Abstract: Disclosed is an environmentally sensitive ratiometric reporter molecule. The molecule is a compound of Formula (I) wherein D1 and D2 are detectable molecules and D1 is a reference molecule; D2 is an environmentally sensitive molecule; and L is a linker group.

Abstract: A container closure system such that an uninstructed person would find it difficult to remove the closure. Helical screw threads on the container and on the one-piece closure have detents and discrete thread portions engageable under the influence of a spring means once the closure has been screwed onto (cap) or into (stopper) the container to a certain extent. Unscrewing can only be effected by firstly overcoming the spring means to separate the locking detents/thread portions and subsequently turning the closure while continuing to overcome said spring means.