Abstract: The present invention discloses compounds of the general formula (Ia) or (Ib): pharmaceutical compositions comprising said compounds and their use in the treatment of diseases, particularly cancers. In addition, method for treating a disease in which mediation, such as inhibition, regulation and/or modulation, of ATM kinase is beneficial in a human or a warm-blooded or mammal animal in need of such treatment is disclosed.

Abstract: The present invention relates to imidazo[4,5-c]quinoline compounds and to their use in the inhibition, regulation and/or modulation of signal transduction by ATM kinase and, in particular, for the treatment of ATM mediated diseases, especially cancer.

Abstract: An arrangement for compensating disturbance voltages induced in a transformer is disclosed. In an embodiment an arrangement includes a transformer component comprising a transformer winding and an ancillary apparatus, wherein the ancillary apparatus comprises an auxiliary winding, wherein the auxiliary winding is connected in series with the transformer winding, and wherein the ancillary apparatus is arranged and designed such that an interference voltage induced in the transformer component is reduced by a counter-voltage induced in the ancillary apparatus.

Abstract: A power tool/battery pack combination includes an electric motor, one or more electrochemical cells, and a capacitive element. The electric motor is connected in series to a first switch. The series combination of the electric motor and the first switch is connected to a first terminal and a second terminal. The one or more electrochemical cells are connected across a third terminal and a fourth terminal. The third terminal and the fourth terminal are coupled respectively to the first terminal and the second terminal. The one or more electrochemical cells supply power to the electric motor via the first switch. The capacitive element includes one or more capacitors. The capacitive element is connected across the third terminal and the fourth terminal. The capacitive element is capable of storing inductive energy generated by the one or more electrochemical cells.

Abstract: A power tool/battery pack combination includes an electric motor, one or more electrochemical cells, and a capacitive element. The electric motor is connected in series to a first switch. The series combination of the electric motor and the first switch is connected to a first terminal and a second terminal. The one or more electrochemical cells are connected across a third terminal and a fourth terminal. The third terminal and the fourth terminal are coupled respectively to the first terminal and the second terminal. The one or more electrochemical cells supply power to the electric motor via the first switch. The capacitive element includes one or more capacitors. The capacitive element is connected across the third terminal and the fourth terminal. The capacitive element is capable of storing inductive energy generated by the one or more electrochemical cells.

Abstract: An arrangement for compensating disturbance voltages induced in a transformer is disclosed. In an embodiment an arrangement includes a transformer component comprising a transformer winding and an ancillary apparatus, wherein the ancillary apparatus comprises an auxiliary winding, wherein the auxiliary winding is connected in series with the transformer winding, and wherein the ancillary apparatus is arranged and designed such that an interference voltage induced in the transformer component is reduced by a counter-voltage induced in the ancillary apparatus.

Abstract: An electrical transformer component includes a central limb having a first and a second end section and a central section, which is arranged between the first and second end sections. The component also includes an outer limb having a holding device for holding the central limb on the outer limb. At least one of the first and second end sections of the central limb is held on the holding device of the outer limb. At least two wires are wound directly onto part of the surface of the central section of the central limb.

Abstract: A power tool/battery pack combination includes an electric motor, one or more electrochemical cells, and a capacitive element. The electric motor is connected in series to a first switch. The series combination of the electric motor and the first switch is connected to a first terminal and a second terminal. The one or more electrochemical cells are connected across a third terminal and a fourth terminal. The third terminal and the fourth terminal are coupled respectively to the first terminal and the second terminal. The one or more electrochemical cells supply power to the electric motor via the first switch. The capacitive element includes one or more capacitors. The capacitive element is connected across the third terminal and the fourth terminal. The capacitive element is capable of storing inductive energy generated by the one or more electrochemical cells.

Abstract: Methods, systems, and computer-readable media for determining whether dependencies of configuration files have changed such that the compilation strategy should be recomputed. Local build checksums are computed for individual configuration files. The local build checksums are computed by sorting input paths to the configuration files plus data indicating whether the path refers to a file or a directory and a checksum computed on the configuration file itself. The transitive closure of local build checksums are then used to compute a global build checksum: the local build checksums are sorted in order to compute the global build checksum. If the global build checksum is different from a previously computed global build checksum, then the compilation strategy should be recomputed, since this is a signal that the compilation strategy may not be valid anymore, e.g. because some dependencies in the configuration files have changed.

Abstract: A build system and method, including receiving attribute rules and new rules, wherein the attribute rules correspond to one or more predefined default actions of the build system, wherein the new rules specify new actions that are to be added to the build system. A graph is generated to include files specified as attributes in the attributes rules and the one or more predefined default actions that correspond to the attributes rules. A request to enable at least one of the new rules is received. Action listener rules are received, wherein the action listener rules indicate default actions and corresponding new rules of the one or more new rules. The graph is checked for default actions that are indicated in the action listener rules. Additional actions are added to the graph for new rules based on the default actions indicated in the action listener rules.

Abstract: A method is disclosed for validation of single nucleotide variants (SNV) in a sequence of interest. In at least one embodiment, the method includes: interrogating a BAM-file of the sequence of interest and a reference sequence file and producing a summary table for genomic coordinates of interest; generating a plurality of sequence reads from a sample of said sequence of interest; filtering sequence reads using a plurality of filter levels; extracting SNV counts for each strand for a genomic region of interest within the sequence of interest, resulting in ten SNV counts; for each genomic region of interest determining a rule based genotype decision and inferring a best genotype from the 10 counts; and creating a single consensus file for said sequence of interest including information of best genotype and a best quality for each genomic region of interest.

Abstract: A power tool for operating on a workpiece, the power tool having a housing and a motor disposed within the housing. A controller is connected to the motor and receives user inputs for turning on the motor and a power tool battery pack is connected to the controller and the motor. At least one light is connected to the controller for illuminating the workpiece. The controller can turn on the light in a predetermined pattern to alert the user to a tool condition, such as the charge level being below a predetermined level.

Abstract: Methods, systems, and computer-readable media for determining whether dependencies of configuration files have changed such that the compilation strategy should be recomputed. Local build checksums are computed for individual configuration files. The local build checksums are computed by sorting input paths to the configuration files plus data indicating whether the path refers to a file or a directory and a checksum computed on the configuration file itself. The transitive closure of local build checksums are then used to compute a global build checksum: the local build checksums are sorted in order to compute the global build checksum. If the global build checksum is different from a previously computed global build checksum, then the compilation strategy should be recomputed, since this is a signal that the compilation strategy may not be valid anymore, e.g. because some dependencies in the configuration files have changed.

Abstract: A method for operating a driving tool, such as a fastening tool, that has a driver, a motor assembly with a motor and an output member, and an electrical power source. The methodology includes transmitting electrical power to the motor to rotate the output member and thereafter adjusting one or more control parameters if a rotational speed of the output member is not within a predetermined operating range.

Abstract: A driving tool having a driver, a power source, a sensor and a controller. The power source selectively provides an input to the driver to cause the driver to translate along an axis. The sensor senses a condition in the power source that is indicative of a level of kinetic energy of an element in the power source and generates a sensor signal in response thereto. The controller is coupled to the power source and the sensor and is responsive to the sensor signal for deactivating the power source to inhibit the power source from providing the input to the driver when the level of kinetic energy of the element in the power source is below a predetermined threshold. A method for operating a driving tool is also provided.

Abstract: A power tool for operating on a workpiece, the power tool having a housing and a motor disposed within the housing. A controller is connected to the motor and receives user inputs for turning on the motor and a power tool battery pack is connected to the controller and the motor. At least one light is connected to the controller for illuminating the workpiece. The controller can turn on the light in a predetermined pattern to alert the user to a tool condition, such as the charge level being below a predetermined level.

Abstract: A cleaning device for cleaning lubricating oil which circulates in a lubricating oil circuit has an intake to be connected with the lubricating oil circuit, through which a part quantity of the lubricating oil circulating in the lubricating oil circuit is to be fed to the cleaning and a return to be connected with the lubricating oil circuit for the returning of the cleaned lubricating oil into the lubricating oil circuit.

Abstract: The present invention provides pharmaceutical compositions which include (?)-pseudoephedrine and a pharmaceutically acceptable carrier, wherein the (?)-pseudoephedrine is substantially-free of (+)-pseudoephedrine. In another embodiment, the present invention provides methods of relieving nasal and bronchial congestion and of inducing pupil dilation which include administering a pharmaceutically effective amount of (?)-pseudoephedrine to a mammal. The (?)-pseudoephedrine used in the present methods is substantially free of (+)-pseudoephedrine and also substantially free of side effects caused by administration of (+)-pseudoephedrine.

Abstract: A gaming method is disclosed and comprises the following steps, which need not necessarily be performed in the exact order: providing at least two card representations to a player, each card representation comprising a symbol, the symbol having a corresponding predetermined value; providing at least two card representations to a dealer, each card representation comprising a symbol, the symbol having a corresponding predetermined value; evaluating a blackjack game outcome by comparing the values of the player and the dealer's card representations, wherein the player wins the blackjack game if the sum of the predetermined values of the player's card representations is higher than the dealer's; using two of the player's card representations for a game of poker; using two of the dealer's card representations for a game of poker; defining values for a plurality of combinations of two card representations; and evaluating a poker game outcome based on the player and the dealer's two card representations, wherein the

Abstract: A tool with a driver, which is translatable along a driver axis, and a motor assembly having an electric motor, a flywheel, a roller and an actuator. The electric motor is selectively operable for driving the flywheel. The actuator is selectively operable for translating the roller such that the roller drives the driver against the flywheel to permit energy to be transmitted from the flywheel to the driver. The electric motor is selected to substantially minimize energy losses associated with bringing a mechanical inertial of the motor assembly to a predetermined rotational speed while substantially minimizing an amount of time that is needed to bring the mechanical inertia to the predetermined rotational speed.