Patents by Inventor Michael F. Crowley

Michael F. Crowley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cellobiohydrolase I enzymes
    Patent number: 8637293
    Abstract: Provided herein is an isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide, wherein the mutations reduce N-linked glycosylation of the isolated polypeptide relative to the wild type polypeptide. Also provided herein is an isolated Cel7A polypeptide comprising increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide. The increased O-linked glycosylation is a result of the addition of and/or substitution of one or more serine and/or threonine residues to the linker domain relative to the linker domain of the wild type polypeptide. In some embodiments, the isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide further comprises increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: January 28, 2014
    Assignee: Alliance for Sustainable Energy, LLC
    Inventors: William S. Adney, Michael E. Himmel, Stephen R. Decker, Eric P. Knoshaug, Mark R. Nimlos, Michael F. Crowley, Tina Jeoh
  • CELLOBIOHYDROLASE I ENZYMES
    Publication number: 20090162916
    Abstract: Provided herein is an isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide, wherein the mutations reduce N-linked glycosylation of the isolated polypeptide relative to the wild type polypeptide. Also provided herein is an isolated Cel7A polypeptide comprising increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide. The increased O-linked glycosylation is a result of the addition of and/or substitution of one or more serine and/or threonine residues to the linker domain relative to the linker domain of the wild type polypeptide. In some embodiments, the isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide further comprises increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide.
    Type: Application
    Filed: May 19, 2008
    Publication date: June 25, 2009
    Applicant: Alliance for Sustainable Energy, LLC
    Inventors: William S. Adney, Michael E. Himmel, Stephen R. Decker, Eric P. Knoshaug, Mark R. Nimlos, Michael F. Crowley, Tina Jeoh