Patents by Inventor Michael Fitzpatrick Wempe

Michael Fitzpatrick Wempe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 11964985
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: April 23, 2024
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 11472812
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: October 18, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Chao Yan, Phillip Reigan
  • N-SUBSTITUTED-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME
    Publication number: 20210309618
    Abstract: The present invention relates to the discovery of novel N-(substituted)-1H-1,2,4-triazole-3-carboxamide compounds capable of inhibiting DksA activity in a bacteria cell. In certain embodiments, the compounds are capable of killing or weakening bacteria. In another aspect, the invention relates to methods of treating bacterial infection in a subject in need thereof, the method comprising administering to the subject a compound of the invention.
    Type: Application
    Filed: August 22, 2019
    Publication date: October 7, 2021
    Inventors: Michael Fitzpatrick WEMPE, Andres VAZQUEZ-TORRES, Shaodong DAI
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20200270263
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 27, 2020
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Dan THEODORESCU, Michael Fitzpatrick WEMPE, David ROSS, Samy MEROUEH, Martin A. SCHWARTZ, Phillip REIGAN
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20200255442
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Application
    Filed: April 30, 2020
    Publication date: August 13, 2020
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Dan THEODORESCU, Michael Fitzpatrick WEMPE, David ROSS, Chao YAN, Phillip REIGAN
  • Anti-cancer compounds targeting ral GTPases and methods of using the same
    Patent number: 10689392
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: June 23, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 10676480
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: June 9, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Chao Yan, Phillip Reigan
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20190135824
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 9, 2019
    Inventors: Dan THEODORESCU, Michael Fitzpatrick WEMPE, David ROSS, Chao YAN, Phillip REIGAN
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 10202397
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: February 12, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Chao Yan, Phillip Reigan
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20170204112
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Application
    Filed: July 10, 2015
    Publication date: July 20, 2017
    Inventors: Dan THEODORESCU, Michael Fitzpatrick WEMPE, David ROSS, Chao YAN, Phillip REIGAN
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20160280715
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Application
    Filed: April 29, 2016
    Publication date: September 29, 2016
    Inventors: Dan THEODORESCU, Michael Fitzpatrick WEMPE, David ROSS, Samy MEROUEH, Martin A. SCHWARTZ, Phillip REIGAN
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 9353121
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 31, 2016
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20140315894
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Application
    Filed: December 21, 2012
    Publication date: October 23, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF
    Publication number: 20120302638
    Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
    Type: Application
    Filed: August 8, 2012
    Publication date: November 29, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Michael Fitzpatrick Wempe, Liu Deng, Stephanie Kay Clendennen, Neil Warren Boaz
  • Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
    Patent number: 8263094
    Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: September 11, 2012
    Assignee: Eastman Chemical Company
    Inventors: Michael Fitzpatrick Wempe, Liu Deng, Stephanie Kay Clendennen, Neil Warren Boaz
  • 5-hydroxy-2-methyl-4H-pyran-4-one esters as novel tyrosinase inhibitors
    Patent number: 8183398
    Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: May 22, 2012
    Assignee: Eastman Chemical Company
    Inventors: Michael Fitzpatrick Wempe, Jeffrey Michael Clauson, Liu Deng
  • 5-Hydroxy-2-Methyl-4H-Pyran-4-One Esters as Novel Tyrosinase Inhibitors
    Publication number: 20100216873
    Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
    Type: Application
    Filed: April 7, 2010
    Publication date: August 26, 2010
    Applicant: Eastman Chemical Company
    Inventors: Michael Fitzpatrick Wempe, Jeffrey Michael Clauson, Liu Deng
  • ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF
    Publication number: 20100076077
    Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
    Type: Application
    Filed: September 23, 2008
    Publication date: March 25, 2010
    Applicant: Eastman Chemical Company
    Inventors: Michael Fitzpatrick Wempe, Liu Deng, Stephanie Kay Clendennen, Neil Warren Boaz
  • 5-HYDROXY-2-METHYL-4H-PYRAN-4-ONE ESTERS AS NOVEL TYROSINASE INHIBITORS
    Publication number: 20090215887
    Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
    Type: Application
    Filed: February 25, 2008
    Publication date: August 27, 2009
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Michael Fitzpatrick Wempe, Jeffrey Michael Clauson
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: RE48557
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: May 18, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Chao Yan, Phillip Reigan