Patents by Inventor Michael F. Czarniecki
Michael F. Czarniecki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130196986Abstract: The invention provides certain 3,7-disubstituted-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-ones of the Formula (I), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R8, and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating pain or an inflammatory disease.Type: ApplicationFiled: September 16, 2011Publication date: August 1, 2013Inventors: Marc Labroli, Michael F. Czarniecki, Cory Seth Poker
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Patent number: 8349858Abstract: The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.Type: GrantFiled: June 18, 2008Date of Patent: January 8, 2013Assignee: Merck Sharp & DohmeInventors: Deen Tulshian, William B. Geiss, Gregory S. Martin, Van-Duc Le, James C. Haber, Jr., Julius J. Matasi, Michael F. Czarniecki, Stephanie Nicole Cooke
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Publication number: 20120316176Abstract: The present invention relates to derivatives of 7,8-dihydro-1H-imidazo[2,1-b]purin-4(5H)-one, compositions thereof and methods of use thereof for treating or preventing pain or an inflammatory disease.Type: ApplicationFiled: December 16, 2010Publication date: December 13, 2012Inventors: Deen Tulshian, Michael F. Czarniecki, Julius Matasi, Stephanie N. Brumfield
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Publication number: 20110065738Abstract: The present invention relates to Polycyclic Guanine Derivatives, compositions comprising the Polycyclic Guanine Derivatives and methods of using the Polycyclic Guanine Derivatives to treat pain or an inflammatory disease.Type: ApplicationFiled: June 18, 2008Publication date: March 17, 2011Inventors: Deen Tulshian, William B. Geiss, Gregory S. Martin, Van-Duc Le, James C. Haber, JR., Julius J. Matasi, Michael F. Czarniecki, Stephanie Nicole Cooke
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Patent number: 6903123Abstract: Disclosed are nociceptin ORL-1 receptor agonists of the formula wherein: (a) R1 is optionally substituted alkyl, fluorenyl, pyrimidinyl or optionally substituted piperidinyl; R2 is H; and R3 is —C(H)(R)—NR7R8; R is H, optionally substituted aryl or arylalkyl, or heteroaryl; R7 is —(CH2)xR9, optionally substituted tetrahydronaphthyl, or cycloalkyl; and R8 is H; or R7 and R8 together form a substituted piperidinyl or piperazinyl ring; x is 0-10; and R9 is H, alkoxy, optionally substituted phenyl, naphthyl, heteroaryl, pyrrolidinyl, pyrrolidonyl, optionally substituted piperidinyl or diphenylmethyl; or (b) R2 is —NHR7 or and R3 is H; pharmaceutical compositions; and methods of using the compounds to treat cough and pain.Type: GrantFiled: February 3, 2004Date of Patent: June 7, 2005Assignee: Schering CorporationInventors: Duane A. Burnett, Mary Ann Caplen, Michael F. Czarniecki, Martin S. Domalksi, Ginny D. Ho, Deen Tulshian, Wen-Lian Wu
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Publication number: 20040157822Abstract: Disclosed are nociceptin ORL-1 receptor agonists of the formula 1Type: ApplicationFiled: February 3, 2004Publication date: August 12, 2004Inventors: Duane A. Burnett, Mary Ann Caplen, Michael F. Czarniecki, Martin S. Domalksi, Ginny D. Ho, Deen Tulshian, Wen-Lian Wu
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Publication number: 20030195185Abstract: Disclosed are nociceptin ORL-1 receptor agonists of the formula 1Type: ApplicationFiled: November 14, 2002Publication date: October 16, 2003Applicant: Schering CorporationInventors: Duane A. Burnett, Mary Ann Caplen, Michael F. Czarniecki, Martin S. Domalksi, Ginny D. Ho, Deen Tulshian, Wen-Lian Wu
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Patent number: 6326380Abstract: Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt thereof, wherein: the single dotted line represents an optional double bond; the double dotted line represents an optional single bond; n is 0-2; Q is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; Het is an optionally substituted mono-, bi- or tricyclic heteroaromatic group; B is —(CH2)n3—, wherein n3 is 0-5, —CH2—O—, —CH2S—, —CH2—NR6—, —C(O)NR6—, —NR6C(O)—, optionally substituted alkenyl or optionally substituted alkynyl; X is —O— or —NR6— when the double dotted line represents a single bond, or X is —OH or —NHR20 when the bond is absent; Y is ═O, ═S, (H, H), (H, OH) or (H, C1-C6 alkoxy) when the double dotted line represents a single bond, or when the bond is absent, Y is ═O, (H, H), (H, OH), (H, SH) or (H, C1-CType: GrantFiled: April 7, 2000Date of Patent: December 4, 2001Assignee: Schering CorporationInventors: Samuel Chackalamannil, Theodros Asberom, Yan Xia, Dario Doller, Martin C. Clasby, Michael F. Czarniecki
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Patent number: 6063847Abstract: Heterocyclic-substituted tricyclics of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: the single dotted line represents an optional double bond;the double dotted line represents an optional single bond;n is 0-2;Q is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl;Het is an optionally substituted mono-, bi- or tricyclic heteroaromatic group;B is --(CH.sub.2).sub.n3 --, wherein n.sub.3 is 0-5, --CH.sub.2 --O--, --CH.sub.2 S--, --CH.sub.2 --NR.sup.6 --, --C(O)NR.sup.6 --. --NR.sup.6 C(O)--, ##STR2## optionally substituted alkenyl or optionally substituted alkynyl; X is --O-- or --NR.sup.6 -- when the double dotted line represents a single bond, or X is --OH or --NHR.sup.20 when the bond is absent;Y is .dbd.O, .dbd.S, (H, H), (H, OH) or (H, C.sub.1 -C.sub.6 alkoxy) when the double dotted line represents a single bond, or when the bond is absent, Y is .dbd.O, (H, H), (H, OH), (H, SH) or (H, C.sub.1 -C.sub.6 alkoxy);R.sup.Type: GrantFiled: November 23, 1998Date of Patent: May 16, 2000Assignee: Schering CorporationInventors: Samuel Chackalamannil, Theodros Asberom, Yan Xia, Dario Doller, Martin C. Clasby, Michael F. Czarniecki
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Patent number: 5476847Abstract: Phosphinic acid derivatives of the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is H, alkyl or alkanoyloxymethylene;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H, alkyl, alkenyl, alkenylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, hydroxyalkyl, carboxyalkyl, thioalkyl, alkoxythioalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl-substituted alkyl or heterocycloalkyl; or R.sub.1 and R.sub.2 form a cycloalkyl ring of 3-8 members and R.sub.3 and R.sub.4 are as defined; or R.sub.3 and R.sub.4 form a cycloalkyl ring of 3-7 members and R.sub.1 and R.sub.2 are as defined; or R.sub.1 and R.sub.2 together, and R.sub.3 and R.sub.4 together, each form a cycloalkyl ring;R.sub.5 is --OR.sub.9 or --NHR.sub.9, wherein R.sub.9 is hydrogen or alkyl;n is 0 or 1;A.sub.1 is p-aminobenzoyl or p-aminobenzenesulfonyl, or A.sub.1 and R.sub.5 together form a radical of an .alpha.-aminoacyl derivative; andR.sub.6 is phenylmethoxycarbonyl, arylcarbonyl, heteroarylcarbonyl or --A.sub.2 --R.sub.Type: GrantFiled: June 29, 1994Date of Patent: December 19, 1995Assignee: Schering CorporationInventors: Brian A. McKittrick, Michael F. Czarniecki, Samuel Chackalamannil, Shin Chung, Shawn DeFrees, Andrew W. Stamford
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Patent number: 5047399Abstract: Novel hydrophobic psuedo-peptides of formula I ##STR1## wherein R.sub.1 is lower alkyl or -CH.sub.2 CONR.sub.6 R.sub.7 ; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently lower alkyl, cycloalkyl lower alkyl, aryl lower alkyl, heteroaryl lower alkyl, aryl lower alkoxy, substituted aryl lower alkyl, wherein the aryl portion is substituted with 1-3 substituents independently selected from lowr alkyl, hydroxyl, lower alkoxy and halogeno, substituted heteroaryl lower alkyl wherein the substituents on the heteroaryl portion are as defined for aryl lower alkyl, substituted cycloalkyl lower alkyl, wherein the substituents on the cycloalkyl portion are as defined for aryl lower alkyl, and substituted aryl lower alkoxy wherein the substituents are as defined for aryl lower alkyl;R.sub.6 and R.sub.7 are independently hydrogen or lower alkyl;X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 are independently ##STR2## cis or trans --CR.sub.8 .dbd.CR.sub.9 --, --CHR.sub.8 CHR.sub.9 --, --CH.sub.2 NR.sub.Type: GrantFiled: July 13, 1988Date of Patent: September 10, 1991Assignee: Schering CorporationInventors: Laura S. Lehman, Michael F. Czarniecki
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Patent number: 4921941Abstract: Antiandrogenic peptidyl esters, particularly tri-peptidyl esters, of the active metabolite of flutamide are disclosed.Type: GrantFiled: July 1, 1987Date of Patent: May 1, 1990Assignee: Schering CorporationInventors: Tattanahalli L. Nagabhushan, Martin F. Haslanger, Michael F. Czarniecki
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Patent number: 4857301Abstract: Certain substituted sulfonamide quinolines and isoquinolines are disclosed having anti-allergic activity. A preferred use is for the treatment of chronic obstructive lung disease, and in particular, asthma.Type: GrantFiled: September 25, 1987Date of Patent: August 15, 1989Assignee: Schering CorporationInventors: Michael F. Czarniecki, Barr E. Bauer
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Patent number: 4766109Abstract: Hydrophobic peptides having antihypertensive activity are disclosed. Also disclosed are pharmaceutical compositions comprising a hydrophobic peptide and a method of treatment of mammalian hypertension comprising administering a hydrophobic peptide to a hypertensive mammal.Type: GrantFiled: October 17, 1986Date of Patent: August 23, 1988Assignee: Schering CorporationInventors: Michael F. Czarniecki, Laura L. Verbiar, Timothy Kogan
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Patent number: 4634689Abstract: Phosphinylalkanoyl imino acids useful in the treatment of hypertension are disclosed.Type: GrantFiled: October 31, 1985Date of Patent: January 6, 1987Assignee: Schering CorporationInventors: Joseph T. Witkowski, Michael F. Czarniecki