Abstract: Markers useful for determining multiple sclerosis activity in a human subject are provided, along with kits for measuring quantitative expression values of the markers. Also provided are computer systems and software embodiments of predictive models for scoring and determining multiple sclerosis activity in human subjects based on the quantitative expression values of the markers.

Abstract: Markers useful for determining multiple sclerosis activity in a human subject are provided, along with kits for measuring quantitative expression values of the markers. Also provided are computer systems and software embodiments of predictive models for scoring and determining multiple sclerosis activity in human subjects based on the quantitative expression values of the markers.

Abstract: A computer system for analyzing nucleic acid sequences is provided. The computer system is used to calculate probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Additionally, information from multiple experiments is utilized to improve the accuracy of calling unknown bases.

Abstract: The invention provides mammalian cDNAs which encode Xin-related proteins. It also provides for the use of the cDNAs, fragments, and complements thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cardiac and skeletal muscle disorders, particularly hypertrophic cardiomyopathy, and for monitoring cardiac and skeletal muscle morphogenesis and development. The invention additionally provides expression vectors and host cells for the production of the proteins.

Abstract: The invention provides polynucleotides that encode SPARC-related proteins. It also provides for the use of the polynucleotide, protein, and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides methods for using the polynucleotides, proteins and antibodies.

Abstract: A computer system for analyzing nucleic acid sequences is provided. The computer system is used to calculate probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Additionally, information from multiple experiments is utilized to improve the accuracy of calling unknown bases.

Abstract: A method and system for generating and searching a tree-structured index of window vectors that represent database sequences comprise a window vector generation module, a tree-structured index generation module, a query sequence partitioning module, and a retrieval component. The window vector generation module partitions a database sequence into a plurality of overlapping windows. Each window has a fixed length W comprising a fixed number of nucleotides, and the offset among windows is determined by a parameter &Dgr;. The window vector generation module then maps each database sequence window into a window vector. The database sequence window vector indicates the frequency of appearance of each k-tuple in the corresponding database sequence window. The tree-structured index generation module then generates a tree-structured index using the database sequence window vectors.

Abstract: The invention provides polynucleotides that are specifically expressed in kidney function or kidney disorders. The invention also provides compositions, probes, expression vectors, host cells, proteins encoded by the polynucleotides and agonist, antagonists and antibodies which specifically bind the proteins. The invention also provides methods for assessing kidney function and for the diagnosis, prognosis, treatment and evaluation of therapies for kidney disorders.

Abstract: The invention provides compositions and novel polynucleotides and proteins that co-express with known marker genes for inflammatory disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of inflammatory disorders.

Abstract: The invention provides compositions and novel polynucleotides and their encoded proteins that serve as surrogate markers in that they co-express with genes known to be involved associated with disorders associated with cardiac muscle function. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of disorders associated with cardiac muscle function.

Abstract: The invention provides novel cDNAs that coexpress with known placental steroid synthesis genes. The invention also provides expression vectors, host cells, proteins encoded by the cDNAs and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of disorders associated with steroid-responsive tissues and with pregnancy.

Abstract: The invention provides a mammalian cDNA which encodes a mammalian GRIIP. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of disorders associated with inflammation and immune response, particularly cancers of the immune system. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides a mammalian cDNA which encodes a mammalian AQP8V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of pancreatic disorders, particularly type I diabetes. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides compositions and novel polynucleotides and proteins that co-express with known marker genes for inflammatory disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of inflammatory disorders.

Abstract: The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in cardiovascular diseases. The combination and compositions can be used entirely or in part to diagnose, to stage, to treat, or to monitor the progression or treatment of disorders associated with atherosclerosis.

Abstract: The invention provides cDNAs that are significantly co-expressed with known lung surfactant and surfactant synthesis genes. The invention also provides compositions, expression vectors, host cells, proteins encoded by the cDNAs and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, treatment and evaluation of therapies for lung disorders.

Abstract: The invention provides a mammalian cDNA which encodes a mammalian Ankrd2V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of muscle disorders such as muscle hypertrophy and particularly clear cell sarcoma. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides polynucleotides that encode SPARC-related proteins. It also provides for the use of the polynucleotide, protein, and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides methods for using the polynucleotides, proteins and antibodies.

Abstract: The invention provides polynucleotides that are differentially expressed in breast cancer. The invention also provides a combination of polynucleotides, proteins encoded by the polynucleotides, and antibodies which specifically bind a protein, compositions, probes, expression vectors, and host cells. The invention also provides methods for the diagnosis, prognosis, treatment and evaluation of therapies for breast cancer.

Abstract: The invention provides a Ras association domain containing protein, its encoding mammalian cDNA, and an antibody that specifically binds the protein. It also provides for the use of the cDNAs, complements, and variants thereof and of the protein, portions thereof and antibodies thereto to diagnose, stage, treat or monitor the progression or treatment of cell proliferative and inflammatory disorders.