Patents by Inventor Michael Elowitz

Michael Elowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Programmable protein circuits in living cells
    Patent number: 11965191
    Abstract: The present disclosure relates to systems, methods and compositions provided herein that include a compound protease. The compound protease can contain a protease domain, a cut site for another enzyme and an association domain. In some embodiments, the compound protease is part of a protein circuit.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: April 23, 2024
    Assignee: California Institute of Technology
    Inventors: Xiaojing Gao, Lucy S. Chong, Michael Elowitz, Mark William Budde, Matthew Sun-min Kim
  • Fractional regulation of transcription
    Patent number: 11674144
    Abstract: A method of controlling the number of cells in a population of cells having silenced transcription of a target nucleic acid as a function of time includes recruiting a chromatin regulator (CR) to a site proximal to a transcription initiation site of the target nucleic acid to form a fraction of silenced cells in the population of cells. The chromatin regulator may be EED, KRAB, DNMT3, HDAC4, EZH2, REST, or a combination thereof.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: June 13, 2023
    Assignee: California Institute of Technology
    Inventors: Michael Elowitz, Lacramioara Bintu, John Yong
  • Compositions and methods for programmable sensing and control through combinatorial molecular interactions
    Patent number: 11604198
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: March 14, 2023
    Assignee: California Institute of Technology
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz, Heidi Klumpe
  • PROGRAMMABLE PROTEIN CIRCUITS IN LIVING CELLS
    Publication number: 20210238570
    Abstract: Some embodiments of the systems, methods and compositions provided herein relate to a compound protease. In some embodiments, the compound protease includes a protease domain and a cut site for another enzyme. In some embodiments, the compound protease includes an association domain. In some embodiments, the compound protease is part of a protein circuit.
    Type: Application
    Filed: January 25, 2021
    Publication date: August 5, 2021
    Inventors: Xiaojing Gao, Lucy S. Chong, Michael Elowitz, Mark William Budde, Matthew Sun-min Kim
  • Programmable protein circuits in living cells
    Patent number: 10899823
    Abstract: Some embodiments of the systems, methods and compositions provided herein relate to a compound protease. In some embodiments, the compound protease includes a protease domain and a cut site for another enzyme. In some embodiments, the compound protease includes an association domain. In some embodiments, the compound protease is part of a protein circuit.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: January 26, 2021
    Assignee: California Institute of Technology
    Inventors: Xiaojing Gao, Lucy S. Chong, Michael Elowitz, Mark William Budde, Matthew Sun-min Kim
  • COMPOSITIONS AND METHODS FOR PROGRAMMABLE SENSING AND CONTROL THROUGH COMBINATORIAL MOLECULAR INTERACTIONS
    Publication number: 20200116717
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Application
    Filed: December 2, 2019
    Publication date: April 16, 2020
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz, Heidi Klumpe
  • Compositions and methods for programmable sensing and control through combinatorial molecular interactions
    Patent number: 10527631
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: January 7, 2020
    Assignee: California Institute of Technology
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz, Heidi Klumpe
  • PROGRAMMABLE PROTEIN CIRCUITS IN LIVING CELLS
    Publication number: 20190248873
    Abstract: Some embodiments of the systems, methods and compositions provided herein relate to a compound protease. In some embodiments, the compound protease includes a protease domain and a cut site for another enzyme. In some embodiments, the compound protease includes an association domain. In some embodiments, the compound protease is part of a protein circuit.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 15, 2019
    Inventors: Xiaojing Gao, Lucy S. Chong, Michael Elowitz, Mark William Budde, Matthew Sun-min Kim
  • Compositions and methods for programmable sensing and control through combinatorial molecular interactions
    Publication number: 20180172704
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 21, 2018
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz
  • FRACTIONAL REGULATION OF TRANSCRIPTION
    Publication number: 20160304872
    Abstract: A method of controlling the number of cells in a population of cells having silenced transcription of a target nucleic acid as a function of time includes recruiting a chromatin regulator (CR) to a site proximal to a transcription initiation site of the target nucleic acid to form a fraction of silenced cells in the population of cells. The chromatin regulator may be EED, KRAB, DNMT3, HDAC4, EZH2, REST, or a combination thereof.
    Type: Application
    Filed: April 18, 2016
    Publication date: October 20, 2016
    Inventors: Michael Elowitz, Lacramioara Bintu, John Yong