Patents by Inventor Michael G. Kornacker

Michael G. Kornacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PAR4 agonist peptides
    Patent number: 9605024
    Abstract: Protease activated receptor 4 (PAR4) agonist peptides are disclosed. These peptides are useful for developing robust PAR4 receptor assays.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: March 28, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael G. Kornacker, Claudio Mapelli, Douglas J. Riexinger
  • PAR4 AGONIST PEPTIDES
    Publication number: 20160304560
    Abstract: The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.
    Type: Application
    Filed: February 23, 2016
    Publication date: October 20, 2016
    Inventors: Michael G. KORNACKER, Claudio MAPELLI, Douglas J. RIEXINGER
  • PAR4 agonist peptides
    Patent number: 9303065
    Abstract: The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: April 5, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael G. Kornacker, Claudio Mapelli, Douglas James Riexinger
  • PAR4 AGONIST PEPTIDES
    Publication number: 20150158910
    Abstract: The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 11, 2015
    Inventors: Michael G. KORNACKER, Claudio Mapelli, Douglas James Riexinger
  • PAR4 agonist peptides
    Patent number: 8927688
    Abstract: PAR4 agonist peptides are disclosed. These peptides are useful for developing robust PAR4 receptor assays.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: January 6, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael G. Kornacker, Claudio Mapelli, Douglas James Riexinger
  • PAR4 AGONIST PEPTIDES
    Publication number: 20130289238
    Abstract: The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.
    Type: Application
    Filed: April 24, 2013
    Publication date: October 31, 2013
    Inventors: Michael G. Kornacker, Claudio Mapelli, Douglas James Riexinger
  • Methods of diagnosing colon adenocarcinoma using mRNA encoding the human g-protein coupled receptor, HGPRBMY23
    Patent number: 7713699
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: May 11, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Thomas C. Nelson, Chandra S. Ramanathan, Rolf-Peter Ryseck, Michael G. Kornacker
  • Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
    Patent number: 7314726
    Abstract: The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: January 1, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael G. Kornacker, Robert A. Copeland, Joseph Hendrick, Zhihong Lai, Claudio Mapelli, Mark Richard Witmer, Jovita Marcinkeviciene, William Metzler, Ving Lee, Douglas James Riexinger
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20040214317
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 13, 2003
    Publication date: October 28, 2004
    Inventors: Peter Battaglino, John N. Feder, Gabriel Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela M. Cacace, Lauren E. Barber, Donald R. Hawken, Michael G. Kornacker
  • Modulators of human G-protein coupled receptors
    Publication number: 20040209808
    Abstract: The present invention relates to isolated peptides, and fragments and variants thereof, that bind to human G-protein coupled receptors, particularly G-protein coupled receptors belonging to the P2Y family of receptors. Also related are polypeptides comprising these peptides, and antibodies that specifically bind to these peptides and polypeptides. The invention further relates to polynucleotides encoding these peptides and polypeptides, vectors comprising these polynucleotides, and host cells comprising these vectors. In addition, the invention relates to methods for producing and isolating the disclosed peptides, polypeptides, antibodies, polynucleotides, vectors, and host cells. The invention also relates to methods for preventing, diagnosing, ameliorating, and treating disorders associated with HGPRBMY3 and related P2Y G-protein coupled receptors, including aberrant cell growth, immunological conditions, and diseases or disorders related to immune, brain, breast, cervix, kidney, and colon tissues.
    Type: Application
    Filed: February 10, 2004
    Publication date: October 21, 2004
    Inventor: Michael G. Kornacker
  • Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
    Publication number: 20040121412
    Abstract: The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
    Type: Application
    Filed: October 15, 2003
    Publication date: June 24, 2004
    Inventors: Michael G. Kornacker, Robert A. Copeland, Joseph Hendrick, Zhihong Lai, Claudio Mapelli, Mark Richard Witmer, Jovita Marcinkeviciene, William Metzler, Ving Lee, Douglas James Riexinger
  • Novel human G-protein coupled receptor, HGPRBMY4, and methods of use thereof
    Publication number: 20040121330
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and polypeptide of the present invention. Methods for treating, diagnosing, preventing, and screening for neurological, cardiovascular, and prostate-, colon-, breast-, or lung-related conditions or disorders are described.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: John N. Feder, Gabriel A. Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren E. Barber, Michael G. Kornacker, Rolf-Peter Ryseck, Kelly L. Bennett, Thomas C. Nelson
  • Novel human G-protein coupled receptor, HGPRBMY23, expressed highly in kidney
    Publication number: 20030224458
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: February 26, 2003
    Publication date: December 4, 2003
    Inventors: Lauren E. Barber, Angela Cacace, John N. Feder, Thomas C. Nelson, Chandra S. Ramanathan, Rolf-Peter Ryseck, Michael G. Neubauer, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY14, related to the orphan GPCR, GPR73
    Publication number: 20030198976
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY14 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY14 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: November 14, 2002
    Publication date: October 23, 2003
    Inventors: John N. Feder, Chandra S. Ramanathan, Thomas C. Nelson, Michael G. Kornacker, Rolf-Peter Ryseck, Angela Cacace, Lauren E. Barber, David K. Bol
  • Novel human G-protein coupled receptor, HGPRBMY3, expressed highly in immune -and colon-related tissues
    Publication number: 20030186360
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological conditions, and diseases or disorders related to immune tissues, brain, and colon are illustrated.
    Type: Application
    Filed: September 26, 2001
    Publication date: October 2, 2003
    Inventors: John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren Barber, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY7, expressed highly in spinal cord
    Publication number: 20030186265
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological diseases, neurological conditions, and diseases or disorders related to the spinal cord and brain, as well as breast and colon, are illustrated.
    Type: Application
    Filed: September 25, 2002
    Publication date: October 2, 2003
    Inventors: Peter Battaglino, John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Ryan Westphal, Donald R. Hawken, Angela M. Cacace, Lauren E. Barber, Michael G. Kornacker, David K. Bol
  • Novel human G-protein coupled receptor, HGPRBMY3, expressed highly in immune- and colon- related tissues
    Publication number: 20030175748
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological conditions, and diseases or disorders related to immune tissues, brain, breast, cervix, kidney, and colon are illustrated.
    Type: Application
    Filed: October 10, 2002
    Publication date: September 18, 2003
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren E. Barber, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY6, expressed highly in small intestine
    Publication number: 20030170671
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing and screening for disorders associated with aberrant cell growth and those related to the small intestine and colon are illustrated.
    Type: Application
    Filed: September 27, 2002
    Publication date: September 11, 2003
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela M. Cacace, Lauren E. Barber, Michael G. Kornacker, Thomas C. Nelson, David K. Bol
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20030054444
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 14, 2001
    Publication date: March 20, 2003
    Inventors: Peter Battaglino, John N. Feder, Gabe Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela Cacace, Lauren Barber, Donald R. Hawken, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY6, expressed highly in small intestine
    Publication number: 20030044892
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, aritisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing and screening for disorders associated with aberrant cell growth and those related to the small intestine and colon are illustrated.
    Type: Application
    Filed: September 26, 2001
    Publication date: March 6, 2003
    Inventors: John N. Feder, Gabe Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren Barber, Michael G. Kornacker