Patents by Inventor Michael G. Youngquist
Michael G. Youngquist has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11703428Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: GrantFiled: November 1, 2021Date of Patent: July 18, 2023Assignee: Life Technologies CorporationInventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
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Publication number: 20220113229Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: ApplicationFiled: November 1, 2021Publication date: April 14, 2022Inventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
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Patent number: 11175203Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: GrantFiled: February 13, 2020Date of Patent: November 16, 2021Assignee: Life Technologies CorporationInventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
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Publication number: 20200284702Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: ApplicationFiled: February 13, 2020Publication date: September 10, 2020Inventors: Thomas M. BAER, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
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Patent number: 10605706Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: GrantFiled: December 3, 2018Date of Patent: March 31, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
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Publication number: 20190120734Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: ApplicationFiled: December 3, 2018Publication date: April 25, 2019Inventors: Thomas M. BAER, Michael G. YOUNGQUIST, Brian W. DONOVAN, Alan E. WESSEL, Norbert H. LECLERC, Michael A. SMITH, Craig S. BARKER, George M. DAWSON
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Patent number: 10156501Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: GrantFiled: February 16, 2017Date of Patent: December 18, 2018Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
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Publication number: 20170284907Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: ApplicationFiled: February 16, 2017Publication date: October 5, 2017Inventors: Thomas M. Baer, Michael G. YOUNGQUIST, Brian W. DONOVAN, Alan E. WESSEL, Norbert H. LECLERC, Michael A. SMITH, Craig S. BARKER, George M. DAWSON
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Publication number: 20140335560Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: ApplicationFiled: May 12, 2014Publication date: November 13, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Thomas M. BAER, Michael G. YOUNGQUIST, Brian W. DONOVAN, Alan E. WESSEL, Norbert H. LECLERC, Michael A. SMITH, Craig S. BARKER, George M. DAWSON
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Patent number: 8722357Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.Type: GrantFiled: September 26, 2005Date of Patent: May 13, 2014Assignee: Life Technologies CorporationInventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, George M. Dawson, Craig S. Barker
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Patent number: 7256393Abstract: Signal amplifiers having a non-linear transfer function. A high speed (high bandwidth) circuit with a non-linear transfer function over a limited range of input signal is provided. By appropriate choice of components, the non-linear transfer function can be used to accurately approximate any monotonic function such as a square root transfer function. In another aspect, a piecewise non-linear circuit arrangement using a set of non-linear sub-circuits is provided to accurately generate a desired non-linear transfer function over an extended dynamic range of input signal. In one implementation of such a circuit, each of the sub-circuits approximates the desired non-linear function over a portion of the input range.Type: GrantFiled: June 30, 2005Date of Patent: August 14, 2007Assignee: Bio-Rad Laboratories, Inc.Inventors: Craig A. Keller, Steve Waltman, Steve Miller, Michael G. Youngquist
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Patent number: 7129483Abstract: Laser desorption/ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.Type: GrantFiled: June 17, 2005Date of Patent: October 31, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: Michael G. Youngquist, Craig A. Keller
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Patent number: 6866461Abstract: The present invention comprises a loading device for automating transfer of a plurality of probes between a cassette within which the plurality of probes are initially constrained and an analytical instrument, e.g., mass spectrometer. The loading device may be configured to accept a single or a plurality of cassettes each removably constraining a plurality of probes to be analyzed. The loading device may permit each of the plurality of cassettes to be independently interchanged with a separate cassette removably constraining a separate plurality of probes during mass spectrometric analysis, or for additional cassettes to be loaded into the device during analysis. In a useful embodiment, the loading device comprises a cassette transport assembly and a probe insertion assembly. The cassette transport assembly linearly translates one or more cassettes to align the cassette(s) with respect to the mass spectrometer so that a probe may be translated therebetween by the probe insertion assembly.Type: GrantFiled: February 25, 2003Date of Patent: March 15, 2005Assignee: Ciphergen Biosystems, Inc.Inventors: Scott M. DeWinter, John B. Rusconi, Steven M. Clark, Michael P. Lucas, Michael G. Youngquist
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Patent number: 6765199Abstract: A method for processing time-dependent signal data is disclosed. The time-dependent signal data are received in a memory, wherein the time-dependent signal data represent a time-dependent signal, and wherein the time-dependent signal data include representations of time-of-flight values of ions, or values derived from time-of-flight values of ions. The time-dependent signal data are scaled with a time-dependent scaling function.Type: GrantFiled: July 10, 2002Date of Patent: July 20, 2004Assignee: Ciphergen Biosystems, Inc.Inventors: Michael G. Youngquist, Edward Gavin, William E. Rich
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Publication number: 20030180128Abstract: The present invention comprises a loading device for automating transfer of a plurality of probes between a cassette within which the plurality of probes are initially constrained and an analytical instrument, e.g., mass spectrometer. The loading device may be configured to accept a single or a plurality of cassettes each removably constraining a plurality of probes to be analyzed. The loading device may permit each of the plurality of cassettes to be independently interchanged with a separate cassette removably constraining a separate plurality of probes during mass spectrometric analysis, or for additional cassettes to be loaded into the device during analysis. In a useful embodiment, the loading device comprises a cassette transport assembly and a probe insertion assembly. The cassette transport assembly linearly translates one or more cassettes to align the cassette(s) with respect to the mass spectrometer so that a probe may be translated therebetween by the probe insertion assembly.Type: ApplicationFiled: February 25, 2003Publication date: September 25, 2003Applicant: Ciphergen Biosystems, Inc.Inventors: Scott M. DeWinter, John B. Rusconi, Steven M. Clark, Michael P. Lucas, Michael G. Youngquist
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Publication number: 20030175170Abstract: The present invention comprises a system to facilitate sample preparation, common transport, and storage of a plurality of laser desorption ionization probes to be interrogated in a mass spectrometer. The system includes a plurality of probes, a cassette that accepts the plurality of probes, a well-plate that engages the cassette and permits delivery of samples to the probes without fluid communication between samples, and a clamp to secure the well-plate to the cassette. The cassette is configured to constrain the plurality of probes so that the probes suspend from ribs disposed within the cassette. This permits the top and bottom surfaces of the probes to be substantially exposed and facilitates insertion and removal of the probes from the cassette without user contact of active areas on the probes.Type: ApplicationFiled: February 25, 2003Publication date: September 18, 2003Applicant: Ciphergen Biosystems, Inc.Inventors: Michael G. Youngquist, John B. Rusconi
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Patent number: 6580071Abstract: A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.Type: GrantFiled: July 11, 2002Date of Patent: June 17, 2003Assignee: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Edward J. Gavin, Michael G. Youngquist
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Publication number: 20030062473Abstract: A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.Type: ApplicationFiled: July 11, 2002Publication date: April 3, 2003Applicant: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Edward J. Gavin, Michael G. Youngquist
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Publication number: 20030057370Abstract: A method for processing time-dependent signal data is disclosed. The time-dependent signal data are received in a memory, wherein the time-dependent signal data represent a time-dependent signal, and wherein the time-dependent signal data include representations of time-of-flight values of ions, or values derived from time-of-flight values of ions. The time-dependent signal data are scaled with a time-dependent scaling function.Type: ApplicationFiled: July 10, 2002Publication date: March 27, 2003Applicant: CIPHERGEN BIOSYSTEMS, INC.Inventors: Michael G. Youngquist, Edward Gavin, William E. Rich