Patents by Inventor Michael Gögler
Michael Gögler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11830215Abstract: An overview image of a sample carrier is obtained in a method for ascertaining a measurement location of a microscope. A mapping or homography is determined, by means of which the overview image is perspectively convertible into a plan view image on the basis of a height of the sample carrier. The measurement location is identified, with the aid of the determined mapping/homography, in the overview image or in an output image derived therefrom.Type: GrantFiled: January 15, 2021Date of Patent: November 28, 2023Assignee: Carl Zeiss Microscopy GmbHInventors: Manuel Amthor, Daniel Haase, Michael Gögler
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Patent number: 11774739Abstract: A method for regulating a light source of a microscope that illuminates an object, said method including specifying an intended value of an energy parameter of illumination radiation on the object; producing illumination radiation; providing an objective for focusing illumination radiation onto the object; ascertaining a transmission property of the objective for the illumination radiation; output coupling a component of the illumination radiation upstream of the objective as measurement radiation and measuring an actual value of the energy parameter of the measurement radiation; providing a relationship between energy parameters of the measurement radiation and energy parameters of the illumination radiation on the object, and setting the light source in such a way that the actual value of the energy parameter measured for the measurement radiation corresponds to the intended value of the energy parameter according to the relationship.Type: GrantFiled: November 22, 2017Date of Patent: October 3, 2023Assignee: Carl Zeiss Microscopy GmbHInventors: Michael Gögler, Thomas Ohrt
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Patent number: 11630295Abstract: The present invention relates to an illumination module for a microscope apparatus, comprising a plurality of monochromatic sources and a control device, wherein the control device is configured to control states of the plurality of the monochromatic sources, and the control device includes a selecting and switching module which realizes a switch among the plurality of monochromatic sources in response to an operation of the user. The design of the illumination module makes the microscope apparatus compact in structure, highly reliable, convenient in use, and extremely enhancing the work efficiency of the user. The present invention also relates to a method for controlling the illumination module, and a microscope apparatus comprising the illumination module.Type: GrantFiled: January 9, 2020Date of Patent: April 18, 2023Assignee: CARL ZEISS MICROSCOPY GMBHInventors: Michael Goegler, Jochen Ingo Schweizer, Lei Cai, Genxin Dou, Changqing Liu
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Publication number: 20230108453Abstract: Various examples of the disclosure relate to techniques to count cells in a microscopy image and/or to determine a degree of confluence of the cells in the microscopy image. To that end, machine-learned algorithms are used.Type: ApplicationFiled: September 30, 2022Publication date: April 6, 2023Applicant: Carl Zeiss Microscopy GmbHInventors: Manuel AMTHOR, Daniel HAASE, Michael GÖGLER
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Publication number: 20230105948Abstract: Various examples of the disclosure relate to aspects associated with training a machine-learned algorithm configured to count cells in a microscopy image or to determine a degree of confluence of the cells.Type: ApplicationFiled: September 28, 2022Publication date: April 6, 2023Applicant: Carl Zeiss Microscopy GmbHInventors: Manuel AMTHOR, Daniel HAASE, Michael GÖGLER
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Patent number: 11586025Abstract: A method for the microscopy scanning of a specimen. An immersion medium is used between a slide and a microscope objective, said immersion medium wetting a surface of the slide, and the microscope objective being relatively displaced over the surface of the slide for imaging. The surface is provided with a coating which repels the immersion medium.Type: GrantFiled: August 8, 2018Date of Patent: February 21, 2023Assignee: Carl Zeiss Microscopy GmbHInventors: Thomas Ohrt, Michael Goegler, Thorsten Kues
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Patent number: 11543643Abstract: A microscope objective for imaging a specimen using a microscope, the microscope objective having a front lens enclosed by a surround and being designed for microscopy with an immersion liquid. In the microscope objective, the front lens and/or the surround thereof is provided with a coating which can be switched between a state which repels the immersion liquid and a state which does not repel the immersion liquid.Type: GrantFiled: August 6, 2018Date of Patent: January 3, 2023Assignee: Carl Zeiss Microscopy GmbHInventors: Thomas Ohrt, Michael Goegler, Thorsten Kues
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Patent number: 11493746Abstract: An optical apparatus having an illumination module with a carrier, which has at least one light-transmissive region, for example. The illumination module has a plurality of light sources, which are arranged on the carrier.Type: GrantFiled: April 11, 2017Date of Patent: November 8, 2022Assignee: Carl Zeiss Microscopy GmbHInventors: Lars Stoppe, Michael Goegler, Thomas Ohrt
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Patent number: 11474335Abstract: A microscope objective for imaging a specimen using a microscope, the microscope objective being designed as an air objective for microscopy without an immersion medium or as an oil immersion objective for microscopy with an oil-based immersion medium or as a water immersion objective for microscopy with a water-based immersion medium. The front lens of the microscope objective is provided with a coating which repels an immersion medium and is lipophobic and hydrophobic if the objective is an air objective, only lipophobic if the objective is a water immersion objective, and only hydrophobic if the objective is an oil immersion objective.Type: GrantFiled: August 6, 2018Date of Patent: October 18, 2022Assignee: Carl Zeiss Microscopy GmbHInventors: Thomas Ohrt, Michael Goegler, Thorsten Kues
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Publication number: 20220284719Abstract: Various examples relate to determining a number and/or a confluency of cells in a microscopy image. To that end, the microscopy image is firstly rescaled and then processed.Type: ApplicationFiled: March 1, 2022Publication date: September 8, 2022Applicant: Carl Zeiss Microscopy GmbHInventors: Manuel AMTHOR, Daniel HAASE, Michael GÖGLER
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Patent number: 11300782Abstract: A microscope and a microscopy method for imaging an object, wherein use is made of a microscope comprising an objective which defines an optical axis and a focal plane perpendicular thereto, and an adjustable correction optical unit which, at the objective, corrects a spherical aberration occurring when imaging the object with a certain depth position of the focal plane. The method comprises the following steps: determining an actual type of object; reading a database in which refractive indices of different types of objects are stored in order to determine the refractive index of the object; using a relationship between the refractive index and the spherical aberration caused by the object in order to ascertain an adjustment value of the correction optical unit such that there is a reduction in the spherical aberration in the focal plane; adjusting the correction optical unit to the adjustment value; and imaging the object.Type: GrantFiled: March 17, 2021Date of Patent: April 12, 2022Assignee: Carl Zeiss Microscopy GmbHInventors: Michael Goegler, Juergen Fechti
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Publication number: 20220091412Abstract: A microscope and a microscopy method for imaging an object, wherein use is made of a microscope comprising an objective which defines an optical axis and a focal plane perpendicular thereto, and an adjustable correction optical unit which, at the objective, corrects a spherical aberration occurring when imaging the object with a certain depth position of the focal plane. The method comprises the following steps: determining an actual type of object; reading a database in which refractive indices of different types of objects are stored in order to determine the refractive index of the object; using a relationship between the refractive index and the spherical aberration caused by the object in order to ascertain an adjustment value of the correction optical unit such that there is a reduction in the spherical aberration in the focal plane; adjusting the correction optical unit to the adjustment value; and imaging the object.Type: ApplicationFiled: March 17, 2021Publication date: March 24, 2022Inventors: Michael GOEGLER, Juergen FECHTI
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Publication number: 20220021849Abstract: The invention relates to a smart photo-microscope system, including a microscope and a camera attached to the microscope to photograph a microscope sample. In an exemplary configuration, the camera includes a built-in processor and is connected with the microscope to receive and process information from the microscope. In another exemplary configuration, the smart photo-microscope system further includes a single board computer (SBC), which includes a built-in processor and is connected with the microscope and camera to receive and process information from the microscope and/or camera.Type: ApplicationFiled: November 22, 2019Publication date: January 20, 2022Inventors: Shukuan XU, Luying QIANG, Weiqiang GUO, Lei CAI, Zheng WAN, Hexin WANG, Michael GOEGLER
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Patent number: 11092794Abstract: An optical apparatus comprises an illumination module (100) comprising a carrier (110), which has at least one light-transmissive region (112), for example. The illumination module (100) comprises a plurality of light sources (111), which are arranged on the carrier (110).Type: GrantFiled: April 26, 2017Date of Patent: August 17, 2021Assignee: CARL ZEISS MICROSCOPY GMBHInventors: Lars Stoppe, Michael Goegler, Thomas Ohrt
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Publication number: 20210239954Abstract: An optical apparatus having an illumination module with a carrier, which has at least one light-transmissive region, for example. The illumination module has a plurality of light sources, which are arranged on the carrier.Type: ApplicationFiled: April 11, 2017Publication date: August 5, 2021Applicant: Carl Zeiss Microscopy GmbHInventors: Lars STOPPE, Michael GOEGLER, Thomas OHRT
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Publication number: 20210225026Abstract: An overview image of a sample carrier is obtained in a method for ascertaining a measurement location of a microscope. A mapping or homography is determined, by means of which the overview image is perspectively convertible into a plan view image on the basis of a height of the sample carrier. The measurement location is identified, with the aid of the determined mapping/homography, in the overview image or in an output image derived therefrom.Type: ApplicationFiled: January 15, 2021Publication date: July 22, 2021Inventors: Manuel Amthor, Daniel Haase, Michael Gögler
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Patent number: 11061216Abstract: A microscope for imaging an object, comprising a lens assembly, which defines an optical axis and a focal plane perpendicular thereto, and correction optics, which are adjustable for adjustment to a depth position and which correct a spherical aberration on the lens assembly which occurs during imaging of the object at a specific depth position of the focal plane. The microscope may be used to determine a phase difference of radiation from a first lateral region and a second lateral region of the object, and to use a previously known connection between the phase difference and a modification of the spherical aberration caused thereby in order to determine an adjustment value of the correction optics, such that the spherical aberration is reduced when imaging the second region.Type: GrantFiled: March 14, 2018Date of Patent: July 13, 2021Assignee: Carl Zeiss Microscopy GmbHInventors: Michael Goegler, Thomas Ohrt, Markus Sticker
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Publication number: 20210199955Abstract: A microscope and a microscopy method for imaging an object, wherein use is made of a microscope comprising an objective which defines an optical axis and a focal plane perpendicular thereto, and an adjustable correction optical unit which, at the objective, corrects a spherical aberration occurring when imaging the object with a certain depth position of the focal plane. The method comprises the following steps: determining an actual type of object; reading a database in which refractive indices of different types of objects are stored in order to determine the refractive index of the object; using a relationship between the refractive index and the spherical aberration caused by the object in order to ascertain an adjustment value of the correction optical unit such that there is a reduction in the spherical aberration in the focal plane; adjusting the correction optical unit to the adjustment value; and imaging the object.Type: ApplicationFiled: March 17, 2021Publication date: July 1, 2021Inventors: Michael GOEGLER, Juergen FECHTI
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Publication number: 20200355901Abstract: A microscope objective for imaging a specimen using a microscope, the microscope objective being designed as an air objective for microscopy without an immersion medium or as an oil immersion objective for microscopy with an oil-based immersion medium or as a water immersion objective for microscopy with a water-based immersion medium. The front lens of the microscope objective is provided with a coating which repels an immersion medium and is lipophobic and hydrophobic if the objective is an air objective, only lipophobic if the objective is a water immersion objective, and only hydrophobic if the objective is an oil immersion objective.Type: ApplicationFiled: August 6, 2018Publication date: November 12, 2020Inventors: Thomas OHRT, Michael GOEGLER, Thorsten KUES
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Patent number: 10823948Abstract: A microscope for imaging an object, comprising a lens for imaging the object through an imaging beam path, a light source for generating illumination radiation, at least one optical element for coupling the illumination radiation into the imaging beam path such that a common beam path is formed between the optical element and the lens, wherein the imaging radiation path runs through the common beam path, and the illumination radiation is guided through the common beam path. The microscope also comprises a monitoring device for measuring an energy parameter of the illumination radiation, said monitoring device determining an energy parameter of radiation which is incident on the monitoring device, and a beam splitter device which is arranged in the common beam path upstream of the lens in the illuminating direction and couples measurement radiation out of the illumination radiation onto the monitoring device.Type: GrantFiled: November 22, 2017Date of Patent: November 3, 2020Assignee: Carl Zeiss Microscopy GmbHInventor: Michael Gögler