Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A respirator comprising: an air supply unit arranged to deliver air at its output.

Abstract: Thread information generated by one or more computing systems is captured. A thread pattern is identified from the captured thread information. The thread pattern is compared to a learned thread pattern. An anomaly is identified in the thread pattern based on a variance from the learned thread pattern. In response to identifying the anomaly in the thread pattern, an action is taken based on the anomalous thread pattern. For example, a user may be notified. The thread patterns may be extended to compare between operating systems, hypervisors, containers, and/or virtual machines.

Abstract: A respirator comprising: an air supply unit arranged to deliver air at its output; headgear comprising a cradle for interfacing with a user’s head, and a face covering from within which the user breathes; a tube to receive air from the air supply unit; and a vibration decoupler, provided between the air supply unit and the head gear interface component, such that in use vibrations from the air supply and tube are reduced.

Abstract: A respirator comprising: an air supply unit arranged to deliver air at its output; headgear comprising a cradle for interfacing with a user's head, and a face covering from within which the user breathes; a tube to receive air from the air supply unit; and an interface component to receive aft from the tube and to deliver said air within the face covering. Components of the respirator and related methods are also described.

Abstract: There is described herein a method of prognosing and/or predicting disease progression in subject with prostate cancer, the method comprising: a) providing a sample containing genetic material from cancer cells; b)determining or measuring at least 2 patient biomarkers regarding the prostate cancer tumor selected from the group consisting of: T category, ACTL6B methylation, TCERGL1 methylation, chr7:61 Mbp inter-chromosomal translocation, ATM single nucleotide variants and MYC copy number aberrations; c) comparing said patient biomarkers to corresponding reference or control biomarkers; and d) determining the likelihood of disease progression; wherein a likelihood of disease progression is higher with each of ACTL6B hyper-methylation, TCERGL1 hypo-methylation, higher T category, and higher incidences of chr7:61 Mbp inter-chromosomal translocation, ATM single nucleotide variants and MYC copy number aberrations, when the difference is statistically significant on comparison with the reference or control biomarke

Abstract: An aquatic accessory adapted for frictional attachment with a shoe being worn by a user comprises a receptacle portion and a fin portion extending outwardly from the receptacle portion. The receptacle portion is adapted to receive at least a portion of an inserted shoe, and frictionally attach with the shoe. Gripping members can be configured and angled in a manner for providing increased frictional attachment between the aquatic accessory and inserted shoe. The accessory can be fabricated from a stretchable material to provide a radial attachment force for enhancing frictional attachment between the aquatic accessory and an inserted shoe.

Abstract: An aquatic accessory adapted for frictional attachment with a shoe being worn by a user comprises a receptacle portion and a fin portion extending outwardly from the receptacle portion. The receptacle portion is adapted to receive at least a portion of an inserted shoe, and frictionally attach with the shoe. Gripping members can be configured and angled in a manner for providing increased frictional attachment between the aquatic accessory and inserted shoe. The accessory can be fabricated from a stretchable material to provide a radial attachment force for enhancing frictional attachment between the aquatic accessory and an inserted shoe.

Abstract: An aquatic accessory adapted for frictional attachment with a shoe being worn by a user comprises a receptacle portion and a fin portion extending outwardly from the receptacle portion. The receptacle portion is adapted to receive at least a portion of an inserted shoe, and frictionally attach with the shoe. Gripping members can be configured and angled in a manner for providing increased frictional attachment between the aquatic accessory and inserted shoe. The accessory can be fabricated from a stretchable material to provide a radial attachment force for enhancing frictional attachment between the aquatic accessory and an inserted shoe.

Abstract: An apparatus includes an upper portion, a sole and a fin. The upper portion is configured to at least partially cover a foot. The sole is coupled to the upper portion and defines a cavity. The fin has a first portion and a second portion. The fin is movable between a first configuration and a second configuration. When in the first configuration, the fin is substantially within the cavity defined by the sole, and the first portion of the fin at least partially overlaps the second portion of the fin. When in the second configuration, the fin extends substantially outside the cavity defined by the sole.

Abstract: An apparatus includes an upper portion, a sole and a fin. The upper portion is configured to at least partially cover a foot. The sole is coupled to the upper portion and defines a cavity. The fin has a first portion and a second portion. The fin is movable between a first configuration and a second configuration. When in the first configuration, the fin is substantially within the cavity defined by the sole, and the first portion of the fin at least partially overlaps the second portion of the fin. When in the second configuration, the fin extends substantially outside the cavity defined by the sole.

Abstract: An apparatus includes an upper portion, a sole and a fin. The upper portion is configured to at least partially cover a foot. The sole is coupled to the upper portion and defines a cavity. The fin has a first portion and a second portion. The fin is movable between a first configuration and a second configuration. When in the first configuration, the fin is substantially within the cavity defined by the sole, and the first portion of the fin at least partially overlaps the second portion of the fin. When in the second configuration, the fin extends substantially outside the cavity defined by the sole.

Abstract: An apparatus includes an upper portion, a sole and a fin. The upper portion is configured to at least partially cover a foot. The sole is coupled to the upper portion and defines a cavity. The fin has a first portion and a second portion. The fin is movable between a first configuration and a second configuration. When in the first configuration, the fin is substantially within the cavity defined by the sole, and the first portion of the fin at least partially overlaps the second portion of the fin. When in the second configuration, the fin extends substantially outside the cavity defined by the sole.

Abstract: A cement mix suitable for blocking or plugging an abandoned pipeline or back filling a mine shaft, tunnel or excavations contains Portland cement or a cement blend of two components selected from Portland cement, fly ash, pozzolan, slag, silica fume and gypsum; diatomaceous earth; zeolite and an inorganic salt accelerator. The cement mix may further contain an alkali metasilicate and/or alkali silicate. A cementitious slurry, formulated from the cement mix, may have a density less than or equal to 1500 kg/m3, and exhibits good compressive strength.

Abstract: A cement mix suitable for blocking or plugging an abandoned pipeline or back filling a mine shaft, tunnel or excavations contains (i) Portland cement or a mixture of at least two components selected from Portland cement, fly ash, slag, silica fume, gypsum, bentonite and limestone; (ii) diatomaceous earth; (iii) zeolite, (iv) an aluminum silicate and (v) an inorganic salt accelerator. The cement mix may further contain an alkali metasilicate and/or alkali silicate. A cementitious slurry, formulated from the cement mix, may have a density less than or equal to 1500 kg/m3, and exhibits good compressive strength.

Abstract: A cement mix which is suitable for cementing in subterranean formations to provide zonal isolation or for blocking or plugging an abandoned pipeline or back filling a mine shaft, tunnel or excavation contains Portland cement or a mixture of two components selected from Portland cement, fly ash, slag, silica fume, gypsum, limestone and bentonite; and diatomaceous earth, preferably having a BET nitrogen adsorption specific surface area between from about 30 to about 100 m2/g. The cement mix may further contain an alkali metasilicate and/or alkali silicate, zeolite and/or aluminum silicate, an accelerator, such as an inorganic salt, and/or an alkaline metal oxide, as well as a lightweight density modifying agent, including glass, ceramic or plastic spheres. A cementitious slurry, formulated from the cement mix, has a density less than or equal to 1500 kg/m3 and exhibits good compressive strength.