Abstract: A fuse system for use with a disposable component of a device may include a disposable component having at least a first lockout circuit and a second lockout circuit. The first lockout circuit may include a first fuse link, and the second lockout circuit may include a second fuse link. The fuse system may include a computing device in communication with the first lockout circuit and the second lockout circuit, and a computer-readable storage medium in communication with the computing device. The computer-readable storage medium may include one or more programming instructions for deactivating the first fuse link at a first time, and deactivating the second fuse link at a second time.

Abstract: A fuse system for a hyperthermia apparatus may include a disposable reservoir cartridge configured to be used with a hyperthermia apparatus. The disposable reservoir cartridge may include at least a first lockout circuit and a second lockout circuit. The first lockout circuit may include a first fuse link, and the second lockout circuit may include a second fuse link. The fuse system may include a computing device in communication with the first lockout circuit and the second lockout circuit, and a computer-readable storage medium in communication with the computing device. The computer-readable storage medium may include one or more programming instructions for deactivating the first fuse link at a first time, and deactivating the second fuse link at a second time.

Abstract: A heating system for a hyperthermia apparatus may include a heater having a plurality of independently controllable heater elements located on one or more surfaces of the heater, and a temperature sensor associated with one or more of the heater elements. Each of the surfaces may be proximate to a reservoir cartridge. The heating system may include a computing device in communication with the temperature sensor. The computing device may be configured to adjust an amount of electrical current to the one or more heater elements associated with the temperature sensor based on a temperature reading received from the temperature sensor.

Abstract: An apparatus for implementing hyperthermia may include a reservoir cartridge having an inlet and an outlet, a disposable outflow tube having a reservoir cartridge end connected to the reservoir cartridge at the outlet and an outflow catheter end connected to an outflow catheter, a disposable inflow tube having a reservoir cartridge end connected to the reservoir cartridge at the inlet and an inflow catheter end connected to an inflow catheter, a pump connected to the outflow tube, an integrated computer in communication with at least one disposable temperature sensor and at least one pressure sensor, a thermoelectric heater, proximate to the reservoir cartridge and a housing that contains the reservoir cartridge, the heater and the integrated computer.

Abstract: A method and device for extracorporeal treatment of a patient by heating the patient's blood and/or a regional anatomic area which utilizes an optional hemodialysis machine capable of heating the fluids to 48° C., an optional parallel plate dialyzer together with a sorbent-based detoxifier, a tubular heat exchanger and a high flow positive displacement puma-in addition to various probes and catheters. The present invention also includes a disposable tubing set for directing fluids used in extracorporeal hyperthermia procedures. The tubing set contains a fluid reservoir, accommodates the positive displacement pump, and includes a heat exchanger for heating blood or fluid. The specific improvements in extracorporeal heating afforded by this system inhere in the combined high flow of the pump and the high temperature—up to 52° C.

Abstract: An apparatus and system for extracorporeal treatment utilizes a hemodialysis machine capable of heating dialysis fluid to 48° C., an optional parallel plate hemodialyzer together with a sorbent-based detoxifier, a tubular heat exchanger and a high flow pump—in addition to various probes and catheters—to effect extracorporeal treatment without adverse physiological effect and without the specific need for general anesthesia. The system inheres in the combined high flow of the pump-up to 2400 ml per minute—and the high temperature—52° C.—achievable in the heat exchanger, which together provide unprecedented speed and efficiency in the administration of hyperthemia treatments. The system is also a potentiating system in the administration of heat sensitive pharmaceutically active agents and is praticularly useful in the isolated anatomic areas of a patient.