Patents by Inventor Michael G. Mauk

Michael G. Mauk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190017084
    Abstract: Disclosed herein are methods for multiple stage isothermal amplification of nucleic acid comprising a first substantially isothermal amplification reaction on the nucleic acid to generate a first amplification product and at least one substantially isothermal amplification reaction on the first amplification product to generate at least one second amplification product in an amount sufficient for recovery, testing, or characterization.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 17, 2019
    Applicant: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. BAU, Michael G. MAUK, Jinzhao SONG, Changchun LIU
  • Publication number: 20180193834
    Abstract: A testing device that integrates nucleic acid isolation, isothermal amplification and detection wherein a sample and reagents are transported through a capture/binding membrane by capillary forces and the positioning of a slidebar that supports said binding membrane. Flow control and fluid actuation are effected by the position of said slidebar which makes a fluidic connection through the capture membrane situated between a reservoir of liquid on the device and an absorbing pad, and where a sequence of operations for sample loading, washing, optionally amplification, and optical detection of analytes can be done conveniently and rapidly at the point of care. With minimal operator interaction, this device can lyse, isolate, amplify, and detect nucleic acids from clinical specimens and environmental samples.
    Type: Application
    Filed: April 17, 2017
    Publication date: July 12, 2018
    Inventors: Michael G. Mauk, Dharma Teja Varapula, Sirisha Phanithra Gutta
  • Patent number: 9976176
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: May 22, 2018
    Assignees: The Trustees of the University of Pennsylvania, New York University
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daniel Malamud, Xianbo Qiu
  • Publication number: 20170343533
    Abstract: The present disclosure provides devices and methods using Plasma coil r separating a fluid—e.g., plasma or serum—from whole blood. In some embodiments, the devices and methods use hydrophobic or superhydrophobic surfaces to encourage whole blood to contact a selective membrane that extracts the desired fluid component from the blood.
    Type: Application
    Filed: November 9, 2015
    Publication date: November 30, 2017
    Inventors: Changchun LIU, Haim H. BAU, Michael G. MAUK
  • Publication number: 20170096702
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Application
    Filed: September 8, 2016
    Publication date: April 6, 2017
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daniel Malamud, Xianbo Qiu
  • Publication number: 20160310904
    Abstract: A plasma separator includes a vertical chamber with a membrane or membranes partially or fully covering the internal chamber walls and forming an inner cavity to accommodate whole blood. The plasma separator further includes a plasma collection space separated from the inner cavity with one or more membranes and a plasma removal port.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 27, 2016
    Inventors: Changchun LIU, Haim H. BAU, Michael G. MAUK
  • Patent number: 9476102
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: October 25, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daneil Malamud, Xianbo Ceiu
  • Patent number: 9409166
    Abstract: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: August 9, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Michael G Mauk, Haim H Bau, Daniel Malamud, William Abrams
  • Patent number: 9233368
    Abstract: Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of the amplification products. These devices may be self-contained and do not require any special instruments to operate.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: January 12, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, Changchun Liu, Michael G. Mauk, Robert W. Hart, Xianbo Qiu
  • Patent number: 8911938
    Abstract: Disclosed are preloaded analysis modules comprising reagents disposed within a barrier material capable of liberating the reagents, at a time advantageous to a reaction scheme, when exposed to certain activation conditions or reagents. Also disclosed are related methods for analyzing samples with such modules.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: December 16, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Michael G. Mauk, Haim H. Bau, Amanda W. Dyson, Sudhir Ramprasad, Dafeng Chen, Do Young Byun
  • Publication number: 20140162244
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 12, 2014
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daniel Malamud, Xianbo Ceiu
  • Publication number: 20120315638
    Abstract: Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of the amplification products. These devices may be self-contained and do not require any special instruments to operate.
    Type: Application
    Filed: May 22, 2012
    Publication date: December 13, 2012
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Haim H. Bau, Changchun Li, Michael G. Mauk, Robert W. Hart, Xianbo Qiu
  • Publication number: 20100304986
    Abstract: Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system.
    Type: Application
    Filed: December 14, 2007
    Publication date: December 2, 2010
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Zongyuan Chen, Haim H. Bau, Michael G. Mauk, Xianbao Qiu, Jason Kwa
  • Publication number: 20090226911
    Abstract: Disclosed are preloaded analysis modules comprising reagents disposed within a barrier material capable of liberating the reagents, at a time advantageous to a reaction scheme, when exposed to certain activation conditions or reagents. Also disclosed are related methods for analyzing samples with such modules.
    Type: Application
    Filed: December 10, 2008
    Publication date: September 10, 2009
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Michael G Mauk, Haim H. Bau, Amanda W. Dyson, Sudhir Ramprasad, Dafeng Chen, Do Young Byun
  • Publication number: 20090186357
    Abstract: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.
    Type: Application
    Filed: December 10, 2008
    Publication date: July 23, 2009
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Michael G. Mauk, Haim H. Bau, Daniel Malamud, William Abrams
  • Patent number: 7211521
    Abstract: A structure including at least one layer of germanium formed on a surface of a ceramic substrate is provided. The layer of germanium has a thickness of not larger than 10 microns and includes grains having grain size of at least 0.05 mm. A structure including at least one layer of germanium formed on a surface of a ceramic substrate and having at least one capping layer formed on a surface of the layer of germanium is also provided. In addition, a method of forming a thin film germanium structure is provided including forming at least one layer of germanium on a surface of a ceramic substrate, then forming at least one capping layer on a surface of the layer of germanium, followed by heating and then cooling the layer of germanium.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: May 1, 2007
    Assignee: Heritage Power LLC
    Inventor: Michael G. Mauk
  • Publication number: 20040003837
    Abstract: There are provided photovoltaic-photoelectrochemical devices each comprising a diode and a plurality of separate photocathode elements. Preferably, the devices are positioned in a container in which they are at least partially immersed in electrolyte. Preferably, the devices are positioned in a container which has at least one photocathode reaction product vent and at least one anode reaction product vent. Preferably, the devices are positioned in a container which has an internal partial wall extending from a top portion of the container toward, but not reaching, a bottom portion of the container, the internal partial wall being positioned between the photocathode elements and an anode element which is electrically connected to the p-region of the diode. There are also provided photovoltaic-photoelectrochemical methods using such devices, and methods of making such devices.
    Type: Application
    Filed: April 23, 2003
    Publication date: January 8, 2004
    Applicant: AstroPower, Inc.
    Inventor: Michael G. Mauk
  • Patent number: 6632413
    Abstract: A method of purifying silicon, comprising feeding a sparging gas into a liquid melt [10] containing molten silicon and at least one impurity, in which the sparging gas is used to react with or move one or more impurity contained within the silicon. The products of such reaction or movement may be removed, e.g., by liquid-gas extraction, by liquid-liquid extraction or by liquid-solid extraction.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: October 14, 2003
    Assignee: Astropower, Inc.
    Inventors: Roger F. Clark, Michael G. Mauk, Robert B. Hall, Allen M. Barnett
  • Patent number: 6429463
    Abstract: The invention relates to a device structure and crystal growth process for making the same, whereby single-crystal semiconductor layers are formed over metal or composite layers. The metal layers function as buried reflectors to enhance the performance of LEDs, solar cells, and photodiodes. The structure may also have application to laser diodes. The structures are made by a modification of a well-established metallic solution growth process. The lateral overgrowth process can be enhanced by imposing an electric current at the growth interface (termed liquid-phase electro-epitaxy). However, the use of an electric current is not crucial. The epitaxial lateral overgrowth technique was also applied to silicon growth on metal-masked silicon substrates.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: August 6, 2002
    Assignee: Astropower, Inc.
    Inventor: Michael G. Mauk
  • Publication number: 20020021996
    Abstract: A method of purifying silicon, comprising feeding a sparging gas into a liquid melt [10] containing molten silicon and at least one impurity, in which the sparging gas is used to react with or move one or more impurity contained within the silicon. The products of such reaction or movement may be removed, e.g., by liquid-gas extraction, by liquid-liquid extraction or by liquid-solid extraction.
    Type: Application
    Filed: August 21, 2001
    Publication date: February 21, 2002
    Applicant: AstroPower, Inc.
    Inventors: Roger F. Clark, Michael G. Mauk, Robert B. Hall, Allen M. Barnett