • Process for preparing a 10,11-methanodibenzosuberane derivative
    Patent number: 6570016
    Abstract: This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: May 27, 2003
    Assignee: Eli Lilly and Company
    Inventors: Bret Anthony Astleford, Charles Jackson Barnett, Michael Edward Kobierski, Thomas Michael Wilson
  • Processes and intermediates useful to make antifolates
    Patent number: 6426417
    Abstract: The present invention concerns intermediates, and processes directed to and from those intermediates, to a series of pyrimidine derivatives of formula (V), which are intermediates to useful antifolate compounds or are themselves useful antifolate compounds.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: July 30, 2002
    Assignee: Eli Lilly and Company
    Inventors: Charles Jackson Barnett, Steven Eugene Dunlap, Michael Edward Kobierski, John Arnold Werner