Patents by Inventor Michael Feld
Michael Feld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230388662Abstract: A pixel array of an image sensor includes a plurality of color filter array (CFA) cells. Each of the plurality of CFA cells includes first, second, third, and fourth CFA blocks. Each of the first and second CFA blocks includes a plurality of pixels to sense light of a first color. Most pixels of the third CFA block are configured to sense the second color and the third CFA block includes at least one first pixel to sense the first light. Most pixels of the fourth CFA block are configured to sense a third color of light and the fourth CFA block includes at least one second green pixel to sense the first light.Type: ApplicationFiled: May 24, 2022Publication date: November 30, 2023Inventors: Tal Michael Feld, Gai Bitan, Igal Avishai
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Patent number: 10780555Abstract: The invention relates to a combination (1) of control cabinet keys (2), individual keys being situated in the same plane but extending at a fixed angle (x) relative to one another and connected via a common center part (4, 5). Due to the fixed connection between the keys, during handling, a torque may be applied to a key (2) that is used. For ease of handling, a first unit (E1) and a second unit (E2) of keys extending at a fixed angle (x) relative to one another are provided, all units (E1, E2) have their own center part, and the units are detachably connected at their center parts (4, 5), and/or the keys are rotatable relative to one another, but only in a respective predefined plane.Type: GrantFiled: February 17, 2011Date of Patent: September 22, 2020Assignee: KNIPEX-Werk C. Gustav Putsch KGInventors: Ralf Putsch, Michael Feld, Filip Marovic
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Patent number: 10451402Abstract: The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.Type: GrantFiled: January 25, 2012Date of Patent: October 22, 2019Assignees: Massachusetts Institute of Technology, Hamamatsu Photonics K.K.Inventors: Zahid Yaqoob, Wonshik Choi, Toyohiko Yamauchi, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Patent number: 10256262Abstract: Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.Type: GrantFiled: June 10, 2014Date of Patent: April 9, 2019Assignees: Massachusetts Institute of Technology, Hamamatsu Photonics K.K.Inventors: Gabriel Popescu, Ramachandra Dasari, Michael Feld, Takahiro Ikeda
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Publication number: 20170281059Abstract: The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.Type: ApplicationFiled: July 15, 2015Publication date: October 5, 2017Inventors: Kate Bechtel, Wei-Chuan Shih, Michael Feld
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Publication number: 20170202462Abstract: The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers.Type: ApplicationFiled: December 22, 2016Publication date: July 20, 2017Inventors: Jason Motz, Luis H. Galindo, Martin Hunter, Abigail S. Haka, Saumil Gandhi, Ramachandra Dasari, Michael Feld
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Patent number: 9662047Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.Type: GrantFiled: June 23, 2011Date of Patent: May 30, 2017Assignee: Massachusetts Institute of TechnologyInventors: Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, Michael Feld, Jonathan Feld, David Feld, Alison Hearn, Chae-Ryon Kong, Jeon Woong Kang
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Patent number: 9546952Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.Type: GrantFiled: September 18, 2014Date of Patent: January 17, 2017Assignee: Massachusetts Institute of TechnologyInventors: Wonshik Choi, Ramachandra Dasari, Christopher Fang-Yen, Michael Feld
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Patent number: 9528817Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement of biological materials which can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering.Type: GrantFiled: December 14, 2012Date of Patent: December 27, 2016Assignee: Massachusetts Institute of TechnologyInventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
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Patent number: 9433351Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.Type: GrantFiled: May 4, 2012Date of Patent: September 6, 2016Assignee: Massachusetts Institute of TechnologyInventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20160100777Abstract: The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.Type: ApplicationFiled: July 15, 2015Publication date: April 14, 2016Inventors: Kate Bechtel, Wei-Chuan Shih, Michael Feld
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Publication number: 20130014616Abstract: The invention relates to a combination (1) of control cabinet keys (2), individual keys being situated in the same plane but extending at a fixed angle (x) relative to one another and connected via a common center part (4, 5). Due to the fixed connection between the keys, during handling, a torque may be applied to a key (2) that is used.Type: ApplicationFiled: February 17, 2011Publication date: January 17, 2013Applicant: KNIPEX-WERK C. GUSTAV PUTSCH KGInventors: Ralf Putsch, Michael Feld, Filip Marovic
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Patent number: 8355767Abstract: The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.Type: GrantFiled: April 27, 2006Date of Patent: January 15, 2013Assignee: Massachusetts Institute of TechnologyInventors: Martin Hunter, Annika Enejder, Thomas Scecina, Michael Feld, Wei-Chuan Shih
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Patent number: 8334982Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.Type: GrantFiled: June 30, 2009Date of Patent: December 18, 2012Assignee: Massachusetts Institute of TechnologyInventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
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Publication number: 20120307035Abstract: The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.Type: ApplicationFiled: January 25, 2012Publication date: December 6, 2012Inventors: Zahid Yaqoob, Wonshik Choi, Toyohiko Yamauchi, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20120302892Abstract: A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.Type: ApplicationFiled: December 28, 2011Publication date: November 29, 2012Inventors: Niyom Lue, Michael Feld, Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20120259228Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.Type: ApplicationFiled: May 4, 2012Publication date: October 11, 2012Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20120035442Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.Type: ApplicationFiled: June 23, 2011Publication date: February 9, 2012Inventors: Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, Michael Feld, Chae-Ryon Kong, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20100249607Abstract: The present invention relates to a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a powerful surveillance tool for objective early cancer detection. The design, construction, calibration, and diagnostics applications of this system is described with the use of physical tissue models. Measurements were conducted on a resected colon adenoma, and the system can be used for vivo imaging in the oral cavity.Type: ApplicationFiled: September 28, 2009Publication date: September 30, 2010Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Chung-Chieh Yu, Condon Lau, Ramachandra Dasari, Michael Feld
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Publication number: 20100069720Abstract: The present invention provides systems and methods for the spectroscopic determination of the physical characteristics of the tissue under observation by an autofluorescence or other endoscope without the requirement of contacting the tissue directly. The optical probe contained in the endoscope itself is passive and may be either built into the endoscope or positioned in a biopsy channel of same. The spectroscopic information, combined with other information provided by the endoscope such as total fluorescence, improves the sensitivity and specificity of the identification of precancerous or cancerous lesions.Type: ApplicationFiled: November 30, 2007Publication date: March 18, 2010Applicant: NEWTON LABORATORIES, INC.Inventors: Stephen Fulghum, Charles Von Rosenberg, Michael Feld