Abstract: A software algorithm that matches tandem mass spectra created simultaneously and automatically to theoretical peptide sequences derived from a protein database is disclosed. The program characterizes shotgun proteomic data sets obtained from proteins (such as histones) that possess extensive posttranslational modifications that are often difficult to characterize. Data is searched against all theoretical peptides including all combinations of modifications. The program returns four scores to assess the quality of match. The employed algorithm is sensitive to mass accuracy. For high mass accuracy data, a false positive rate as low as 2% may be achieved. Monte Carlo Simulations were also used to obtain a solution to statistical models and calculate statistical scores. The program can also be used to automatically and directly identify disulfide linked proteins and peptides in tandem mass spectra without chemical reduction and/or other derivatization using a probabilistic scoring model.

Abstract: A hair clip includes a pair of semi-annular band portions and a living hinge that extends between, and is integrally formed with proximal ends of the band portions to thereby join the band portions together for pivotal movement between open and closed positions. A locking depression is formed at the distal end of one band portion and a locking projection formed at the distal end of the other band portion. The locking projection and depression are mutually engageable in a snap-fit arrangement to thereby secure the band portions together in the closed position.

Abstract: A hair clip includes a pair of semi-annular band portions and a living hinge that extends between, and is integrally formed with proximal ends of the band portions to thereby join the band portions together for pivotal movement between open and closed positions. A locking depression is formed at the distal end of one band portion and a locking projection formed at the distal end of the other band portion. The locking projection and depression are mutually engageable in a snap-fit arrangement to thereby secure the band portions together in the closed position.

Abstract: A surgical trocar instrument is provided which includes a trocar spike designed to prevent coring of the needlepoint of a trocar tube and which is secured to a knob or holding assembly in a manner that the trocar tube resists relative rotational movement and the spike assembly is biased outwardly of the needlenose of the trocar tube, but the bias may be overcome upon insertion of the trocar tube through a cavity wall, with the bias moving the spike assembly outwardly of the trocar tube to prevent coring during additional surgical maneuvers.

Abstract: A surgical trocar instrument is provided which includes a trocar spike designed to prevent coring of the needlepoint of a trocar tube and which is secured to a knob or holding assembly in a manner that the trocar tube resists relative rotational movement and the spike assembly is biased outwardly of the needlenose of the trocar tube, but the bias may be overcome upon insertion of the trocar tube through a cavity wall, with the bias moving the spike assembly outwardly of the trocar tube to prevent coring during additional surgical maneuvers.