Patents by Inventor Michael Finnin

Michael Finnin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal structure of a deacetylase and inhibitors thereof
    Publication number: 20070100559
    Abstract: The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.
    Type: Application
    Filed: August 16, 2006
    Publication date: May 3, 2007
    Inventors: Nikola Pavletich, Michael Finnin, Jill Donigian, Victoria Richon, Richard Rifkind, Paul Marks, Ronald Breslow
  • Crystal structure of a deacetylase and inhibitors thereof
    Publication number: 20070087427
    Abstract: The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.
    Type: Application
    Filed: August 16, 2006
    Publication date: April 19, 2007
    Inventors: Nikola Pavletich, Michael Finnin, Jill Donigian, Victoria Richon, Richard Rifkind, Paul Marks, Ronald Breslow
  • Crystal structure of a deacetylase and inhibitors thereof
    Patent number: 7124068
    Abstract: The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: October 17, 2006
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Nikola Pavletich, Michael Finnin, Jill Donigian, Victoria M. Richon, Richard A. Rifkind, Paul A. Marks, Ronald Breslow
  • Crystal structure of a deacetylase and inhibitors thereof
    Publication number: 20030013176
    Abstract: The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.
    Type: Application
    Filed: March 8, 2002
    Publication date: January 16, 2003
    Inventors: Nikola Pavletich, Michael Finnin, Jill Donigian, Victoria M. Richon, Richard A. Rifkind, Paul A. Marks, Ronald Breslow