Abstract: Embodiments include a method, system, and computer program product for maintaining continuous availability. An embodiment of the present invention includes receiving a unit of work data. The unit of work data is distributed among the plurality of workloads using either an active/standby configuration, an active/query configuration, an active/partitioned configuration, or an active/active configuration. A primary workload is selected from a plurality of workloads to process the unit of work data based on a workload distribution rule. It is determined if the primary workload is capable of processing the unit of work data based on user configurable settings. If the primary site is capable of processing the unit of work data then the unit of work data is transmitted to the primary workload. Otherwise the unit of work data is transmitted to a secondary workload. The unit of work data is replicated between the primary workload and the secondary workload.

Abstract: The invention provides an automated method of identifying a plurality of different polymorphisms within two or more related nucleic acid sequences. The method consists of: (a) obtaining a data set comprising a nucleic acid sequence assembly and a plurality of sequence characteristic parameters associated with said assembly; (b) indexing said nucleic acid assembly and said plurality of sequence characteristic parameters in a database; (c) selecting a region of said nucleic acid assembly having sequence characteristic parameters indicative of a polymorphic sequence, and (d) displaying two or more nucleic acid sequences of said region, said two or more sequences identifying different polymorphisms within said nucleic acid assembly. Also provided is a method of identifying a nucleic acid containing an indel region within a set of related nucleic acid sequences.

Abstract: This invention relates to isolated nucleic acids comprising single nucleotide polymorphisms of the human COX-2 gene and the proteins encoded by these nucleotides. The invention also relates to pharmacogenomics. The invention provides methods of using the polymorphisms in diagnostics and therapeutics.

Abstract: A sensing apparatus, for use in adverse conditions comprising a housing having an aperture formed therein. A generally spherically shaped housing, which is larger in size than the aperture, partially extends through the aperture. The generally spherically shaped housing supports a desired sensor and is supported for rotation about an axis of rotation. A drive mechanism is provided for rotating the generally spherically shaped housing to and fro about its rotational axis from a use position, in which the sensor is positioned outside the housing to obtain sensor measurements, to a retracted position in which the sensor is completely accommodated within the housing and sheltered from the elements. A peripheral scraping ring is mounted circumferentially about the aperture in close proximity to an exterior surface of the generally spherically shaped housing but spaced therefrom.