Patents by Inventor Michael F. Lipton

Michael F. Lipton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-hygroscopic adinazolam methanesulfonate salt and process therefor
    Patent number: 4684725
    Abstract: Crystalline, non-hygroscopic adinazolam methanesulfonate, per se, preparable from xylene or preferably from a C.sub.1 to C.sub.2 -alkanol/C.sub.4 to C.sub.6 -alkyl acetate liquid mixture, aids processability of adinazolam methanesulfonate in pharmaceutical production plants.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: August 4, 1987
    Assignee: The Upjohn Company
    Inventors: Burris D. Tiffany, Steve Nichols, Paul A. Meulman, Thomas A. Hylton, Michael F. Lipton
  • Preparing 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepines in improved procedures
    Patent number: 4474699
    Abstract: An improved process for preparing a 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepine product, e.g., adinazolam, directly from the corresponding 1-hydrogen-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepine starting material, e.g., from estazolam, by conducting the reaction between the estazolam-type compound and the dimethylaminomethylene salt in the selected solvent in the presence of an alkali metal carbonate, and thereafter extracting the 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine from an aqueous organic solvent mixture thereof into a halogenated C.sub.1 to C.sub.3 -alkane solvent while maintaining the pH of the aqueous phase between pH 3.0 and 4.0, and thereafter recovering the product from the halogenated alkane solvent.
    Type: Grant
    Filed: May 25, 1983
    Date of Patent: October 2, 1984
    Assignee: The Upjohn Company
    Inventors: Donald J. Cram, Martin Gall, Michael F. Lipton