Patents by Inventor Michael Epperly

Michael Epperly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240182893
    Abstract: Disclosed herein are compositions and methods for treating and preventing a disease or condition characterized by aberrant fibroblast proliferation and extracellular matrix deposition in a tissue of a subject in need thereof. The particular disease or condition can be fibrosis, specifically, radiation-induced fibrosis. The method for treating or preventing the disease or condition can include administering to the subject an effective amount of a composition that inhibits Fgr, a non-receptor tyrosine kinase.
    Type: Application
    Filed: April 1, 2022
    Publication date: June 6, 2024
    Inventors: Amitava MUKHERJEE, Michael EPPERLY, Joel GREENBERGER
  • Publication number: 20240002350
    Abstract: Disclosed are compounds and methods for preventing or treating necroinflammation associated with ferroptotic processes. The method includes inhibiting 15 lipoxygenase/phosphatidylethanolamine binding protein (15LOX/PEBP1) complex, wherein the inhibitor exhibits a higher binding affinity or binding activity for 15LOX/PEBP1 complex compared to 15LOX alone. Necroinflammation associated with ferroptotic processes causes several pathogenic conditions including upper or lower respiratory disorders, acute or chronic brain injury, renal injury, injury by radiation, neurodegenerative disorder, among others. The disclosed compounds and methods are useful in subjects diagnosed with one or more of these conditions.
    Type: Application
    Filed: November 17, 2021
    Publication date: January 4, 2024
    Inventors: Sally Ellen MORGANROTH, Valerian KAGAN, Jinming ZHAO, Ganesha RAI, Hulya BAYIR, Yulia TYURINA, Haider DAR, Tamil ANTHONYMUTHU, Joel GREENBERGER, Michael EPPERLY, Diane LUCI, Juan MARUGAN, Anton SIMEONOV, Alexey V. ZAKHAROV, Adam YASGAR, Andrew AMOSCATO
  • Publication number: 20220362340
    Abstract: Disclosed herein are gastrointestinal tract (G1) bacteria and methods for treating or preventing an irradiation-induced intestinal damage in a subject, the methods comprising administering a G1 bacterium to the subject, wherein the G1 bacterium comprises a vector that comprises a polynucleotide encoding IL-22 and/or IFN-P, or a functional fragment thereof.
    Type: Application
    Filed: October 30, 2020
    Publication date: November 17, 2022
    Inventors: Joel Greenberger, Michael Epperly, Xichen Zhang, Jan Peter Van Pijkeren
  • Patent number: 8883852
    Abstract: Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: November 11, 2014
    Assignee: University of Pittburgh—Of the Commonwealth System of Higher Education
    Inventors: Michael Epperly, Joel Greenberger, Jianfei Jiang, Valerian Kagan, John Lazo, Peter McDonald
  • Patent number: 8822541
    Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: September 2, 2014
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Peter Wipf, Natalia A. Belikova, Jianfei Jiang, Joshua Pierce, Joel Greenberger, Michael Epperly, Valerian Kagan
  • Publication number: 20110288178
    Abstract: Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.
    Type: Application
    Filed: October 21, 2009
    Publication date: November 24, 2011
    Inventors: Michael Epperly, Joel Greenberger, Jianfei Jiang, Valerian Kagan, John Lazo, Peter McDonald
  • Publication number: 20110172214
    Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 14, 2011
    Inventors: Peter Wipf, Natalia A. Belikova, Jianfei Jiang, Joshua Pierce, Joel Greenberger, Michael Epperly, Valerian Kagan
  • Patent number: 5208008
    Abstract: A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
    Type: Grant
    Filed: November 14, 1990
    Date of Patent: May 4, 1993
    Assignee: University of Pittsburgh
    Inventors: Girish Ranadive, Howard S. Rosenzweig, Michael Epperly, William Bloomer