Patents by Inventor Michael Elashoff

Michael Elashoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190354888
    Abstract: A system for predicting subject enrollment for a study includes a time-to-first-enrollment (TTFE) model and a first-enrollment-to-last-enrollment (FELE) model for each site in the study. The TTFE model includes a Gaussian distribution with a generalized linear mixed effects model solved with maximum likelihood point estimation or with Bayesian regression, and the FELE model includes a negative binomial distribution with a generalized linear mixed effects model solved with maximum likelihood point estimation or with Bayesian regression estimation.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 21, 2019
    Inventors: Hrishikesh Karvir, Fanyi Zhang, Jingshu Liu, Michael Elashoff, Christopher Bound
  • Publication number: 20190252043
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Inventors: Michael ELASHOFF, Hrishikesh KARVIR, Piraye Yurttas BEIM
  • Patent number: 10339267
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: July 2, 2019
    Assignee: CELMATIX, INC.
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Patent number: 10208350
    Abstract: Methods for assessing infertility and related pathologies and informing treatment type and timing thereof are provided. According to certain embodiments, methods of the invention include determining levels of one or more transcripts present in a sample obtained from a subject suspected of having endometriosis, identifying transcript levels that correspond to a regulation pattern specific to a time-point in a uterine cycle, and characterizing endometriosis of the subject based upon the identified transcript levels. The invention includes methods for assessing age-associated increase in aneuploidy rates based on FSH levels and IVF success rates based on obesity in PCOS patients.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: February 19, 2019
    Assignee: Celmatix Inc.
    Inventors: Piraye Yurttas Beim, David Emlyn Parfitt, Michael Elashoff
  • Patent number: 10162800
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: December 25, 2018
    Assignee: Celmatix Inc.
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Publication number: 20180246876
    Abstract: An apparatus for automatically mapping a verbatim narrative to a term in a medical terminology dictionary includes a natural language processor and a comparator. The natural language processor processes terms from the medical terminology dictionary and from a medical coding decision database to generate a processed database that also includes the original terms from the medical terminology dictionary and the medical coding decision database. The natural language processor also processes the verbatim narrative. The comparator compares the processed verbatim narrative to the terms in the processed database and determines whether the processed verbatim narrative is an exact match to a term in the processed database. The verbatim narrative is mapped to the term in the medical terminology dictionary that corresponds to the term in the processed database that is an exact match. The verbatim narratives may include adverse event narratives, concomitant medication narratives, or other types of narratives.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 30, 2018
    Inventors: Patricia Allen, Andrew Howland, Philip Beineke, Mark Chandler, Michael Elashoff, Mladen Laudanovic, Jingshu Liu, Michael Cestone, Jenny Liu
  • Publication number: 20180218117
    Abstract: The invention generally relates to methods and devices for assessing risk of female infertility. In certain aspects, methods of the invention involve obtaining a sample, conducting an assay on at least one infertility-associated biomarker, and assessing risk to the patient of developing early-onset decrease in fertility based upon results of the assay.
    Type: Application
    Filed: December 4, 2017
    Publication date: August 2, 2018
    Inventors: Piraye Yurttas Beim, Michael Elashoff
  • Publication number: 20170351844
    Abstract: A system for determining relative operational performance in a clinical trial may include a processor, a data comparator and visualizer, and a graphical user interface. The processor filters received clinical data into multiple metric criteria to generate multiple metric data sets and filters each metric data set into a respective industry data set and a respective candidate data set. The processor then calculates statistical measures for each industry data set and candidate data set and transforms each industry data set and candidate data set based on each data set's respective statistical measures. The data comparator and visualizer compares each transformed candidate data set to the transformed industry data set for the respective metric criterion to determine a candidate percentile for each metric criterion. The graphical user interface displays the candidate percentiles for the metric criteria. A method for determining relative operational performance in a clinical trial is also described.
    Type: Application
    Filed: April 26, 2017
    Publication date: December 7, 2017
    Inventors: David Lee, Michael Elashoff, Joshua Hartman, Richard Kwock, John Savage, Steven Schwager
  • Patent number: 9836577
    Abstract: The invention generally relates to methods and devices for assessing risk of female infertility. In certain aspects, methods of the invention involve obtaining a sample, conducting an assay on at least one infertility-associated biomarker, and assessing risk to the patient of developing early-onset decrease in fertility based upon results of the assay.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: December 5, 2017
    Assignee: Celmatix, Inc.
    Inventors: Piraye Yurttas Beim, Michael Elashoff
  • Publication number: 20160130656
    Abstract: The disclosure in some aspects provides methods of determining the likelihood that a subject has lung cancer based on the expression of informative-genes. In other aspects, the disclosure provides methods for determining an appropriate diagnostic intervention plan for a subject based on the expression of informative-genes. Related compositions and kits are provided in other aspects of the disclosure.
    Type: Application
    Filed: July 14, 2015
    Publication date: May 12, 2016
    Inventors: Duncan H. WHITNEY, Michael ELASHOFF
  • Publication number: 20160078172
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Application
    Filed: September 18, 2015
    Publication date: March 17, 2016
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Publication number: 20160017426
    Abstract: Methods for assessing infertility and related pathologies and informing treatment type and timing thereof are provided. According to certain embodiments, methods of the invention include determining levels of one or more transcripts present in a sample obtained from a subject suspected of having endometriosis, identifying transcript levels that correspond to a regulation pattern specific to a time-point in a uterine cycle, and characterizing endometriosis of the subject based upon the identified transcript levels. The invention includes methods for assessing age-associated increase in aneuploidy rates based on FSH levels and IVF success rates based on obesity in PCOS patients.
    Type: Application
    Filed: July 17, 2015
    Publication date: January 21, 2016
    Inventors: Piraye Yurttas Beim, David Emlyn Parfitt, Michael Elashoff
  • Patent number: 9177098
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: November 3, 2015
    Assignee: Celmatix Inc.
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Publication number: 20150220868
    Abstract: An analysis server obtains data associated with patients as part of a clinical trial. The analysis server derives models from the patient data, the models specifying how likely it is that a given value of a variable (or values of a pair of variables) are erroneous. The models can be applied to the patient data to identify variable values more likely to be erroneous, and in turn to assess the data quality of patients, sites, and the clinical trial itself.
    Type: Application
    Filed: January 30, 2015
    Publication date: August 6, 2015
    Inventor: Michael Elashoff
  • Publication number: 20150211068
    Abstract: The invention generally relates to methods for assessing whether a genetic region is associated with infertility.
    Type: Application
    Filed: January 26, 2015
    Publication date: July 30, 2015
    Inventors: Piraye Yurttas Beim, Michael Elashoff
  • Publication number: 20150142331
    Abstract: The invention generally relates to methods and devices for assessing risk of female infertility. In certain aspects, methods of the invention involve obtaining a sample, conducting an assay on at least one infertility-associated biomarker, and assessing risk to the patient of developing early-onset decrease in fertility based upon results of the assay.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventors: Piraye Yurttas Beim, Michael Elashoff
  • Publication number: 20140107934
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Application
    Filed: October 11, 2013
    Publication date: April 17, 2014
    Applicant: CELMATIX, INC.
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Publication number: 20140107991
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Application
    Filed: October 17, 2012
    Publication date: April 17, 2014
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Patent number: D787526
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: May 23, 2017
    Assignee: Medidata Solutions, Inc.
    Inventors: David Lee, Joshua Hartman, John Savage, Richard Kwock, Michael Elashoff, Pramod Somashaker
  • Patent number: D822688
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: July 10, 2018
    Assignee: Medidata Solutions, Inc.
    Inventors: David Lee, Joshua Hartman, John Savage, Richard Kwock, Michael Elashoff, Pramod Somashekar