Patents by Inventor Michael Francis Freeman

Michael Francis Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for late introduction of the () hydroxyl group carbapenem ?-lactam antibiotic synthesis
    Patent number: 9458479
    Abstract: The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya, and orthologues likely function similarly in allied streptomyces.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: October 4, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Craig Arthur Townsend, Micah Jeffrey Bodner, Ryan Martin Phelan, Michael Francis Freeman
  • METHOD FOR LATE INTRODUCTION OF THE (8R) HYDROXYL GROUP CARBAPENEM BETA-LACTAM ANTIBIOTIC SYNTHESIS
    Publication number: 20160083760
    Abstract: The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya, and orthologues likely function similarly in allied streptomyces.
    Type: Application
    Filed: September 21, 2015
    Publication date: March 24, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: CRAIG ARTHUR TOWNSEND, MICAH JEFFREY BODNER, RYAN MARTIN PHELAN, MICHAEL FRANCIS FREEMAN
  • Method for late introduction of the ()-hydroxyl group carbapenem ?-lactam antibiotic synthesis
    Patent number: 9139588
    Abstract: The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya, and orthologues likely function similarly in allied streptomyces.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: September 22, 2015
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Craig Arthur Townsend, Micah Jeffrey Bodner, Ryan Martin Phelan, Michael Francis Freeman
  • BIOSYNTHETIC GENE CLUSTER FOR THE PRODUCTION OF PEPTIDE/PROTEIN ANALOGUES
    Publication number: 20140234903
    Abstract: A novel gene cluster encoding polypeptides involved in the generation of bio synthetically unique peptide-based compounds is described. In addition, new methods for biosynthetic engineering and production of modified peptides and proteins are disclosed. Furthermore, new tools for identification of homologue polypeptides and precursor peptides in other species are provided. In addition, peptide-based compounds and fusions of these compounds with functional moieties for treatment of disorders such as tumors are disclosed.
    Type: Application
    Filed: September 5, 2012
    Publication date: August 21, 2014
    Applicant: ETH ZURICH
    Inventors: Jorn Piel, Cristian Gurgui, Michael Francis Freeman, Agustinus Robert Uria, Maximilian Johannes Helf
  • Method for Late Introduction of the (8R)-Hydroxyl Group Carbapenem Beta-Lactam Antibiotic Synthesis
    Publication number: 20130066066
    Abstract: The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya, and orthologues likely function similarly in allied streptomyces.
    Type: Application
    Filed: December 13, 2010
    Publication date: March 14, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Craig Arthur Townsend, Micah Jeffrey Bodner, Ryan Martin Phelan, Michael Francis Freeman