Patents by Inventor Michael G. Rosenfeld
Michael G. Rosenfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190040386Abstract: Disclosed herein are methods and compounds for inhibiting gene expression by inhibiting enhancer RNAs (eRNAs). Such methods and compounds are useful for reducing expression of certain genes, many of which are associated with a variety of diseases and disorders.Type: ApplicationFiled: July 11, 2018Publication date: February 7, 2019Applicants: Ionis Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Susan M. Freier, Christopher K. Glass, Michael G. Rosenfeld, Wenbo Li, Michael Tun Yin Lam
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Publication number: 20170226506Abstract: Disclosed herein are methods and compounds for inhibiting gene expression by inhibiting enhancer RNAs (eRNAs). Such methods and compounds are useful for reducing expression of certain genes, many of which are associated with a variety of diseases and disorders.Type: ApplicationFiled: October 3, 2016Publication date: August 10, 2017Applicants: Ionis Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Susan M. Freier, Christopher K. Glass, Michael G. Rosenfeld, Wenbo Li, Michael Tun Yin Lam
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Patent number: 9518261Abstract: Disclosed herein are methods and compounds for inhibiting gene expression by inhibiting enhancer RNAs (eRNAs). Such methods and compounds are useful for reducing expression of certain genes, many of which are associated with a variety of diseases and disorders.Type: GrantFiled: May 22, 2013Date of Patent: December 13, 2016Assignees: Ionis Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Susan M. Freier, Christopher K. Glass, Michael G. Rosenfeld, Wenbo Li, Michael T. Lam
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Publication number: 20150176005Abstract: Disclosed herein are methods and compounds for inhibiting gene expression by inhibiting enhancer RNAs (eRNAs). Such methods and compounds are useful for reducing expression of certain genes, many of which are associated with a variety of diseases and disorders.Type: ApplicationFiled: May 22, 2013Publication date: June 25, 2015Applicants: The Regents of the University of California, Isis Pharmaceuticals, Inc.Inventors: Susan M. Freier, Christopher K. Glass, Michael G. Rosenfeld, Wenbo Li, Michael T. Lam
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Patent number: 8241863Abstract: The present invention relates to a method of screening for a compound that regulate SUMOylation of the nuclear receptor proteins comprising contacting the compound of interest to the nuclear receptor protein, and detecting SUMOylation of the nuclear receptor protein, thereby screening for a compound that regulates SUMOylation.Type: GrantFiled: March 10, 2006Date of Patent: August 14, 2012Assignee: The Regents of the University of CaliforniaInventors: Gabriel Pascual, Christopher K. Glass, Michael G. Rosenfeld
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Patent number: 7981615Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.Type: GrantFiled: November 2, 2009Date of Patent: July 19, 2011Assignee: The Regents of the University of CaliforniaInventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G. Rosenfeld
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Publication number: 20110045462Abstract: The disclosure provides methods and compositions useful for high throughput sequencing of nucleic acid sequences associated with gene expression, nucleic acid-polypeptide interactions, and/or chromosomal interactions.Type: ApplicationFiled: November 14, 2007Publication date: February 24, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Xiang-Dong Fu, Michael G. Rosenfeld
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Publication number: 20100047810Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.Type: ApplicationFiled: November 2, 2009Publication date: February 25, 2010Inventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G. Rosenfeld
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Patent number: 7625874Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.Type: GrantFiled: April 11, 2007Date of Patent: December 1, 2009Assignee: The Regents of the University of CaliforniaInventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G Rosenfeld
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Publication number: 20080182778Abstract: The present invention relates to a method of screening for a compound that regulate SUMOylation of the nuclear receptor proteins comprising contacting the compound of interest to the nuclear receptor protein, and detecting SUMOylation of the nuclear receptor protein, thereby screening for a compound that regulates SUMOylation.Type: ApplicationFiled: March 10, 2006Publication date: July 31, 2008Inventors: Gabriel Pascual, Christopher K. Glass, Michael G. Rosenfeld
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Publication number: 20070238692Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.Type: ApplicationFiled: April 11, 2007Publication date: October 11, 2007Applicant: The Regents of the University of CaliforniaInventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G. Rosenfeld
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Patent number: 7211402Abstract: The present invention provides a substantially purified nucleic acid molecule encoding a p/CIP polypeptide, which regulates the activity of CBP/p300-dependent transcription factors. The invention also provides a substantially purified p-CIP polypeptide and active fragments thereof. In addition, the invention provides methods of identifying an effective agent that alters the association of a p/CIP polypeptide with a second protein. Further provided herein are methods of selectively inhibiting signal transduction pathways using an active fragment of a p/CIP polypeptide or a nucleic acid molecule encoding such an acive fragment.Type: GrantFiled: October 21, 2004Date of Patent: May 1, 2007Assignee: The Regents of the University of CaliforniaInventors: Michael G. Rosenfeld, Christopher K. Glass, David W. Rose, Joseph Torchia
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Patent number: 6812336Abstract: The present invention provides a substantially purified nucleic acid molecule encoding p/CIP, which regulates the activity of CBP/p300 dependent transcription factors. The invention also provides substantially purified p/CIP and peptide portions of p/CIP. The invention also provides methods of selectively inhibiting signal transduction pathways using a peptide portion of p/CIP or a nucleic acid molecule encoding such a peptide portion.Type: GrantFiled: May 5, 2000Date of Patent: November 2, 2004Assignee: The Regents of the University of CaliforniaInventors: Michael G. Rosenfeld, Christopher K. Glass, David W. Rose, Joseph Torchia
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Patent number: 5612220Abstract: Disclosed is a POU transcription factor, Sprm-1 and analogs thereof, DNA molecules encoding the Sprm-1 proteins, and chimeric constructs, vectors and host cells containing the DNA molecules. Also disclosed are methods to identify putative male contraceptive agents. One involves the steps of isolating a DNA regulatory region responsive to Sprm-1, stably transforming a heterologous cell line with a first chimeric DNA construct containing a constitutive promoter capable of functioning in the cell line operably linked to a Sprm-1 DNA and a second chimeric DNA construct containing the DNA regulatory region operably linked to a reporter gene. The thus-transformed cell line is cultural in media containing the compound so that the thus-cultured cell line can be assayed to determine the Sprm-1 inhibitory activity of the compound.Type: GrantFiled: December 1, 1994Date of Patent: March 18, 1997Assignee: The Population Council, Center for Biomedical ResearchInventors: Bogi Andersen, Richard V. Pearse, Peter N. Schlegel, Michael G. Rosenfeld, C. Wayne Bardin
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Patent number: 5561224Abstract: A gene encoding for alternative forms of a POU domain transcription factor is disclosed. The first polypeptide form of the transcription factor includes a transferable region which inhibits DNA binding by itself and other transcription factors. The second polypeptide form serves to activate expression of a gene typical for terminal differentiation of skin. Fusion proteins wherein the inhibitory region of the first form of the gene is coupled to, and inhibits the function of, other transcription factors are also disclosed.Type: GrantFiled: July 20, 1995Date of Patent: October 1, 1996Assignee: The Regents of the University of CaliforniaInventors: Michael G. Rosenfeld, Bogi Anderson
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Patent number: 5484732Abstract: A gene encoding for alternative forms of a POU domain transcription factor is disclosed. The first polypeptide form of the transcription factor includes a transferable region which inhibits DNA binding by itself and other transcription factors. The second polypeptide form serves to activate expression of a gene typical for terminal differentiation of skin. Fusion proteins wherein the inhibitory region of the first form of the gene is coupled to, and inhibits the function of, other transcription factors are also disclosed.Type: GrantFiled: March 22, 1993Date of Patent: January 16, 1996Assignee: The Regents of the University of CaliforniaInventors: Michael G. Rosenfeld, Bogi Anderson
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Patent number: 4737578Abstract: Proteins with inhibin activity having a weight of about 32,000 daltons. The molecule is composed of two chains having molecular weights of about 18,000 and about 14,000 daltons, respectively, which are bound together by disulfide bonding. The 18K chain is obtained from the human inhibin gene and has the formula: H-Ser-Thr-Pro-Leu-Met-Ser-Trp-Pro-Trp-Ser-Pro-Ser-Ala-Leu-Arg-Leu-Leu-Gln- Arg-Pro-Pro-Glu-Glu-Pro-Ala-Ala-His-Ala-Asn-Cys-His-Arg-Val-Ala-Leu-Asn-Ile -Ser-Phe-Gln-Glu-Leu-Gly-Trp-Glu-Arg-Trp-Ile-Val-Tyr-Pro-Pro-Ser-Phe-R.sub. 65 -Phe-His-Tyr-Cys-His-Gly-Gly-Cys-Gly-Leu-His-Ile-Pro-Pro-Asn-Leu-Ser-Leu-P ro-Val-Pro-Gly-Ala-Pro-Pro-Thr-Pro-Ala-Gln-Pro-Tyr-Ser-Leu-Leu-Pro-Gly-Ala- Gln-Pro-Cys-Cys-Ala-Ala-Leu-Pro-Gly-Thr-Met-Arg-Pro-Leu-His-Val-Arg-Thr-Thr -Ser-Asp-Gly-Gly-Tyr-Ser-P e-Lys-Tyr-Glu-Thr-Val-Pro-Asn-Leu-Leu-Thr-Gln-His-Cys-Ala-Cys-Ile-OH, wherein R.sub.65 is Ile or Arg. The 18K chain is connected by disulfide bonding to the 14K chain.Type: GrantFiled: April 7, 1986Date of Patent: April 12, 1988Assignee: The Salk Institute for Biological StudiesInventors: Ronald M. Evans, Michael G. Rosenfeld, Gail Cerelli, Kelly E. Mayo, Joachim Spiess, Jean E. F. Rivier, Wylie W. Vale, Jr.
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Patent number: 4736023Abstract: Human CGRP (calcitonin-gene-related peptide) has the formula: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg- Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe -NH.sub.2. Human CGRP or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception. By using human CGRP to generate production of antibodies, it should be possible to diagnose human medullary thyroid carcinoma via immunoassay techniques.Type: GrantFiled: March 4, 1985Date of Patent: April 5, 1988Assignee: The Salk Institute for Biological StudiesInventors: Ronald M. Evans, Michael G. Rosenfeld
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Patent number: 4549986Abstract: Human CGRP (calcitonin-gene-related peptide) has the formula: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg- Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe -NH.sub.2. Human CGRP or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception. By using human CGRP to generate production of antibodies, it should be possible to diagnose human medullary thyroid carcinoma via immunoassay techniques.Type: GrantFiled: December 23, 1983Date of Patent: October 29, 1985Assignee: The Salk Institute for Biological StudiesInventors: Ronald M. Evans, Michael G. Rosenfeld
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Patent number: 4530838Abstract: CGRP (calcitonin-gene-related peptide) has the formula: ##STR1## A related peptide has the residue Lys instead of Glu in the 35-position. CGRP or this homolog or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception.Type: GrantFiled: July 8, 1983Date of Patent: July 23, 1985Assignee: The Salk Institute for Biological StudiesInventors: Ronald M. Evans, Larry Swanson, Wylie W. Vale, Jr., Michael G. Rosenfeld, Susan G. Amara, Marvin R. Brown, Jean E. F. Rivier