Patents by Inventor Michael Fischbach

Michael Fischbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12257235
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Grant
    Filed: December 12, 2023
    Date of Patent: March 25, 2025
    Assignees: Mayo Foundation for Medical Education and Research, The Regents of the University of California
    Inventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams
  • Patent number: 12103946
    Abstract: Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R1, R2, R3a, R3b, R4a, R4b, R5, R6a, R6b, R7, R8, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for promoting differentiation of T regulatory (Treg) lymphocytes, and for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, and graft-versus-host disease.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: October 1, 2024
    Assignee: New York University
    Inventors: Dan R. Littman, Jun R. Huh, Michael Fischbach
  • Publication number: 20240261264
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Application
    Filed: December 12, 2023
    Publication date: August 8, 2024
    Inventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams
  • Patent number: 11878002
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: January 23, 2024
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of California
    Inventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams
  • Publication number: 20220362268
    Abstract: The present application relates to methods for treatment of bacteria and viruses with C2-C7 alkyl boronic acids to reduce growth and virulence.
    Type: Application
    Filed: October 7, 2020
    Publication date: November 17, 2022
    Inventors: Kenneth W. SIMPSON, Shiying ZHANG, Michael FISCHBACH
  • Publication number: 20220062235
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Application
    Filed: April 8, 2021
    Publication date: March 3, 2022
    Inventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams
  • Publication number: 20210347811
    Abstract: Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R1, R2, R3a, R3b, R4a, R4b, R5, R6a, R6b, R7, R8, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for promoting differentiation of T regulatory (Treg) lymphocytes, and for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, and graft-versus-host disease.
    Type: Application
    Filed: October 8, 2019
    Publication date: November 11, 2021
    Inventors: Dan R. LITTMAN, Jun R. HUH, Michael FISCHBACH
  • Patent number: 10993930
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: May 4, 2021
    Assignees: Mayo Foundation for Medical Education and Research, The Regents of the University of California
    Inventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams
  • Publication number: 20190358200
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Application
    Filed: April 18, 2019
    Publication date: November 28, 2019
    Inventors: Purna C. Kashyap, Michael Fischbach
  • Patent number: 10300043
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: May 28, 2019
    Assignees: Mayo Foundation for Medical Education and Research, The Regents of the University of California
    Inventors: Purna C. Kashyap, Michael Fischbach
  • Publication number: 20170042860
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Application
    Filed: August 12, 2016
    Publication date: February 16, 2017
    Inventors: Purna C. Kashyap, Michael Fischbach
  • Publication number: 20060280029
    Abstract: The present invention relates generally to microfluidic systems and, more specifically, to apparatuses and methods associated with mixing in microfluidic systems. In some embodiments, a mixer is constructed and arranged to mix at least a portion of a first and a second fluid component. The mixer may include a channel having an inlet that separates into at least two branches, the branches then recombining into a single outlet. In some cases, plugs of fluid (e.g., a gas) are flowed into the branches, which causes changes in resistance, and thus the amount of fluid flow, in each of the branches. The motion of the plugs through the network of branched channels can create unsteady mixing flows. For instance, for two fluid components, e.g., two streams of fluid flowing laminarly in the channel, these changes in resistance can cause the crossing of laminar streamlines of the fluid, which can lead to exponential stretching and folding of the interface between the two unmixed streams.
    Type: Application
    Filed: June 13, 2005
    Publication date: December 14, 2006
    Applicant: President and Fellows of Harvard College
    Inventors: Piotr Garstecki, Michael Fischbach, George Whitesides