Abstract: A device is disclosed for compounding two solutions contained in cartridges, where one of the cartridges serves as the mixing vessel. The device can be used for buffering anesthetic prior to use by a medical practitioner, including, but not limited to, dentists buffering local anesthetic prior to use. In various embodiments, a container of buffering solution can be incorporated into the device, which will maintain the buffer in a stable condition. The device can be used to buffer anesthetic in one or more cartridges and when the buffer in the device is exhausted, the device can be reloaded or discarded.

Abstract: A device is disclosed for compounding two solutions contained in cartridges, where one of the cartridges serves as the mixing vessel. The device can be used for buffering anesthetic prior to use by a medical practitioner, including, but not limited to, dentists buffering local anesthetic prior to use. In various embodiments, a container of buffering solution can be incorporated into the device, which will maintain the buffer in a stable condition. The device can be used to buffer anesthetic in one or more cartridges and when the buffer in the device is exhausted, the device can be reloaded or discarded.

Abstract: Anesthetics and other medical solutions are stored in a cartridge including a hollow body having a needle-penetrable septum at one end and a plunger at another end. A protective plug is inserted into the open plunger end of the cartridge and protects the cartridge from contamination per use. A buffer or other material may be injected into the cartridge, causing displacement of the protective plug, allowing the cartridge to then be used in a syringe or other delivery system. The anesthetic may contain at least one solute and have an initial tonicity and an initial pH. A volume of buffer may be injected through the septum into the anesthetic, where the initial solute concentration and initial pH of the anesthetic may be selected to provide a target pH and target tonicity after the buffer is introduced.

Abstract: System for the delivery of drugs from sealed cartridges provide for versatile and convenient delivery of the drugs. The system can be designed to deliver drugs from a plurality of cartridges with delivery through a manifold that connects to the plurality of cartridges. In some embodiments, the system mediates the heating of the drug such that it can be delivered at a temperature more closely approximating body temperature. In some embodiments, the composition of one cartridge is used to adjust the pH of the composition of the resulting mixture to achieve a desirable blended drug. The systems and procedures are particularly advantageous for the delivery of dental anesthetics.

Abstract: Anesthetic is delivered in a substantially continuous manner through a hole drilled in a jaw bone of a dental surgery patient. The hole is drilled in a conventional manner and a fixture embedded in the bone. An adapter is attached to the fixture and anesthetic is delivered substantially continuously through a tube connected to the adapter. An interference fit between the fixture and the adapter provides a liquid seal. The tube may be connected to the fixture by an interference fit, by adhesive or by molding.