Patents by Inventor Michael Entzeroth

Michael Entzeroth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
    Patent number: 5587393
    Abstract: The invention relates to benzimidazoles of general formula ##STR1## wherein R.sub.1 to R.sub.4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are useful, in particular, as angiotensin antagonists.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: December 24, 1996
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Berthold Narr, Norbert Hauel, Jacques Van Meel, Wolfgang Wienen, Michael Entzeroth, Uwe Ries
  • Benzimidazoles and pharmaceutical compositions containing them
    Patent number: 5565469
    Abstract: Angiotensin-II inhibiting benzimidazoles, useful for the treatment of hypertension.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: October 15, 1996
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Gerhard Mihm, Norbert Hauel, Uwe Ries, Jacobus C. Antonius van Meel, Wolfgang Wienen, Michael Entzeroth
  • Benzimidazoles and medicaments containing these compounds
    Patent number: 5541229
    Abstract: The invention relates to benzimidazoles of the formula ##STR1## in which R.sub.1 to R.sub.2 are as defined in claim 1,1 and 3 isomer mixtures thereof and addition salts thereof which have valuable properties.In particular, the novel compounds are angiotensin II antagonists.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: July 30, 1996
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Berthold Narr, Andreas Bomhard, Norbert Hauel, Jacques Van Meel, Wolfgang Wienen, Michael Entzeroth
  • Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
    Patent number: 5521177
    Abstract: The invention relates to benzimidazoles of general formula ##STR1## Exemplary compounds are: (a) 4'-[[2-Ethyl-4-methyl-6-[(2-dimethylamino-3,4-dioxo-1-cyclobuten-1-yl)amin o]-1H-benzimidazol-1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl,(b) 4'-[[2-n-Propyl-4-methyl-6-(2-cyano-3,3-dimethyl-guanidino)-1H-benzimidazo l-1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl,(c) 4'-[[2-n-Propyl-4-methyl-6-(2,2-dicyano-1-dimethylamino-etheneamino)-1H-be nzimidazol -1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl,(d) 4'-[[2-n-Propyl-4-methyl-6-(1-morpholino-2-nitro-etheneamino)-1H-benzimida zol -1 -yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl, and(e) 4'-[[2-n-Propyl-4-methyl-6-(1,1-dimethylamino-2-nitro-etheneamino)-1H-benz imidazol -1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl.The new compounds are angiotensin-antagonists.
    Type: Grant
    Filed: October 4, 1993
    Date of Patent: May 28, 1996
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Uwe Ries, Norbert Hauel, Jacques van Meel, Wolfgang Wienen, Michael Entzeroth
  • Phenylalkyl derivatives, with pharmaceutical activity
    Patent number: 5519138
    Abstract: A phenylalkyl derivative of the formula ##STR1## wherein R.sub.a to R.sub.f, A and B are substituents and n is the number 0 or 1.These phenylalkyl derivatives possess angiotensin antagonist activity.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: May 21, 1996
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Uwe Ries, Manfred Reiffen, Wolfgang Grell, Norbert Hauel, Berthold Narr, Armin Heckel, Andreas Bomhard, Jacques van Meel, Wolfgang Wienen, Michael Entzeroth
  • Substituted benzimidazolyl derivatives and pharmaceutical compositions containing these compounds
    Patent number: 5459147
    Abstract: The invention relates to substituted benzimidazolyl derivatives of the general formula ##STR1## wherein A and R.sub.a to R.sub.c are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof which have valuable properties.These compounds have valuable pharmacological properties, particularly angiotensin-antagonistic effects and preferably angiotensin-II-antagonistic effects.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: October 17, 1995
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Norbert Hauel, Uwe Ries, Berthold Narr, Jacques van Meel, Wolfgang Wienen, Michael Entzeroth
  • Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
    Patent number: 5385925
    Abstract: The invention relates to benzimidazoles of general formula ##STR1## wherein R.sub.1 to R.sub.4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are useful, in particular, as angiotensin antagonists.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: January 31, 1995
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Berthold Narr, Norbert Hauel, Jacques Van Meel, Wolfgang Wienen, Michael Entzeroth, Uwe Ries
  • Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them
    Patent number: 5270322
    Abstract: Imidazo[1,2-a]pyridines of the formula ##STR1## wherein R.sub.a to R.sub.e are as defined herein, the enantiomers and the salts thereof, which are useful as angiotensin antagonists and for treating conditions treatable with angiotensin antagonists.
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: December 14, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Uwe Ries, Norbert Hauel, Berthold Narr, Jacques van Meel, Wolfgang Wienen, Michael Entzeroth
  • 2-hydroxypropylamino-alkyl-benzimidazoly-5-yl derivatives and their use in the treatment of heart disease
    Patent number: 5135932
    Abstract: The invention relates to new 2-hydroxy-n-propylamines of the formulaR.sub.1 --O--CH.sub.2 --CHOH--CH.sub.2 --NH--A--R.sub.2 (I)whereinR.sub.1, R.sub.2 and A are defined as in claim 1, the tautomers, enantiomers and acid addition salts thereof, particularly for pharmaceutical use the physiologically acceptable acid addition salts thereof with inorganic or organic acids, which have valuable pharmacological properties, more particularly a simultaneous cardiotonic and .beta.-blocking activity, and the use thereof as pharmaceutical compositions and processes for preparing them.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: August 4, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Norbert Hauel, Annerose Mauz, Jacques van Meel, Michael Entzeroth, Rainer Zimmermann, Willi Diederen
  • 4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as pharmaceutical compositions
    Patent number: 5068325
    Abstract: The present invention relates to new 4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepines of general formula II ##STR1## wherein the substituents are defined herein below, which compounds have valuable pharmacological properties, namely selective effects on the dopaminergic system which are achieved by stimulating (predominantly D2) dopamine receptors.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: November 26, 1991
    Assignee: Karl Thomae GmbH
    Inventors: Wolfgang Grell, Rudolf Hurnaus, Manfred Reiffen, Robert Sauter, Ludwig Pichler, Walter Kobinger, Michael Entzeroth, Joachim Mierau, Gunter Schingnitz