Abstract: A two-stage hydrotreating process is disclosed wherein a hydrocarbon stream is first desulphurized followed by a dehydrogenation step, which process comprises in combination contacting the feed and hydrogen over a hydrotreating catalyst at hydrotreating conditions, heating the hydrotreated effluent and hydrogen-rich gas from the hydrotreating reactor and contacting said effluent and hydrogen gas over a hydrotreating catalyst in a post-treatment reactor at a temperature sufficient to increase the polyaromatic hydrocarbon content and lower the hydrogen content of said effluent.

Abstract: A hybrid fusion protein comprising a first antigenic amino acid sequence fused to a second amino acid sequence substantially homologous to B2M or a fragment thereof.

Abstract: This invention relates to the refining of petroleum products, and more particularly to an integrated hydroprocessing scheme involving a hydrocracking stage and subsequent dewaxing stage. Materials boiling in the middle distillate or lube oil range may be dewaxed. The bottoms streams (and optionally, other streams) of each stage are maintained separately from one another, during processing. Dewaxing may occur using either hydroisomerization catalysts or shape-selective catalysts or both in series. One embodiment employs a baffle in the flash zone of a fractionator to separate bottoms streams from each other. Alternatively, the effluent from the hydrocracking stage may be processed separately from the effluent from the dewaxing stage. The bottoms fraction from the dewaxing stage may be recycled back to the hydrocracking stage for further processing or used as lube base stock.

Abstract: Hydrocarbon feedstocks are hydroprocessed in parallel reactors, while hydrogen flows in series between the reactors. A first hydrocarbon feedstock and a hydrogen-rich recycle gas stream are introduced to a first reactor, where a first reactor effluent stream is produced and fed to a first separator, which separates the first reactor effluent stream into a first hydrogen-rich gas stream and a first hydroprocessed product stream. The first hydrogen-rich gas stream and a second hydrocarbon feedstock are fed to a second reactor, where a second reactor effluent stream is produced and fed to a second separator, which separates the second reactor effluent stream into a second hydrogen-rich gas stream and a second hydroprocessed product stream. A make-up hydrogen stream is added to the second hydrogen-rich gas to form the hydrogen-rich recycle gas stream that is compressed and fed to the first reactor.

Abstract: An integrated three-column process for recovering hydrocarbon distillate products from a hydroprocessing or hydrocracking reactor effluent stream and a hydrocarbon distillate product recovery train are disclosed. According to the present recovery process, an effluent stream from the cracking reactor is cooled and separated into light and heavy phase streams. The heavy phase stream is depressurized and stripped of light end components in a steam stripping column. The light phase stream is further cooled to separate a liquid stream which is combined with the light ends from the stripper and fed to a debutanizer. A C.sub.4 -rich light end stream taken overhead from the debutanizer is condensed to produce LPG product stream(s). A C.sub.4 -lean heavy end stream removed from the bottoms of the debutanizer is combined with a heavy end bottoms stream from the stripper and fed to a fractionator for fractionation into product distillate streams such as light and heavy naphtha, jet fuel, diesel oil, and the like.

Abstract: An integrated middle distillate upgrading process and unit are disclosed. A middle distillate side-stream of a conventional single stage hydrocracking process is circulated to a hydrotreating stage such as an aromatics saturation reactor and/or a catalytic dewaxing reactor to effect middle distillate upgrade. The upgraded product is then finished in a fractionation stage side-stripper column. The integrated hydrotreating reactor can share the duty of existing hydrocracker stage equipment and take advantage of existing process heat to eliminate the need for much of the equipment generally required by a stand-alone hydrotreating reactor of the prior art.

Abstract: Relatively inactive fusion proteins are activatable by enzymes of the clotting cascade to have fibrinolytic and/or clot formation inhibition activity. For example, a fusion protein comprising two hirudin or streptokinase molecules, linked by a cleavable linkage sequence, may be cleaved to yield anti-thrombotic hirudin or fibrinolytic streptokinase by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation. Cleavable streptokinase/hirudin heterodimers are claimed.

Abstract: High quality lubricating oil base stocks are produced from crude oils that contain significant concentrations of aromatic compounds in their higher boiling fractions. First, the crude is fractionated. After the residua fraction has been deasphalted, it is combined with the gas oil fraction. The resultant combined fraction is hydrocracked. The hydrocrackate is separated into a light fraction and a heavy fraction. The heavy fraction is hydrodewaxed, then hydrofinished. The hydrofinished product is combined with the light fraction and distilled into products including middle distillate fuel products and lubricating oil base stocks. The lubricating oil base stocks have high VI.