Abstract: A method for controlling the use of oligonucleotide sequences released from arrays, comprises synthesizing a chemical array of oligonucleotides on a substrate under conditions for producing an array of cleavable oligonucleotides that are blocked from enzymatic reactions after cleavage. Methods may also include receiving a chemical array of cleavable oligonucleotides on a substrate, and cleaving the oligonucleotides from the array, wherein the oligonucleotides are blocked from enzymatic reactions after cleavage. Arrays, populations of oligonucleotides and kits are also provided to facilitate the methods.

Abstract: A system is described which comprises an input manager for receiving probe request information from a probe requester and a processing module configured to identify a probe sequence associated with the probe request information, wherein the processing module associates a flag with one or more nucleic acid sequences corresponding to the probe request associated with a predefined sequence characteristic. Methods of using the system and computer program products for implementing the methods are also described.