Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: This disclosure relates to the unique integration of a plurality of thermodynamic cycles comprised of a supercritical carbon dioxide thermodynamic cycle, one or more other thermodynamic cycles with multiple heat sources derived from nuclear fuel, solar energy, hydrogen, and fossil fuels, with the energy production systems configured to noticeably improve power plant efficiency, cost and performance.

Abstract: This disclosure relates to the unique integration of a plurality of thermodynamic cycles comprised of a supercritical carbon dioxide thermodynamic cycle, one or more other thermodynamic cycles with multiple heat sources derived from nuclear fuel, solar energy, hydrogen, and fossil fuels, with the energy production systems configured to noticeably improve power plant efficiency, cost and performance.

Abstract: Disclosed is an advanced process that relates to the enhanced production of energy using the integration of multiple thermal cycles (Brayton and Rankine) that employ multiple fuels, multiple working fluids, turbines and equipment. The method includes providing a nuclear reactor, reactor working fluid, heat exchangers, compressors, and multiple turbines to drive compressors that pressurize a humidified working fluid that is combusted with fuel fired in at least one gas turbine. The turbine(s) provide for electrical energy, processes or other mechanical loads.

Abstract: Disclosed is an advanced process that relates to the enhanced production of energy using the integration of multiple thermal cycles (Brayton and Rankine) that employ multiple fuels, multiple working fluids, turbines and equipment. The method includes providing a nuclear reactor, reactor working fluid, heat exchangers, compressors, and multiple turbines to drive compressors that pressurize a humidified working fluid that is combusted with fuel fired in at least one gas turbine. The turbine(s) provide for electrical energy, processes or other mechanical loads.