Abstract: A lock nut is useable for setting a bearing to preload or endplay. A plurality of preload markings are circumferentially spaced apart on the nut. The distance between the preload marking corresponding to a preselected amount of preload applied or reduced on said bearing when the nut is (i) tightened to apply a preload force to said bearing or (ii) loosened to reduce a preload force on said bearing, respectively. A plurality of endplay markings are also circumferentially spaced apart on the nut. The distance between the endplay markings, corresponding to a preselected amount of endplay increased or reduced in said bearing when the nut is (i) tightened to reduce endplay on the bearing or (ii) loosened to increase endplay in said bearing. The use of endplay and preload markings enables setting of a bearing on an axle or spindle to either an endplay setting or a preload setting by adjusting the rotation of the lock nut according to the endplay markings or the preload markings, respectively.

Abstract: A lock nut is useable for setting a bearing to preload or endplay. A plurality of preload markings are circumferentially spaced apart on the nut. The distance between the preload marking corresponding to a preselected amount of preload applied or reduced on said bearing when the nut is (i) tightened to apply a preload force to said bearing or (ii) loosened to reduce a preload force on said bearing, respectively. A plurality of endplay markings are also circumferentially spaced apart on the nut. The distance between the endplay markings, corresponding to a preselected amount of endplay increased or reduced in said bearing when the nut is (i) tightened to reduce endplay on the bearing or (ii) loosened to increase endplay in said bearing. The use of endplay and preload markings enables setting of a bearing on an axle or spindle to either an endplay setting or a preload setting by adjusting the rotation of the lock nut according to the endplay markings or the preload markings, respectively.

Abstract: A lock nut is useable for setting a bearing to preload or endplay. A plurality of preload markings are circumferentially spaced apart on the nut. The distance between the preload marking corresponding to a preselected amount of preload applied or reduced on said bearing when the nut is (i) tightened to apply a preload force to said bearing or (ii) loosened to reduce a preload force on said bearing, respectively. A plurality of endplay markings are also circumferentially spaced apart on the nut. The distance between the endplay markings, corresponding to a preselected amount of endplay increased or reduced in said bearing when the nut is (i) tightened to reduce endplay on the bearing or (ii) loosened to increase endplay in said bearing. The use of endplay and preload markings enables setting of a bearing on an axle or spindle to either an endplay setting or a preload setting by adjusting the rotation of the lock nut according to the endplay markings or the preload markings, respectively.

Abstract: A lock nut is useable for setting a bearing to preload or endplay. A plurality of preload markings are circumferentially spaced apart on the nut. The distance between the preload marking corresponding to a preselected amount of preload applied or reduced on said bearing when the nut is (i) tightened to apply a preload force to said bearing or (ii) loosened to reduce a preload force on said bearing, respectively. A plurality of endplay markings are also circumferentially spaced apart on the nut. The distance between the endplay markings, corresponding to a preselected amount of endplay increased or reduced in said bearing when the nut is (i) tightened to reduce endplay on the bearing or (ii) loosened to increase endplay in said bearing. The use of endplay and preload markings enables setting of a bearing on an axle or spindle to either an endplay setting or a preload setting by adjusting the rotation of the lock nut according to the endplay markings or the preload markings, respectively.

Abstract: Media content containing a substantially invisible watermark and/or a fingerprint may be redistributed/retransmitted in a way that bypasses bypass the detectability of a hidden or invisible watermark or fingerprint. In particular, a first segment of media content may be received by a first receiver and a second segment of media content may be received by a second server. The first and second segments may be stored on a storage device. The first and second segments may be made available to a client in the form of a concatenated media content.

Abstract: An electrophysiology catheter includes an elongate catheter body having an elastically-deformable distal region predisposed to assume a spiral shape and a first plurality of electrodes disposed thereon. Each of the first plurality of electrodes includes an electrically active region limited to the inner surface of the spiral shape for use in non-contact electrophysiology studies. A second plurality of electrodes may also be disposed on the distal region interspersed (e.g., alternating) with the first plurality of electrodes, with each of the second plurality of electrodes having an electrically active region extending into the outer surface of the spiral shape for use in contact electrophysiology studies. The distal region may be deformed into a straight configuration for insertion into and navigation through the patient's vasculature, for example via use of a tubular introducer. As the distal region deploys beyond the distal end of the introducer, it resumes the spiral shape.

Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.

Abstract: The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of Formula I, an 19F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N?,N?,N??-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.

Abstract: The present invention relates to a method of in vivo optical imaging, of the margins around tumours, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of near-infrared dyes with synthetic polyethylene glycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are optical imaging contrast agents, pharmaceutical compositions and kits.

Abstract: The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site.

Abstract: The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site.

Abstract: The present invention provides compositions derived from a polycarboxylic acid, a polyhydroxy compound, a dye and a basic crosslinking agent. The compositions can be used to prepare cross-linked films that exhibit low solvent-swell characteristics. The cross-linked films can be used to prepare color filter elements via thermal transfer processes.

Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein.

Abstract: Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.

Abstract: The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of Formula I, an 19F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N?,N?,N??-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.

Abstract: Provided herein are amyloid-binding assays that simulate in situ brain conditions by combining binders with various A-beta species on mammalian brain tissue. In general the amyloid-binding assays comprise the steps of (a) contacting a mammalian brain tissue sample with at least one A-beta species; (b) applying a putative binder to the brain tissue sample; and (c) determining whether the putative binder binds to the A-beta species.

Abstract: In one aspect, the present invention provides a functionalized monodisperse polylysine comprising a linear monodisperse polylysine chain comprising constituent lysine monomer residues containing appended C4-C24 polyethylene glycol groups and at least one appended fluorescent dye moiety is provided.