Abstract: Aspects related to a resource-constrained system are described herein that can provide object storage services after a service interruption is resolved, even if all of the transactions that were pending and incomplete prior to the service interruption have not yet been recovered and/or executed. For example, file systems implemented by computing systems of the resource-constrained system may treat each file or directory as a separate object. Thus, a transaction directed to one file may not affect the file's directory or other files in the directory. As a result, the resource-constrained system can achieve read-after-write consistency without first recovering and executing the pending, incomplete transactions. Instead, read-after-write consistency for an object can be achieved simply by completing any pending, incomplete transaction directed to that object.

Abstract: Aspects related to a resource-constrained system are described herein that can provide object storage services after a service interruption is resolved, even if all of the transactions that were pending and incomplete prior to the service interruption have not yet been recovered and/or executed. For example, file systems implemented by computing systems of the resource-constrained system may treat each file or directory as a separate object. Thus, a transaction directed to one file may not affect the file's directory or other files in the directory. As a result, the resource-constrained system can achieve read-after-write consistency without first recovering and executing the pending, incomplete transactions. Instead, read-after-write consistency for an object can be achieved simply by completing any pending, incomplete transaction directed to that object.

Abstract: A method for generating detergent-solubilized G-protein coupled receptors (GPCRs) in powdered form. The powdered GPCRs is storable at temperatures of ?20° C. or lower and for durations of 365 days or longer without substantial loss of functionality of the GPCRs after rehydration as compared to a pre-frozen state. The method can maintain minimal detergent to protein ratio in molar concentrations. The method can further generate GPCRs with specific water or deuterium content as required in certain experiments, such as mass spectrometry, NMR spectroscopy, or quasi-elastic neutron scattering (QENS).

Abstract: A computer-implemented method of enabling distributed computers to communicate more effectively in an enterprise that provides flexible approval notifications in an organization, wherein at least one of the distributed computers stores a graph database in which attributes regarding individuals of the organization are stored. The computer-implemented method includes receiving, at a server computer in the distributed computers, a request for a task to be performed, wherein the task requires approval by at least a first person in the organization who has authority to approve the request. The computer-implemented method also includes traversing, by the server computer, the graph database, to determine an identity of the first person, wherein traversing is performed based on criteria determined at least partially by information automatically extracted from the request.

Abstract: A file synchronization service generates a listing of files stored on a local data volume by executing a plurality of threads corresponding to directories of the data volume. Files to synchronize with a remote data storage service are identified based on comparison of the listed files with cached data indicative of files stored by the remote data storage service. A plurality of file synchronization requests are sent to the remote data storage service, where the plurality of files are sent in an order that is determined at least partly based on a scaling characteristic of the remote data storage service.

Abstract: A method for generating detergent-solubilized G-protein coupled receptors (GPCRs) in powdered form. The powdered GPCRs is storable at temperatures of ?20° C. or lower and for durations of 365 days or longer without substantial loss of functionality of the GPCRs after rehydration as compared to a pre-frozen state. The method can maintain minimal detergent to protein ratio in molar concentrations. The method can further generate GPCRs with specific water or deuterium content as required in certain experiments, such as mass spectrometry, NMR spectroscopy, or quasi-elastic neutron scattering (QENS).

Abstract: A method for generating detergent-solubilized G-protein coupled receptors (GPCRs) in powdered form. The powdered GPCRs is storable at temperatures of ?20° C. or lower and for durations of 365 days or longer without substantial loss of functionality of the GPCRs after rehydration as compared to a pre-frozen state. The method can maintain minimal detergent to protein ratio in molar concentrations. The method can further generate GPCRs with specific water or deuterium content as required in certain experiments, such as mass spectrometry, NMR spectroscopy, or quasi-elastic neutron scattering (QENS).

Abstract: A computer-implemented method of enabling distributed computers to communicate more effectively in an enterprise that provides flexible approval notifications in an organization, wherein at least one of the distributed computers stores a graph database in which attributes regarding individuals of the organization are stored. The computer-implemented method includes receiving, at a server computer in the distributed computers, a request for a task to be performed, wherein the task requires approval by at least a first person in the organization who has authority to approve the request. The computer-implemented method also includes traversing, by the server computer, the graph database, to determine an identity of the first person, wherein traversing is performed based on criteria determined at least partially by information automatically extracted from the request.

Abstract: Systems and methods for managing data input/output operations are described that include virtual machines operating with a shared storage within a host. In such a system, a computer-implemented method is provided for dynamically provisioning cache storage while operating system applications continue to operate, including stalling the virtual machine's local cache storage operations, changing the provision of cache storage size; and resuming the operations of the virtual machine.

Abstract: A storage module may be configured to service I/O requests according to different persistence levels. The persistence level of an I/O request may relate to the storage resource(s) used to service the I/O request, the configuration of the storage resource(s), the storage mode of the resources, and so on. In some embodiments, a persistence level may relate to a cache mode of an I/O request. I/O requests pertaining to temporary or disposable data may be serviced using an ephemeral cache mode. An ephemeral cache mode may comprise storing I/O request data in cache storage without writing the data through (or back) to primary storage. Ephemeral cache data may be transferred between hosts in response to virtual machine migration.

Abstract: A storage module may be configured to service I/O requests according to different persistence levels. The persistence level of an I/O request may relate to the storage resource(s) used to service the I/O request, the configuration of the storage resource(s), the storage mode of the resources, and so on. In some embodiments, a persistence level may relate to a cache mode of an I/O request. I/O requests pertaining to temporary or disposable data may be serviced using an ephemeral cache mode. An ephemeral cache mode may comprise storing I/O request data in cache storage without writing the data through (or back) to primary storage. Ephemeral cache data may be transferred between hosts in response to virtual machine migration.

Abstract: A virtual machine cache provides for maintaining a working set of the cache during a transfer between virtual machine hosts. In response to a virtual machine transfer, the previous host of the virtual machine is configured to retain cache data of the virtual machine, which may include both cache metadata and data that has been admitted into the cache. The cache data may be transferred to the destination host via a network (or other communication mechanism). The destination host populates a virtual machine cache with the transferred cache data to thereby reconstruct the working state of the cache.

Abstract: A method for generating detergent-solubilized G-protein coupled receptors (GPCRs) in powdered form. The powdered GPCRs is storable at temperatures of ?20° C. or lower and for durations of 365 days or longer without substantial loss of functionality of the GPCRs after rehydration as compared to a pre-frozen state. The method can maintain minimal detergent to protein ratio in molar concentrations. The method can further generate GPCRs with specific water or deuterium content as required in certain experiments, such as mass spectrometry, NMR spectroscopy, or quasi-elastic neutron scattering (QENS).

Abstract: A cache log module stores an ordered log of cache storage operations sequentially within the physical address space of a non-volatile storage device. The log may be divided into segments, each comprising a set of log entries. Data admitted into the cache may be associated with respective log segments. Cache data may be associated with the log segment that corresponds to the cache storage operation in which the cache data was written into the cache. The backing store of the data may be synchronized to a particular log segment by identifying the cache data pertaining to the segment (using the associations), and writing the identified data to the backing store. Data lost from the cache may be recovered from the log by, inter alia, committing entries in the log after the last synchronization time of the backing store.

Abstract: A de-duplication is configured to cache data for access by a plurality of different storage clients, such as virtual machines. A virtual machine may comprise a virtual machine de-duplication module configured to identify data for admission into the de-duplication cache. Data admitted into the de-duplication cache may be accessible by two or more storage clients. Metadata pertaining to the contents of the de-duplication cache may be persisted and/or transferred with respective storage clients such that the storage clients may access the contents of the de-duplication cache after rebooting, being power cycled, and/or being transferred between hosts.

Abstract: Systems and methods for managing data input/output operations are described. In one aspect, a device driver identifies a data read operation generated by a virtual machine in a virtual environment. The device driver is located in the virtual machine and the data read operation identifies a physical cache address associated with the data requested in the data read operation. A determination is made regarding whether data associated with the data read operation is available in a cache associated with the virtual machine.

Abstract: A multi-level cache comprises a plurality of cache levels, each configured to cache I/O request data pertaining to I/O requests of a different respective type and/or granularity. The multi-level cache may comprise a file-level cache that is configured to cache I/O request data at a file-level of granularity. A file-level cache policy may comprise file selection criteria to distinguish cacheable files from non-cacheable files. The file-level cache may monitor I/O requests within a storage stage, and may service I/O requests from a cache device.

Abstract: A multi-level cache comprises a plurality of cache levels, each configured to cache I/O request data pertaining to I/O requests of a different respective type and/or granularity. The multi-level cache may comprise a file-level cache that is configured to cache I/O request data at a file-level of granularity. A file-level cache policy may comprise file selection criteria to distinguish cacheable files from non-cacheable files. The file-level cache may monitor I/O requests within a storage stage, and may service I/O requests from a cache device.

Abstract: Systems and methods for managing data input/output operations are described that include virtual machines operating with a shared storage within a host. In such a system, a computer-implemented method is provided for dynamically provisioning cache storage while operating system applications continue to operate, including stalling the virtual machine's local cache storage operations, changing the provision of cache storage size; and resuming the operations of the virtual machine.

Abstract: A de-duplication is configured to cache data for access by a plurality of different storage clients, such as virtual machines. A virtual machine may comprise a virtual machine de-duplication module configured to identify data for admission into the de-duplication cache. Data admitted into the de-duplication cache may be accessible by two or more storage clients. Metadata pertaining to the contents of the de-duplication cache may be persisted and/or transferred with respective storage clients such that the storage clients may access the contents of the de-duplication cache after rebooting, being power cycled, and/or being transferred between hosts.