Patents by Inventor Michael F. Gross

Michael F. Gross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclo inhibitors of potassium channel function
    Publication number: 20040110793
    Abstract: Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: April 16, 2003
    Publication date: June 10, 2004
    Inventors: John Lloyd, Yoon T. Jeon, Heather Finlay, Lin Yan, Michael F. Gross, Serge Beaudoin
  • Benzanilides as potassium channel openers
    Patent number: 6737422
    Abstract: Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: May 18, 2004
    Assignee: ICAgen, Inc.
    Inventors: Grant A. McNaughton-Smith, Michael F. Gross, Alan D. Wickenden
  • Cycloalkyl inhibitors of potassium channel function
    Publication number: 20040072880
    Abstract: Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: January 31, 2003
    Publication date: April 15, 2004
    Inventors: John Lloyd, Yoon T. Jeon, Heather Finlay, Lin Yan, Michael F. Gross, Serge Beaudoin
  • Potassium channel inhibitors and method
    Publication number: 20040067944
    Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure 1
    Type: Application
    Filed: November 15, 2002
    Publication date: April 8, 2004
    Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear
  • Potassium channel inhibitors and method
    Publication number: 20040058931
    Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure 1
    Type: Application
    Filed: November 15, 2002
    Publication date: March 25, 2004
    Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear
  • Pyrazolopyrimidines
    Publication number: 20030176450
    Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 18, 2003
    Applicant: Icagen, Inc.
    Inventors: Robert N. Atkinson, Michael F. Gross, Albert M. van Rhee
  • Potassium channel inhibitors
    Patent number: 6620849
    Abstract: Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: September 16, 2003
    Assignee: ICAFEN, Inc.
    Inventors: Serge Beaudoin, Michael F. Gross, Aimee D. Reed, Alan D. Wickenden, Anrou Zou
  • Piperidines
    Publication number: 20030171360
    Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 11, 2003
    Applicant: Icagen, Inc.
    Inventors: Michael F. Gross, Robert N. Atkinson, Matthew S. Johnson
  • Benzanilides as potassium channel openers
    Patent number: 6605725
    Abstract: Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: August 12, 2003
    Assignee: ICAgen, Inc.
    Inventors: Grant A. McNaughton-Smith, Michael F. Gross, Alan D. Wickenden
  • Potassium channel inhibitors and method
    Patent number: 6511977
    Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: January 28, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear
  • Potassium channel inhibitors
    Publication number: 20020169161
    Abstract: Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
    Type: Application
    Filed: July 24, 2001
    Publication date: November 14, 2002
    Inventors: Serge Beaudoin, Michael F. Gross, Aimee D. Reed, Alan Wickenden, Anrou Zou
  • Potassium channel inhibitors
    Publication number: 20020161011
    Abstract: Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
    Type: Application
    Filed: December 7, 2001
    Publication date: October 31, 2002
    Applicant: ICAgen
    Inventors: Serge Beaudoin, Aimee D. Reed, Michael F. Gross
  • Benzanilides as potassium channel openers
    Publication number: 20020091122
    Abstract: Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
    Type: Application
    Filed: December 6, 2001
    Publication date: July 11, 2002
    Applicant: Icagen, Inc.
    Inventors: Grant A. McNaughton-Smith, Michael F. Gross, Alan D. Wickenden
  • Potassium channel inhibitors
    Patent number: 6395730
    Abstract: Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases, conditions and disorders.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: May 28, 2002
    Assignees: Icagen, Inc., Eli Lilly and Company
    Inventors: Michael F. Gross, Neil A. Castle, Jose S. Mendoza
  • Benzanilides as potassium channel openers
    Publication number: 20020052393
    Abstract: Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
    Type: Application
    Filed: November 2, 2001
    Publication date: May 2, 2002
    Applicant: Icagen, Inc.
    Inventors: Grant A. McNaughton-Smith, Michael F. Gross, Alan D. Wickenden
  • Benzanilides as potassium channel openers
    Patent number: 6372767
    Abstract: Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: April 16, 2002
    Assignee: Icagen, Inc.
    Inventors: Grant A. McNaughton-Smith, Michael F. Gross, Alan D. Wickenden
  • Potassium channel inhibitors
    Patent number: 6333337
    Abstract: Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: December 25, 2001
    Assignee: ICAgen, Inc.
    Inventors: Michael F. Gross, Neil A. Castle
  • Potassium channel inhibitors
    Patent number: 6174908
    Abstract: Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases, conditions and disorders.
    Type: Grant
    Filed: May 1, 1999
    Date of Patent: January 16, 2001
    Assignees: ICAGen, Inc., Eli Lilly & Company Lilly Corporate Center
    Inventors: Michael F. Gross, Neil A. Castle, Jose S. Mendoza
  • Potassium channel inhibitors and method
    Patent number: 6150356
    Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X.sup.1, R, R.sup.1, X.sup.2 and R.sup.2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: November 21, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear