Patents by Inventor Michael G. Pepe

Michael G. Pepe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THE USE OF ENDOTOXIN NEUTRALIZATION AS A BIOMARKER FOR INTESTINAL WALL DAMAGE
    Publication number: 20150152470
    Abstract: Provided herein are methods for detecting endotoxin neutralization in a subject. Also provided are methods for determining the effectiveness of a therapeutic agent for treating intestinal wall damage. Further provided are methods of treating intestinal wall damage are also provided.
    Type: Application
    Filed: June 7, 2013
    Publication date: June 4, 2015
    Inventors: Michael G. Pepe, Milton Keith Champion
  • Enhancing endotoxin detection
    Patent number: 8921063
    Abstract: Provided herein are methods for detecting endotoxin or Gram negative bacteria in a sample. Kits for detecting endotoxin or Gram negative bacteria in a sample are provided.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: December 30, 2014
    Assignee: BioDtech, Inc.
    Inventors: Michael G. Pepe, Milton Keith Champion
  • ENHANCING ENDOTOXIN DETECTION
    Publication number: 20130330759
    Abstract: Provided herein are methods for detecting endotoxin or Gram negative bacteria in a sample. Kits for detecting endotoxin or Gram negative bacteria in a sample are provided.
    Type: Application
    Filed: February 28, 2012
    Publication date: December 12, 2013
    Applicant: BIODTECH, INC.
    Inventors: Michael G. Pepe, Milton Keith Champion
  • Enhancing endotoxin detection
    Patent number: 8349570
    Abstract: Provided herein are methods for detecting gram negative bacteria or lipopolysaccharide in a sample. Kits for detecting gram negative bacteria or lipopolysaccharide in a sample are provided.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: January 8, 2013
    Assignee: BioDtech, Inc.
    Inventors: Michael G. Pepe, Milton Keith Champion
  • Enhancing Endotoxin Detection
    Publication number: 20110020854
    Abstract: Provided herein are methods for detecting gram negative bacteria or lipopolysaccharide in a sample. Kits for detecting gram negative bacteria or lipopolysaccharide in a sample are provided.
    Type: Application
    Filed: September 13, 2010
    Publication date: January 27, 2011
    Applicant: BIODTECH, INC.
    Inventors: Michael G. Pepe, Milton Keith Champion
  • Enhancing endotoxin detection
    Patent number: 7846678
    Abstract: Provided herein are methods for detecting gram negative bacteria or lipopolysaccharide in a sample. Kits for detecting gram negative bacteria or lipopolysaccharide in a sample are provided.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: December 7, 2010
    Assignee: BioDtech, Inc.
    Inventors: Michael G. Pepe, Milton Keith Champion
  • Enhancing Endotoxin Detection
    Publication number: 20100041061
    Abstract: Provided herein are methods for detecting gram negative bacteria or lipopolysaccharide in a sample. Kits for detecting gram negative bacteria or lipopolysaccharide in a sample are provided.
    Type: Application
    Filed: August 18, 2008
    Publication date: February 18, 2010
    Applicant: BioDtech, Inc.
    Inventors: Michael G. Pepe, MILTON KEITH CHAMPION
  • Glucan-specific assay
    Patent number: 5965374
    Abstract: The present invention is directed to monoclonal antibodies which specifically bind to a Limulus .alpha..sub.2 -macroglobulin. Preferred monoclonal antibodies inhibit the enzymatic activation of a Limulus amebocyte lysate to form a gel or to cleave a chromogenic substrate in the presence of an endotoxin but not in the presence of a glucan. The monoclonal antibodies can be used, inter alia, to purify a Limulus .alpha..sub.2 -macroglobulin, and the preferred antibodies can be used in a method for specifically detecting a glucan in a test sample using an amebocyte lysate.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: October 12, 1999
    Assignee: BioWhittaker Technologies, Inc.
    Inventors: Christopher J. Herbstritt, Michael G. Pepe
  • Trypsin Inhibitors
    Patent number: 5714580
    Abstract: Novel compounds having activity against trypsin are disclosed. Specifically, novel peptide aldehyde analogues that have substantial potency and specificity as inhibitors of mammalian pancreatic trypsin are presented. The compounds are useful in the prevention and treatment of the tissue damage or destruction associated with pancreatitis.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: February 3, 1998
    Assignee: Corvas International, Inc.
    Inventors: Terence K. Brunck, Michael G. Pepe, Daniel A. Pearson, Thomas R. Webb
  • Trypsin inhibitors
    Patent number: 5534498
    Abstract: Novel compounds having activity against trypsin are disclosed. Specifically, novel peptide aldehyde analogues that have substantial potency and specificity as inhibitors of mammalian pancreatic trypsin are presented. The compounds are useful in the prevention and treatment of the tissue damage or destruction associated with pancreatitis.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: July 9, 1996
    Assignee: Corvas International, Inc.
    Inventors: Terence K. Brunck, Michael G. Pepe, Daniel A. Pearson, Thomas R. Webb
  • Factor VII/VIIA active site inhibitors
    Patent number: 5023236
    Abstract: The invention includes a class of compounds that inhibit the specific proteolytic activity of the bimolecular complex 1[TF:VII/VIIa] that initiates the blood coagulation systems. Both reversible and irreversible inhibitors are disclosed.The invention encompasses the use of inhibitors of the active site of the factor VII and VIIa component of [TF:VII/VIIa] as diagnostic reagents, as analytical reagents, and as therapeutic drugs.The invention includes the compounds based on the following general formula for both reversible and irreversible selective inhibition of [TF:VII/VIIa].
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: June 11, 1991
    Assignee: Corvas, Inc.
    Inventors: T. Scott Edgington, Michael G. Pepe