Abstract: The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract: This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.

Abstract: The invention provides an isolated nucleic acid molecule encoding the polypeptide GALAT1 having galacturonosyltransferase (GalAT) activity. The Arabidopsis GALAT1 sequence disclosed represents the first pectin biosynthetic glycosyltransferase gene isolated from plants. The invention further provides 14 GALAT and 10 GALAT-like gene superfamily members. The identification of the GALAT gene superfamily offers new opportunities to modulate pectin synthesis in vivo and in vitro by modulating the GALAT gene, for example, transgenic plants that produce modified pectins can be generated by altering the GALAT gene. Since modified pectins are predicted to affect plant growth, development, and plant defense responses, the transgenic plants are expected to have improved agricultural value. The modified pectins isolated from such transgenic plants are useful as gelling and stabilizing agents in the food, neutraceutical, and pharmaceutical industries.

Abstract: Compounds of the general formula (I) wherein R1 represents halogen, R2 and R3 represent H or halogen, and R4 represents C3-8-cycloalkyl or optionally substituted phenyl, pharamceutical compositions containing such materials, and methods of using such materials in the treatment of various diseases are disclosed and claimed.

Abstract: The invention relates to compounds of formula (I), to methods for their production and to the use thereof as medicaments.

Abstract: An alignment unit is provided for aligning signals transmitted between a core clock domain and a bus clock domain. The alignment unit includes at least one alignment latch connected along each signal path between the core and bus clock domains. For critical path signal lines, the alignment unit also includes a latch bypass to allow critical signals to bypass the latch in circumstances when the core and bus clock signals are already aligned. The bypass mechanism includes a multiplexer which transmits the critical path signal through a tristate buffer if the clock signals are aligned or through a latch and a tristate buffer if the clock signals are unaligned. By bypassing the latch when the signals are aligned, latch propagation delays are avoided. Method and apparatus embodiments are disclosed.

Abstract: A circuit for providing digital output signals carrying large amounts of currents without generating large transients at an output terminal connected to a load comprising apparatus for providing gradually increasing amounts of current of a first polarity to the output terminal, apparatus for providing gradually increasing amounts of current of a second polarity to the output terminal, apparatus for utilizing the apparatus for providing gradually increasing amounts of current of a first polarity to the output terminal to place the output terminal at a voltage level required for input signals, apparatus for providing a high impedance path to hold the output terminal at the voltage level required for input signals, and apparatus for disabling the apparatus for providing gradually increasing amounts of current of a first polarity and the apparatus for providing gradually increasing amounts of current of a second polarity to the output terminal.

Abstract: A circuit for providing digital output signals carrying large amounts of currents without generating large transients including apparatus for providing a first current path for providing current at a first rate and a first polarity, apparatus for providing a second current path for providing current at the first rate and the first polarity after a first delay, and apparatus for providing a third current path for providing current of the first polarity at a rate greater than the first rate and sufficient for a load connected thereto after a second delay equal to the first delay whereby the current available at the load has built to a level sufficient to sustain the load prior to the provision of the third current.