Patents by Inventor Michael F. Scully

Michael F. Scully has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serine protease inhibitors compromising a hydrogen-bond acceptor
    Publication number: 20040235792
    Abstract: Compounds, useful as protease inhibitors, of the formula (I): where: Ar is a ring or ring system, for example a benzene ring, and may be substituted by one or more moieties in addition to X and LJ; X is a functional group which is a hydrogen-bond acceptor, e.g. a nitro or boronate group BY1Y2; L is a linker, most preferably (CR5R6)—S—; J is a moiety containing a basic nitrogen atom but not containing an amino acid residue, preferably amidino, guanidine, amino carboxamido, hydroxylamino, or imidazolyl, or an N-substituted analogue thereof.
    Type: Application
    Filed: December 18, 2003
    Publication date: November 25, 2004
    Inventors: John J Deadman, John Spencer, Paulette A Greenidge, Christopher A Goodwin, Vijay Vir Kakkar, Michael F Scully, Richard Jones Holland
  • Bi-or multifunctional molecules based on a dendroaspin scaffold
    Patent number: 6451976
    Abstract: Dendroaspin, a polypeptide neurotoxin analogue is modified by recombinant DNA techniques, particularly “loop grafting” to provide a modified polypeptide. The modified polypeptide is constructed so as to retain dendroaspin activity, for example, platelet adhesion to fibrinogen, in addition to possessing one or more further biological or biochemical activities not native to dendroaspin, for example, platelet derived growth factor (PDGF) activity or hirudin activity.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: September 17, 2002
    Assignee: Trigen Limited
    Inventors: Xinjie Lu, Michael F. Scully, Vijay V. Kakkar, Kalwant S. Authi
  • Antithrombotic composition
    Patent number: 5576304
    Abstract: A pharmaceutical composition comprising dermatan sulphate, together with a low molecular weight heparin, free or fixed combination, is useful as a antithrombolytic agent with a low risk of bleeding complications.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: November 19, 1996
    Assignee: Thrombosis Research Institute
    Inventors: Vijay V. Kakkar, Michael F. Scully