Abstract: Provided herein are genetically engineered cells containing one or more modulated metabolic genes, where the expression of the modulated metabolic gene(s) can be greater than that of an unmodified control. Also provided herein are methods of making the genetically engineered cells using synergistic activation mediator CRISPR-Cas9. Further provided herein are high throughput assays that can employ the genetically engineered cells provided herein.

Abstract: Provided herein are genetically engineered cells containing one or more modulated metabolic genes, where the expression of the modulated metabolic gene(s) can be greater than that of an unmodified control. Also provided herein are methods of making the genetically engineered cells using synergistic activation mediator CRISPR-Cas9. Further provided herein are high throughput assays that can employ the genetically engineered cells provided herein.

Abstract: A support device for a cytocentrifuge sample container includes a support body including spaced edge fingers and a clip hinged to the support body. The clip has a latch for each spaced edge finger of the support body and edge members each including lugs engaging slotted ledges in the sample container.

Abstract: A support device for a cytocentrifuge sample container includes a support body including spaced edge fingers and a clip hinged to the support body. The clip has a latch for each spaced edge finger of the support body and edge members each including lugs engaging slotted ledges in the sample container.

Abstract: A novel V crimp roof panel design allowing for the frameless installation of solar panels.

Abstract: Inter-carrier interference (ICI) in a kth sub-carrier of an orthogonal frequency division multiplexing (OFDM) signal received at time t is reduced, wherein the received OFDM signal comprises a plurality of sub-carriers. This is achieved by generating a self-interference term, ICIk?L,k?L, for a signal received on sub-carrier k?L, wherein L ? [ . . . , ?3,?2,?1,1,2,3, . . . ], and wherein the self-interference term is an estimate of the data received at time t on the sub-carrier k?L, weighted by a rate of change of the channel through which sub-carrier k?L passes at time t. An ICI cancellation coefficient, GL is obtained, and an estimated ICI term is generated by adjusting the self-interference term, ICIk?L,k?L, by an amount based on the ICI cancellation coefficient, GL. The estimated ICI term is then subtracted from a term representing a signal received on the kth sub-carrier at time t.

Abstract: A container top having an integral cover, for example, an integral dust cover, is provided. The container top includes a cap having a cylindrical skirt with a top, a bottom, a first outside diameter at the top of the skirt, a second outside diameter at the bottom of the skirt, and an inside surface adapted to engage a container; and a ring mounted to the top of the cylindrical skirt, the ring having an opening; and a cover removably mounted to the cap and occluding the opening in the ring. The container top may include a septum positioned in the opening, for example, a septum that can be pierced with a syringe. The container cap may be used in a wide range of industries, for example, the medical, pharmaceutical, the general scientific community, or in any industry where liquid or gaseous samples are handled.

Abstract: Circuits for reducing the signal peaks in telecommunications signals are described. The circuits and methods are preferably adapted for reducing the peak to average power ratio of non-constant envelope modulation signals. In one example the circuit includes a band-limiting filter for limiting the bandwidth of a data bearing signal and a predictive filter for predicting peaks in the data bearing signal at the output of the pulse-shaping filter. The circuit also includes a clipping processor for generating a compensation signal in response to one or more signal peaks predicted by the predictive filter and a signal combining device for applying the compensation signal to the data bearing signal prior to amplification of the data bearing signal.

Abstract: A method for performing channel estimation in an orthogonal frequency-division multiplexing system, the method including the steps of: receiving (80) transmitting pilot symbols from a plurality of transmit antennas; forming (82) a least-squares estimation matrix from the transmitted pilot symbols; forming (8488) a sparse smoothing matrix approximating a fixed weighting matrix, wherein each row vector in the sparse smoothing matrix contains one or more of the strongest weights in each row of the fixed weighting matrix; and (90) deriving a channel estimation matrix from the sparse smoothing matrix and the least-squares estimation matrix.

Abstract: Inter-carrier interference (ICI) in a kth sub-carrier of an orthogonal frequency division multiplexing (OFDM) signal received at time t is reduced, wherein the received OFDM signal comprises a plurality of sub-carriers. This is achieved by generating a self-interference term, ICIk?L,k?L, for a signal received on sub-carrier k?L, wherein L ? [ . . . , ?3,?2,?1,1,2,3, . . . ], and wherein the self-interference term is an estimate of the data received at time t on the sub-carrier k?L, weighted by a rate of change of the channel through which sub-carrier k?L passes at time t. An ICI cancellation coefficient, GL is obtained, and an estimated ICI term is generated by adjusting the self-interference term, ICIk?L,k?L, by an amount based on the ICI cancellation coefficient, GL. The estimated ICI term is then subtracted from a term representing a signal received on the kth sub-carrier at time t.

Abstract: The present invention relates to an arrangement and a method for amplifying high frequency RF signals having amplitude and phase variations. The objective problem of the present invention is to provide an efficient power amplifier for amplifying high frequency RF signals. The object is achieved by introducing a Signal Conditioning Device (SCD) that converts baseband signals SI and SQ into tri-states signals STI, STQ. The tri-states signals STI, STQ are time multiplexed, which results in that a single power amplifier can be used to amplify the signal on the In-phase (I) channel and the signal on the Quadrature (Q) channel. Hence, the present invention does not require a power combiner.

Abstract: A signal peak reduction circuit (10), comprising: a band-limiting filter (13) for limiting the bandwidth of a data bearing signal, a predictive filter (12) for predicting peaks in the data bearing signal at the output of the pulse-shaping filter, a clipping processor (15) for generating a compensation signal in response to one or more signal peaks predicted by the predictive filter, and a signal combining device (16) for applying the compensation signal to the data bearing signal prior to amplification of the data bearing signal.

Abstract: The present invention relates to an arrangement and a method for amplifying high frequency RF signals having amplitude and phase variations. The objective problem of the present invention is to provide an efficient power amplifier for amplifying high frequency RF signals. The object is achieved by introducing a Signal Conditioning Device (SCD) that converts baseband signals SI and SQ into tri-states signals STI, STQ. The tri-states signals STI, STQ are time multiplexed, which results in that a single power amplifier can be used to amplify the signal on the In-phase (I) channel and the signal on the Quadrature (Q) channel. Hence, the present invention does not require a power combiner.

Abstract: A distortion correction circuit for a direct conversion receiver, the direct conversion receiver comprising a local oscillator for generating a local oscillator signal, a mixer for multiplying a radio frequency signal, and a local oscillator signal together and supplying the resultant mixer output signal to a demodulated signal, the demodulated signal path including a first low-pass filter for selecting a baseband signal at a first filter output terminal, wherein the offset correction circuit includes a squaring circuit for squaring the mixer output signal and supplying the resultant distortion estimate signal to a distortion estimate signal path, signal subtraction means for subtracting the resultant output signal at a subtraction point in the distortion estimate signal path, and adaptive processing means for equalising the transfer function of the distortion signal estimate path and the transfer function of the demodulated signal path between the mixer output and the subtraction point.

Abstract: A collection and transfer device including a collection vessel having an opening on one end and a closure apparatus engageable therewith which has a collection device receivable within the collection vessel, and a passage therethrough for transferring a collected sample from within the collection vessel to a centrifuge or other type of vessel or microscope slide.

Abstract: A tissue grinding system includes a container having an open top portion, a bottom portion having a first grinding surface on an interior surface, and a wall portion interconnecting the top portion and bottom portion defining a hollow interior chamber; a grinder receivable in the top portion of the container and having a second grinding surface engageable with the first grinding surface and including an actuator portion extending beyond the top portion, and a closure device sealingly engaged with the grinder and with the open top portion of the container to seal the chamber.

Abstract: A linearized power amplifier is provided which comprises a non-linear radio frequency (RF) power amplifier, a linearization circuit such as a Cartesian Feedback circuit, an RF feedback circuit; an IF feedback circuit; or a feedforward circuit, and a dynamic bias modulation circuit for modulating an operating voltage of the amplifier. The dynamic bias modulation means includes an envelope determining circuit, signal processing circuits in which predetermined data or a simplified transfer function determined from measured characteristics of the amplifier is stored and used to produce power bias and/or base or gate bias signals, and driver circuits for modulating the power supply voltage and/or base or gate bias voltage of the RF amplifier in response to the bias signals. The dynamic bias modulation may be used with a BJT-based, and FET-based or any other type of RF power amplifier.