Abstract: A forward-imaging optical coherence tomography probe is provided, comprising: a substantially cylindrical housing comprising: a longitudinal axis; an interior side; a distal end that is optically transparent; and a mirror located at the interior side, adjacent the distal end; an optical fiber located inside the cylindrical housing along the longitudinal axis; a wedge lens located inside the cylindrical housing, adjacent the distal end, the wedge lens configured to receive light from the fiber, and direct the light towards the mirror; and, at least one motor configured to both: rotate the fiber and the wedge lens about the longitudinal axis and inside the cylindrical housing; and, linearly displace the fiber and the wedge lens along the longitudinal axis and inside the cylindrical housing; the mirror configured to: receive light from the wedge lens and reflect the light out of the distal end as the wedge lens moves linearly and rotationally.

Abstract: An optical coherence tomography (“OCT”) system that includes a planarizing transparent material is provided. The OCT system comprises: an OCT probe comprising: a body having a distal end and a proximal end; a positioner adapter located at the proximal end; a connector to an OCT analysis device, the connector located at the proximal end; and, an OCT scan lens located at the distal end; and, a transparent material configured to planarize tissue at a scan plane of the OCT scan lens.

Abstract: A surgical camera system is provided which includes a plurality of imaging devices each having a tunable iris configured to change between at least two different sized numerical apertures. A video stream is produced at a frame rate greater than or equal to about 20 frames per second from first and second images produced by respective sensors and tunable irises of at least two of the imaging devices, the tunable irises controlled to different numerical apertures, the first images acquired at a respective first numerical aperture of a first imaging device and the second images acquired at a respective second numerical aperture of a second imaging device, different from the respective first numerical aperture. The video stream alternates between the first images and the second images so that the video stream results in a three-dimensional effect at a display device when the video stream is rendered thereon.

Abstract: A forward-imaging optical coherence tomography probe is provided, comprising: a substantially cylindrical housing comprising: a longitudinal axis; an interior side; a distal end that is optically transparent; and a mirror located at the interior side, adjacent the distal end; an optical fiber located inside the cylindrical housing along the longitudinal axis; a wedge lens located inside the cylindrical housing, adjacent the distal end, the wedge lens configured to receive light from the fiber, and direct the light towards the mirror; and, at least one motor configured to both: rotate the fiber and the wedge lens about the longitudinal axis and inside the cylindrical housing; and, linearly displace the fiber and the wedge lens along the longitudinal axis and inside the cylindrical housing; the mirror configured to: receive light from the wedge lens and reflect the light out of the distal end as the wedge lens moves linearly and rotationally.

Abstract: An optical imaging system for imaging a target during a medical procedure. The imaging system includes an optical assembly including moveable zoom optics and moveable focus optics. The system includes a zoom actuator and a focus actuator for positioning the zoom and focus optics, respectively. The system includes a controller for controlling the zoom and focus actuators independently in response to received control input. The system includes a camera for capturing an image of the target from the optical assembly. The system may be capable of performing autofocus during a medical procedure.

Abstract: A camera system for providing images with simultaneous high resolution and large depth of field is provided. The system includes: a camera device having a field of view, the camera device configured to automatically acquire: a first image of the field of view at a first numerical aperture; and a second image of the field of view at a second numerical aperture smaller than the first numerical aperture; an image processing unit configured to combine the first image with the second image into a single image by: extracting a higher-resolution in-focus portion of the first image; and replacing a corresponding lower-resolution portion of the second image with the higher-resolution in-focus portion of the first image; and, a display device in communication with the image processing unit, the display device configured to render the single image.

Abstract: A medical imaging system for illuminating tissue samples using three-dimensional structured illumination microscopy is port-based surgery is provided. The system comprises: an image sensor; a mirror device; zoom optics; a light modulator; a processor; and collimating optics configured to convey one or more images from the modulator to the mirror, the mirror configured to convey the images to the zoom optics, the zoom optics configured: to convey the image(s) from the mirror to a tissue sample; and convey one or more resulting images, formed by the image(s) illuminating the sample, back to the mirror, which conveys the resulting image(s) from the zoom optics to the image sensor, and, the processor configured to control the modulator to form the image(s), the image(s) including at least one pattern selected to interact with the sample to generate different depth information in each of resulting image(s).

Abstract: Described are various embodiments of a sensored surgical tool, and surgical intraoperative tracking and imaging system incorporating same. In one embodiment, the surgical tool comprises a rigid elongate tool body having a substantially rigid tool tip to be displaced and tracked within the surgical cavity so to reproducibly locate the tool tip within the cavity. The tool further comprises one or more tool tip cameras and/or pressure sensors operatively disposed along the body at or proximal to the tool tip.

Abstract: A surgical camera system with automatic alternation between two depths of field is provided, comprising: a tunable iris configured to automatically alternate between a first depth of field (“DOF”) and a second DOF larger than the first DOF; one or more lenses configured to collect light using the iris; a body containing the iris and at least a portion of the lenses; a sensor configured to produce images from the light; a video processing unit configured to: produce an image stream from first images and second images produced by the sensor from the light, the first images acquired at the first DOF and the second images acquired at the second DOF; and adjust one or more lighting parameters of the first images and the second images prior to producing the image stream; and, a display device in communication with the video processing unit, configured to render the image stream.

Abstract: A multi-channel optical coherence tomography probe for use in a medical procedure is provided. The probe comprises: a plurality of first optical fibers optically connectable to an OCT light source; a plurality of second optical fibers different from the plurality of first optical fibers; a scanning device comprising: an actuator configured to rotationally move the plurality of second optical fibers between a first position and a second position, relative to the plurality of first optical fibers; and, a mirror configured to, as the plurality of second optical fibers is moving rotationally, convey light from exit faces of the plurality of first optical fibers to entrance faces of the plurality of second optical fibers; and, a housing containing the plurality of second optical fibers.

Abstract: An optical coherence tomography (“OCT”) system that includes a planarizing transparent material is provided. The OCT system comprises: an OCT probe comprising: a body having a distal end and a proximal end; a positioner adapter located at the proximal end; a connector to an OCT analysis device, the connector located at the proximal end; and, an OCT scan lens located at the distal end; and, a transparent material configured to planarize tissue at a scan plane of the OCT scan lens.

Abstract: A modular system for organic sample analysis is disclosed which includes a sample stage including a support platform and a motorized positioning mechanism mounted on the support platform, and a sample holder mounted on the motorized positioning mechanism upon which a sample is placed. A probe support rack is mounted on the support platform and two or more bio-imaging probes mounted on the probe support and arranged in a pre-defined geometry with respect to each other, and at least one bio-imaging probe has a field of view independent of all other bio-imaging probes. The system includes a computer controller connected to the motorized positioning mechanism and the two or more bio-imaging probes. The computer is programmed for controlling motorized positioning mechanism to move the sample holder having the sample located thereon to positions in the field of view of each bio-imaging probe where the sample can be analyzed individually by each of the bio-imaging probes.

Abstract: A surgical imaging system is described. The system includes first and second optical assemblies. Each optical assembly defines a respective optical axis, and each includes a respective set of one or more optics for adjusting field-of-view (FOV) and focus and a respective camera for capturing an image. The system includes a controller for controlling the optical assemblies and for switching the surgical imaging system between a coupled configuration and an uncoupled configuration. In the coupled configuration, the first optical assemblies are controlled to adjust the respective sets of optics and/or the respective optical axes in dependence on each other. In the uncoupled configuration, the optical assemblies are controlled to adjust the respective sets of optics, and the respective optical axes independently of each other.

Abstract: A multispectral synchronized imaging system is provided. A multispectral light source of the system includes: blue, green and red LEDs, and one or more non-visible light sources, each being independently addressable and configured to emit, in a sequence: at least visible white light, and non-visible light in one or more given non-visible frequency ranges. The system further includes a camera and an optical filter arranged to filter light received at the camera, by: transmitting visible light from the LEDs; filter out non-visible light from the non-visible light sources; and otherwise transmit excited light emitted by a tissue sample excited by non-visible light. Images acquired by the camera are output to a display device. A control unit synchronizes acquisition of respective images at the camera for each of blue light, green light, visible white light, and excited light received at the camera, as reflected by the tissue sample.

Abstract: A medical navigation system is provided for acquiring a depth map of a surgical site of interest in a patient. The medical navigation system comprises a camera, a light projecting device, a display, and a controller. The controller has a processor coupled to a memory. The controller is configured to generate a signal provided to the light projecting device to project an edge indicator on the surgical site of interest, generate a signal to operate the camera to perform a focus sweep and capture a plurality of images during the focus sweep where the plurality of images includes the projected edge indicator, receive from the camera data representing the plurality of images captured during the focus sweep, and generate a depth map of the surgical site of interest using the data representing the plurality of images.

Abstract: A system for illumination during a corridor based procedure is provided, comprising: a light source; and, an optical probe comprising: a tube having a distal end, a proximal end and one or more sidewalls there between, the optical probe and the light source arranged so that light from the light source is received by the one or more sidewalls, the one or more sidewalls configured to convey the light to the distal end, the distal end configured to receive the light and illuminate a sample adjacent thereto.

Abstract: An optical coherence tomography (“OCT”) system that includes a planarizing transparent material is provided. The OCT system includes an OCT probe comprising: a body having a distal end and a proximal end; a positioner adapter located at the proximal end; a connector to an OCT analysis device, the connector located at the proximal end; and, an OCT scan lens located at the distal end. The OCT system further includes: a transparent material configured to planarize tissue at a scan plane of the OCT scan lens.

Abstract: Optical probes for port-based corridor surgery are provided, including a device comprising: a surgical tool mounting adaptor configured for mounting to a surgical tool; an optical probe attached to the surgical tool mounting adaptor, the optical probe comprising: an optical interface end; an optical output end, distal the optical interface end, the optical output end comprising illumination optics and collection optics, the illumination optics configured to illuminate tissue proximal the optical output end, the collection optics configured to collect an optical signal from the tissue; one or more illumination optical fibers configured to convey illumination light from the optical interface end to the illumination optics; and, one or more collection optical fibers configured to convey the optical signal collected by the collection optics to the optical interface end.

Abstract: A surgical camera system with automatic alternation between two depths of field is provided, comprising: a tunable iris configured to automatically alternate between a first depth of field (“DOF”) and a second DOF larger than the first DOF; one or more lenses configured to collect light using the iris; a body containing the iris and at least a portion of the lenses; a sensor configured to produce images from the light; a video processing unit configured to: produce an image stream from first images and second images produced by the sensor from the light, the first images acquired at the first DOF and the second images acquired at the second DOF; and adjust one or more lighting parameters of the first images and the second images prior to producing the image stream; and, a display device in communication with the video processing unit, configured to render the image stream.

Abstract: A method, system and apparatus for controlling a surgical navigation system are provided. The method 1 comprises receiving image data at a processor from a tracking system; receiving, at a processor, an identifier of a surgical instrument within a field of view of the tracking system; generating, at the processor, output data based on the identifier of the surgical instrument; and transmitting the output data to at least one output device connected to the processor, for controlling the output device.