Abstract: In one aspect, the invention relates to a crystalline form of the structure: or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crystalline form; methods of using this crystalline form and its soluble form (I); and processes for preparing soluble (I) and crystalline (I?) forms.

Abstract: The present disclosure describes methods of treatment of cancer in patients with altered activity or amount of a SETD2 biomarker with a treatment regimen comprising an antagonist of Programmed Death 1 receptor (PD-1).

Abstract: A system for purging air from a feeding line is set forth. The system includes a charging device configured to selectively provide an air charge in the system. A restricting tubing can be located between the charging device and a delivery tube. The restricting tubing can be configured to tunably limit the air charge delivered from the charging device to the feeding line through the delivery tube.

Abstract: A heating system for warming nutritional liquid fed to a neonate or preterm infant may comprise a control module and a heater. The heating system is portable so that the heating system is not connected to a syringe pump or other device used to feed the neonate. The heater of the heating system is mounted to the tube that is used to feed the neonate. The heater is positioned along the tube in close proximity to the neonate so that a temperature drop of the nutritional liquid after the nutritional liquid exits the heater and reaches the neonate is negligible. The heater raises the temperature of the nutritional liquid to a target desired temperature (e.g., body temperature of the mother and neonate or to a temperature above the temperature of the mother and neonate) so that the neonate may consume warm nutritional fluid. Once the nutritional liquid reaches the neonate, the nutritional liquid is at about the body temperature of the mother or neonate or at least above room temperature.

Abstract: A heating system for warming nutritional liquid fed to a neonate or preterm infant may comprise a control module and a heater. The heating system is portable so that the heating system is not connected to a syringe pump or other device used to feed the neonate. The heater of the heating system is mounted to the tube that is used to feed the neonate. The heater is positioned along the tube in close proximity to the neonate so that a temperature drop of the nutritional liquid after the nutritional liquid exits the heater and reaches the neonate is negligible. The heater raises the temperature of the nutritional liquid to a target desired temperature (e.g., body temperature of the mother and neonate or to a temperature above the temperature of the mother and neonate) so that the neonate may consume warm nutritional fluid. Once the nutritional liquid reaches the neonate, the nutritional liquid is at about the body temperature of the mother or neonate or at least above room temperature.

Abstract: A heating system for warming nutritional liquid fed to a neonate or preterm infant may comprise a control module and a heater. The heating system is portable so that the heating system is not connected to a syringe pump or other device used to feed the neonate. The heater of the heating system is mounted to the tube that is used to feed the neonate. The heater is positioned along the tube in close proximity to the neonate so that a temperature drop of the nutritional liquid after the nutritional liquid exits the heater and reaches the neonate is negligible. The heater raises the temperature of the nutritional liquid to a target desired temperature (e.g., body temperature of the mother and neonate or to a temperature above the temperature of the mother and neonate) so that the neonate may consume warm nutritional fluid. Once the nutritional liquid reaches the neonate, the nutritional liquid is at about the body temperature of the mother or neonate or at least above room temperature.

Abstract: A variable flow rate controller is provided herein. The controller may have a linearly traversable switch such that the controller is primed to flush air bubbles out of the fluid system of the controller prior to administering fluidic medication to a patient. Moreover, the controller may have a plurality of valves which may be independently opened and closed by a caming surface. To close the valve, a first seal may be disposed between offset inlet and outlet to prevent fluid from flowing from the inlet to the outlet. To open the valve, the first seal is disposed on one side of both of the inlet and outlet. Fluid if permitted to flow from the inlet to the outlet.

Abstract: A heating system for warming nutritional liquid fed to a neonate or preterm infant may comprise a control module and a heater. The heating system is portable so that the heating system is not connected to a syringe pump or other device used to feed the neonate. The heater of the heating system is mounted to the tube that is used to feed the neonate. The heater is positioned along the tube in close proximity to the neonate so that a temperature drop of the nutritional liquid after the nutritional liquid exits the heater and reaches the neonate is negligible. The heater raises the temperature of the nutritional liquid to a target desired temperature (e.g., body temperature of the mother and neonate or to a temperature above the temperature of the mother and neonate) so that the neonate may consume warm nutritional fluid. Once the nutritional liquid reaches the neonate, the nutritional liquid is at about the body temperature of the mother or neonate or at least above room temperature.

Abstract: A variable flow rate controller is provided herein. The controller may have a linearly traversable switch such that the controller is primed to flush air bubbles out of the fluid system of the controller prior to administering fluidic medication to a patient. Moreover, the controller may have a plurality of valves which may be independently opened and closed by a caming surface. To close the valve, a first seal may be disposed between offset inlet and outlet to prevent fluid from flowing from the inlet to the outlet. To open the valve, the first seal is disposed on one side of both of the inlet and outlet. Fluid if permitted to flow from the inlet to the outlet.

Abstract: A variable flow rate controller is provided herein. The controller may have a linearly traversable switch such that the controller is primed to flush air bubbles out of the fluid system of the controller prior to administering fluidic medication to a patient. Moreover, the controller may have a plurality of valves which may be independently opened and closed by a caming surface. To close the valve, a first seal may be disposed between offset inlet and outlet to prevent fluid from flowing from the inlet to the outlet. To open the valve, the first seal is disposed on one side of both of the inlet and outlet. Fluid if permitted to flow from the inlet to the outlet.

Abstract: A variable flow rate controller is provided herein. The controller may have a linearly traversable switch such that the controller is primed to flush air bubbles out of the fluid system of the controller prior to administering fluidic medication to a patient. Moreover, the controller may have a plurality of valves which may be independently opened and closed by a caming surface. To close the valve, a first seal may be disposed between offset inlet and outlet to prevent fluid from flowing from the inlet to the outlet. To open the valve, the first seal is disposed on one side of both of the inlet and outlet. Fluid if permitted to flow from the inlet to the outlet.

Abstract: A safety needle device is provided for protecting a user against needle-stick injuries. This needle device includes a needle housing having a distal housing opening. A needle is disposed within the needle housing and has a distal needle portion which extends away therefrom through the distal housing opening. An elongate sheath assembly surrounds the needle within the needle housing. A biasing member is engaged to the sheath assembly and is configured to apply a force thereupon towards the distal housing opening. The biasing member defines a centerline which is parallel to the needle's distal needle portion. An indexer is engaged to the biasing member and is operative to increase or decrease a spring force of the biasing member by rotating the indexer. A trigger member is engaged to the biasing member for retaining the sheath assembly within the needle housing against the force urging the sheath assembly towards the distal housing opening.

Abstract: A safety needle device is provided for protecting a user against needle-stick injuries. This needle device includes a needle housing having a distal housing opening. A needle is disposed within the needle housing and has a distal needle portion which extends away therefrom through the distal housing opening. An elongate sheath assembly surrounds the needle within the needle housing. A biasing member is engaged to the sheath assembly and is configured to apply a force thereupon towards the distal housing opening. The biasing member defines a centerline which is parallel to the needle's distal needle portion. An indexer is engaged to the biasing member and is operative to increase or decrease a spring force of the biasing member by rotating the indexer. A trigger member is engaged to the biasing member for retaining the sheath assembly within the needle housing against the force urging the sheath assembly towards the distal housing opening.