Patents by Inventor Michael Eugene KOPACH

Michael Eugene KOPACH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing a GIP/GLP1 dual agonist
    Patent number: 12630601
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 12, 2024
    Date of Patent: May 19, 2026
    Assignee: ELI LILLY AND COMPANY
    Inventors: Stephanie Ruth Coffin, Michael Eugene Kopach
  • Process for preparing a GIP/GLP1 dual agonist
    Patent number: 12624079
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: May 12, 2026
    Assignee: ELI LILLY AND COMPANY
    Inventors: Michael Oliver Frederick, Michael Eugene Kopach, Sergey Vladimirovich Tsukanov
  • PEPTIDES FOR INCRETIN SYNTHESIS
    Publication number: 20260125423
    Abstract: Provided are crystalline forms of peptide fragments, method of preparation thereof, and use thereof for preparing peptides. The present crystalline compounds may be employed as intermediates with improved purity and physical properties for peptide syntheses.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 7, 2026
    Inventors: David Andrew COATES, Emily Jeannette GUINN, Ankur JALAN, Youngsun KIM, Michael Edward KOBIERSKI, Michael Eugene KOPACH, Jeremy Miles MERRITT, Emily Suzanne MURZINSKI, Jon Gordon SELBO, Jing TENG, Jingyao WANG
  • PROCESS FOR PREPARING A GIP/GLP1 DUAL AGONIST
    Publication number: 20250382345
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 16, 2025
    Publication date: December 18, 2025
    Inventors: Stephanie Ruth COFFIN, Michael Oliver FREDERICK, Ankur JALAN, Neil John KALLMAN, Michael Eugene KOPACH, Kevin Dale SEIBERT, Sergey Vladimirovich TSUKANOV
  • PROCESS FOR PREPARING A GIP/GLP1 DUAL AGONIST
    Publication number: 20250289862
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 30, 2025
    Publication date: September 18, 2025
    Inventors: Stephanie Ruth COFFIN, Michael Oliver FREDERICK, Ankur JALAN, Neil John KALLMAN, Michael Eugene KOPACH, Kevin Dale SEIBERT, Sergey Vladimirovich TSUKANOV
  • PROCESS FOR PREPARING A GIP/GLP1 DUAL AGONIST
    Publication number: 20250270276
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 14, 2025
    Publication date: August 28, 2025
    Inventors: Stephanie Ruth COFFIN, Michael Oliver FREDERICK, Ankur JALAN, Neil John KALLMAN, Michael Eugene KOPACH, Kevin Dale SEIBERT, Sergey Vladimirovich TSUKANOV
  • PROCESS FOR PREPARING A GIP/GLP1 DUAL AGONIST
    Publication number: 20250270277
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 14, 2025
    Publication date: August 28, 2025
    Inventors: Stephanie Ruth COFFIN, Michael Oliver FREDERICK, Ankur JALAN, Neil John KALLMAN, Michael Eugene KOPACH, Kevin Dale SEIBERT, Sergey Vladimirovich TSUKANOV
  • PROCESSES AND INTERMEDIATES FOR PREPARING TIRZEPATIDE
    Publication number: 20250243256
    Abstract: The present invention provides new intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 10, 2025
    Publication date: July 31, 2025
    Inventors: Michael Eugene KOPACH, Rachel Nicole RICHEY, Mark Richard BERGLUND, Kevin Dale SEIBERT, Emily Suzanne MURZINSKI
  • COMPOUNDS AND METHODS FOR LIQUID PHASE SYNTHESIS
    Publication number: 20250188019
    Abstract: The present disclosure comprises hydrophilic linker compounds of Formula 1: and describes methods for their use in liquid phase synthesis. In Formula 1, “m” is 0 to 20, “n” is 1 to 50, and “Z” is a linker compound as described herein.
    Type: Application
    Filed: August 23, 2022
    Publication date: June 12, 2025
    Inventors: Michael Eugene KOPACH, John LEE, Emily Suzanne MURZINSKI, Vineeta RUSTAGI, Heba Azmy Fahim Ibrahim SALIM
  • PROCESSES AND INTERMEDIATES FOR PREPARING TIRZEPATIDE
    Publication number: 20240400636
    Abstract: The present invention provides new intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 15, 2024
    Publication date: December 5, 2024
    Inventors: Michael Eugene KOPACH, Rachel Nicole RICHEY, Mark Richard BERGLUND, Kevin Dale SEIBERT, Emily Suzanne MURZINSKI
  • PROCESS FOR PREPARING A GIP/GLP1 DUAL AGONIST
    Publication number: 20240391975
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 12, 2024
    Publication date: November 28, 2024
    Inventors: Stephanie Ruth COFFIN, Michael Eugene KOPACH, Kevin Dale SEIBERT
  • PROCESS FOR PREPARING A GIP/GLP1 DUAL AGONIST
    Publication number: 20240368240
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 24, 2024
    Publication date: November 7, 2024
    Inventors: Stephanie Ruth COFFIN, Michael Oliver FREDERICK, Ankur JALAN, Neil John KALLMAN, Michael Eugene KOPACH, Kevin Dale SEIBERT, Sergey Vladimirovich TSUKANOV
  • PROCESS FOR PREPARING A GLP-1/GLUCAGON DUAL AGONIST
    Publication number: 20230220000
    Abstract: The present invention provides processes and compounds for the preparation of glucagon and GLP-1 co-agonist compounds that are useful in the treatment of type 2 diabetes, obesity, nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH).
    Type: Application
    Filed: June 11, 2021
    Publication date: July 13, 2023
    Inventors: Michael Edward KOBIERSKI, Michael Eugene KOPACH
  • METHODS OF MAKING INCRETIN ANALOGS
    Publication number: 20220411461
    Abstract: Intermediate compounds are disclosed for making incretin analogs, or pharmaceutically acceptable salts thereof. In addition, methods are disclosed for making incretin analogs by coupling from two to four of the intermediate compounds herein via hybrid liquid solid phase synthesis or native chemical ligation.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 29, 2022
    Inventors: Michael Eugene Kopach, Yu Lu, Sergey Vladimirovich Tsukanov, Timothy Donald White, Ankur Jalan, Jinju James, Michael E. Kobierski
  • PROCESS FOR PREPARING A GIP/GLP1 DUAL AGONIST
    Publication number: 20220135639
    Abstract: The present invention provides novel intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 28, 2020
    Publication date: May 5, 2022
    Inventors: Stephanie Ruth COFFIN, Michael Oliver FREDERICK, Ankur JALAN, Neil John KALLMAN, Michael Eugene KOPACH, Kevin Dale SEIBERT, Sergey Vladimirovich TSUKANOV